Regeneron Pharmaceuticals (REGN) had the highest return between 2011 and 2013 by a US stock in the S&P 500 (GSPC), returning 742%.

ASSET	YEARS	% RETURN
Regeneron Pharmaceuticals (REGN)	2011-2013	741.97%
Tesla (TSLA)	2011-2013	460.44%
Generac (GNRC)	2011-2013	426.06%
Tyler Technologies (TYL)	2011-2013	387.73%
Domino's Pizza Inc Common Stock (DPZ)	2011-2013	373.73%
Seagate Technology (STX)	2011-2013	314.28%
Biogen (BIIB)	2011-2013	313.08%
Gilead Sciences (GILD)	2011-2013	309.93%
Contura Energy (CTRA)	2011-2013	307.62%
Corpay (CPAY)	2011-2013	274.94%
Mastercard (MA)	2011-2013	272%
Targa Resources (TRGP)	2011-2013	258.83%
Builders FirstSource (BLDR)	2011-2013	256.5%
Charter Communications (CHTR)	2011-2013	249.95%
MarketAxess (MKTX)	2011-2013	244.69%
Paramount Global Class B (PARA)	2011-2013	243.16%
United Rentals (URI)	2011-2013	236.86%
Axon Enterprise (AXON)	2011-2013	234.32%
Visa Inc Class A (V)	2011-2013	223.84%
Tractor Supply (TSCO)	2011-2013	223.62%
CoStar (CSGP)	2011-2013	217.8%
Constellation Brands Inc Class A (STZ)	2011-2013	217.31%
LyondellBasell Industries (LYB)	2011-2013	207.48%
Moodys (MCO)	2011-2013	206.5%
Expedia (EXPE)	2011-2013	206.13%