Enphase Energy (ENPH) had the highest return between 2019 and 2022 by a US stock in the S&P 500 (GSPC), returning 5,622.7%.

ASSET	YEARS	% RETURN
Enphase Energy (ENPH)	2019-2022	5,622.68%
Moderna (MRNA)	2019-2022	1,103.08%
Builders FirstSource (BLDR)	2019-2022	508.63%
Tesla (TSLA)	2019-2022	503.63%
Super Micro Computer (SMCI)	2019-2022	495.36%
Quanta Services (PWR)	2019-2022	387.42%
Texas Pacific Land Trust (TPL)	2019-2022	374.86%
KLA-Tencor (KLAC)	2019-2022	360.51%
NVIDIA (NVDA)	2019-2022	350.77%
Trade Desk (TTD)	2019-2022	300.77%
Freeport-McMoran Copper & Gold (FCX)	2019-2022	297.35%
Synopsys (SNPS)	2019-2022	287.63%
DexCom (DXCM)	2019-2022	287.11%
ON Semiconductor (ON)	2019-2022	286.43%
Axon Enterprise (AXON)	2019-2022	285.97%
Hess (HES)	2019-2022	285.32%
Insulet (PODD)	2019-2022	278.64%
Cadence Design Systems (CDNS)	2019-2022	276.65%
Steel Dynamics (STLD)	2019-2022	271.39%
First Solar (FSLR)	2019-2022	259.81%
Advanced Micro Devices (AMD)	2019-2022	259.63%
Fortinet (FTNT)	2019-2022	256.45%
Carrier Global (CARR)	2019-2022	256.43%
Old Dominion Freight Line (ODFL)	2019-2022	256.41%
McKesson (MCK)	2019-2022	254.54%