Advanced Micro Devices (AMD) had the highest return between 2016 and 2021 by a US stock in the S&P 500 (GSPC), returning 5,094.9%.

ASSET	YEARS	% RETURN
Advanced Micro Devices (AMD)	2016-2021	5,094.95%
NVIDIA (NVDA)	2016-2021	3,627.25%
Trade Desk (TTD)	2016-2021	3,087.48%
Tesla (TSLA)	2016-2021	2,190.18%
Block (XYZ)	2016-2021	1,166.75%
Generac (GNRC)	2016-2021	1,101.91%
Fortinet (FTNT)	2016-2021	1,076.82%
Moderna (MRNA)	2016-2021	1,054.45%
Paycom Soft (PAYC)	2016-2021	1,018.81%
Texas Pacific Land Trust (TPL)	2016-2021	963.75%
Match (MTCH)	2016-2021	934.65%
Lam Research (LRCX)	2016-2021	917.56%
Align Technology (ALGN)	2016-2021	911.2%
Old Dominion Freight Line (ODFL)	2016-2021	841.85%
Cadence Design Systems (CDNS)	2016-2021	831.75%
Applied Materials (AMAT)	2016-2021	831.13%
Axon Enterprise (AXON)	2016-2021	823.53%
MSCI (MSCI)	2016-2021	818.95%
IDEXX Laboratories (IDXX)	2016-2021	810.1%
Zebra Technologies (ZBRA)	2016-2021	779.43%
EPAM Systems (EPAM)	2016-2021	757.32%
Teradyne (TER)	2016-2021	735.3%
Monolithic Power Systems (MPWR)	2016-2021	734%
Synopsys (SNPS)	2016-2021	716.89%
West Pharmaceutical Services (WST)	2016-2021	714.52%