Sociedad Quimica y Minera de Chile SA ADR B (SQM) had the highest return between 2008 and 2009 by a large-cap US stock, returning 111%.

ASSET	YEARS	% RETURN
Sociedad Quimica y Minera de Chile SA ADR B (SQM)	2008-2009	111.04%
Netflix (NFLX)	2008-2009	107.42%
Alamos Gold (AGI)	2008-2009	100.51%
NetEase (NTES)	2008-2009	98.01%
Edwards Lifesciences (EW)	2008-2009	89.96%
F5 Networks (FFIV)	2008-2009	89.04%
Booking (BKNG)	2008-2009	87.08%
Dollar Tree (DLTR)	2008-2009	86.34%
Vertex Pharmaceuticals (VRTX)	2008-2009	84.3%
Franco-Nevada (FNV)	2008-2009	79.24%
Ross Stores (ROST)	2008-2009	71.59%
Centrais Electricas Brasileiras (EBR)	2008-2009	71.57%
Stifel Financial (SF)	2008-2009	69.94%
Skyworks Solutions (SWKS)	2008-2009	67.53%
Waste Connections (WCN)	2008-2009	66.19%
Celestica (CLS)	2008-2009	61.64%
Celsius (CELH)	2008-2009	58.14%
Synnex (SNX)	2008-2009	57.23%
Tyler Technologies (TYL)	2008-2009	55.06%
Watsco (WSO.B)	2008-2009	53.38%
Royal Gold (RGLD)	2008-2009	53.23%
Check Point Software Technologies (CHKP)	2008-2009	52.27%
Evercore Partners (EVR)	2008-2009	51.67%
Wipro Limited ADR (WIT)	2008-2009	50.81%
Centrais Elétricas Brasileiras SA - Eletrobrás (EBR.B)	2008-2009	49.5%

Large-cap stocks are treated as having a market cap of $10B+.