Netflix (NFLX) had the highest return between 2008 and 2017 by a US stock in the S&P 500 (GSPC), returning 4,959.2%.

ASSET	YEARS	% RETURN
Netflix (NFLX)	2008-2017	4,959.17%
MarketAxess (MKTX)	2008-2017	1,715.46%
Broadcom (AVGO)	2008-2017	1,649.23%
Tesla (TSLA)	2008-2017	1,538.64%
Domino's Pizza Inc Common Stock (DPZ)	2008-2017	1,536.71%
Regeneron Pharmaceuticals (REGN)	2008-2017	1,465.19%
Booking (BKNG)	2008-2017	1,388.43%
Ross Stores (ROST)	2008-2017	1,299.51%
Tyler Technologies (TYL)	2008-2017	1,278.89%
Align Technology (ALGN)	2008-2017	1,232.07%
Ulta Beauty (ULTA)	2008-2017	1,230.37%
Old Dominion Freight Line (ODFL)	2008-2017	1,209.02%
Transdigm (TDG)	2008-2017	1,142.84%
Dollar Tree (DLTR)	2008-2017	1,142.01%
Smith AO (AOS)	2008-2017	1,127.15%
Amazon (AMZN)	2008-2017	1,126.5%
Skyworks Solutions (SWKS)	2008-2017	1,071.85%
Texas Pacific Land Trust (TPL)	2008-2017	945.21%
Constellation Brands Inc Class A (STZ)	2008-2017	896.22%
Edwards Lifesciences (EW)	2008-2017	886.09%
Charter Communications (CHTR)	2008-2017	859.89%
Incyte (INCY)	2008-2017	843.33%
United Rentals (URI)	2008-2017	837.86%
Home Depot (HD)	2008-2017	807.85%
Tractor Supply (TSCO)	2008-2017	805.67%