Regeneron Pharmaceuticals (REGN) had the highest return between 2010 and 2013 by a US stock in the S&P 500 (GSPC), returning 1,035.5%.

ASSET	YEARS	% RETURN
Regeneron Pharmaceuticals (REGN)	2010-2013	1,035.48%
Domino's Pizza Inc Common Stock (DPZ)	2010-2013	794.16%
Tesla (TSLA)	2010-2013	691.71%
United Rentals (URI)	2010-2013	685.79%
Netflix (NFLX)	2010-2013	563.13%
Generac (GNRC)	2010-2013	561.22%
Tractor Supply (TSCO)	2010-2013	501.9%
Chipotle Mexican Grill (CMG)	2010-2013	494.62%
Las Vegas Sands (LVS)	2010-2013	462.11%
Incyte (INCY)	2010-2013	449.13%
Booking (BKNG)	2010-2013	422.85%
MarketAxess (MKTX)	2010-2013	422.74%
Biogen (BIIB)	2010-2013	418.01%
Tyler Technologies (TYL)	2010-2013	409.38%
Ulta Beauty (ULTA)	2010-2013	407.54%
LyondellBasell Industries (LYB)	2010-2013	380.22%
Paramount Global Class B (PARA)	2010-2013	371.6%
Corpay (CPAY)	2010-2013	368.68%
Constellation Brands Inc Class A (STZ)	2010-2013	339.33%
CoStar (CSGP)	2010-2013	335.54%
DexCom (DXCM)	2010-2013	331.3%
Transdigm (TDG)	2010-2013	324.33%
Wynn Resorts (WYNN)	2010-2013	313.03%
Targa Resources (TRGP)	2010-2013	300.82%
Caesars Entertainment (CZR)	2010-2013	296.92%