Thomson Reuters Corporation Common Shares (TRI) had the highest return between 2000 and 2002 by a large-cap US stock, returning 828,056.3%.

ASSET	YEARS	% RETURN
Thomson Reuters Corporation Common Shares (TRI)	2000-2002	828,056.25%
Ovintiv (OVV)	2000-2002	4,469.45%
Clean Harbors (CLH)	2000-2002	1,176.67%
Royal Gold (RGLD)	2000-2002	614.63%
NVR (NVR)	2000-2002	583.77%
Tractor Supply (TSCO)	2000-2002	368.13%
Hudbay Minerals (HBM)	2000-2002	348.91%
Altria (MO)	2000-2002	273.54%
Quest Diagnostics (DGX)	2000-2002	269.33%
DaVita HealthCare Partners (DVA)	2000-2002	265.48%
HF Sinclair (DINO)	2000-2002	258.16%
CoreSite Realty (COR)	2000-2002	251.05%
Brown & Brown (BRO)	2000-2002	246.56%
Gold Fields Ltd ADR (GFI)	2000-2002	236.27%
East West Bancorp (EWBC)	2000-2002	235.31%
Tapestry (TPR)	2000-2002	229.2%
Lennar (LEN)	2000-2002	221.68%
CACI International (CACI)	2000-2002	215.05%
UnitedHealth (UNH)	2000-2002	214.82%
Wintrust Financial (WTFC)	2000-2002	213.27%
Hecla Mining (HL)	2000-2002	211.37%
Renaissancere (RNR)	2000-2002	210.25%
Harmony Gold Mining (HMY)	2000-2002	193.98%
EMCOR (EME)	2000-2002	190.47%
Ryanair Holdings PLC ADR (RYAAY)	2000-2002	188.75%

Large-cap stocks are treated as having a market cap of $10B+.