GeoVax Labs (GOVX) had the highest return between 2008 and 2010 by a US stock, returning 5,263,157,794.2%.

ASSET	YEARS	% RETURN
GeoVax Labs (GOVX)	2008-2010	5,263,157,794.21%
Future Fintech (FTFT)	2008-2010	47,692,207.69%
Ridgetech (RDGT)	2008-2010	6,872,646.45%
Metalla Royalty & Streaming (MTA)	2008-2010	228,557.14%
Pioneer Power Solutions (PPSI)	2008-2010	29,429.23%
Arena (AREN)	2008-2010	15,546.55%
Versus Systems Inc. (VS)	2008-2010	15,336.8%
BTCS (BTCS)	2008-2010	5,920.01%
LifeMD (LFMD)	2008-2010	1,983.33%
Lineage Cell Therapeutics (LCTX)	2008-2010	1,931.89%
Oxley Bridge Acquisition Limited Class A Ordinary Shares (OBA)	2008-2010	1,648.43%
Mitek Systems (MITK)	2008-2010	1,492.11%
Radcom (RDCM)	2008-2010	1,427.88%
Brand House Collective (TBHC)	2008-2010	1,376.83%
Ammo (POWW)	2008-2010	1,100%
ClearOne (CLRO)	2008-2010	937.09%
Amneal Pharmaceuticals, Inc Class A Common Stock (AMRX)	2008-2010	704.4%
NextTrip (NTRP)	2008-2010	650%
Mesoblast (MESO)	2008-2010	619.47%
Edesa Biotech (EDSA)	2008-2010	615%
VirTra (VTSI)	2008-2010	612%
FiEE (FIEE)	2008-2010	600%
Netflix (NFLX)	2008-2010	561.57%
Gold Resource (GORO)	2008-2010	552.78%
iBio, Inc Common Stock (IBIO)	2008-2010	532%