Hirequest (HQI) had the highest return between 2001 and 2022 by a US stock, returning 7,498,550%.

ASSET	YEARS	% RETURN
Hirequest (HQI)	2001-2022	7,498,550%
BioNexus Gene Lab Corp Common stock (BGLC)	2001-2022	2,780,387.8%
LMF Acquisition Opportunities (ICU)	2001-2022	2,614,695.92%
KULR Technology (KULR)	2001-2022	2,399,900%
Next Technology (NXTT)	2001-2022	1,162,346.87%
Cemtrex (CETX)	2001-2022	1,031,471.16%
Sequans Communications (SQNS)	2001-2022	999,900%
MDxHealth SA ADR (MDXH)	2001-2022	734,344.44%
Connexa Sports Technologies (YYAI)	2001-2022	467,900%
Heart Test Laboratories Inc Common Stock (HSCS)	2001-2022	246,958.82%
Zivo Bioscience (ZIVO)	2001-2022	220,488.24%
AquaBounty Technologies (AQB)	2001-2022	212,122.22%
Immatics (IMTX)	2001-2022	174,100%
GeoVax Labs (GOVX)	2001-2022	147,556.25%
Iqstel (IQST)	2001-2022	146,895.96%
Eastside Distilling (BLNE)	2001-2022	137,437.54%
QXO (QXO)	2001-2022	133,766.43%
Monster Beverage (MNST)	2001-2022	127,771.54%
Integra Resources (ITRG)	2001-2022	126,500%
Aurora Cannabis (ACB)	2001-2022	122,966.67%
MEDIFAST (MED)	2001-2022	102,357.52%
Perspective Therapeutics (CATX)	2001-2022	83,233.33%
Ring Energy (REI)	2001-2022	81,900%
Blackboxstocks (BLBX)	2001-2022	70,488.24%
Franklin Wireless (FKWL)	2001-2022	70,147.62%