InspireMD (NSPR) had the lowest return between 2016 and 2020 by a US stock, returning -100%.

ASSET	YEARS	% RETURN
InspireMD (NSPR)	2016-2020	-100%
MetroCity Bankshares (MCBS)	2016-2020	-100%
Golden Matrix (GMGI)	2016-2020	-99.99%
Cenntro Electric (CENN)	2016-2020	-99.99%
PCB Bancorp (PCB)	2016-2020	-99.99%
Aytu BioScience (AYTU)	2016-2020	-99.99%
Performance Shipping (PSHG)	2016-2020	-99.99%
Sellas Life Sciences (SLS)	2016-2020	-99.99%
TOP Ships (TOPS)	2016-2020	-99.97%
Creative Medical Technology (CELZ)	2016-2020	-99.96%
Seanergy Maritime (SHIP)	2016-2020	-99.93%
BTCS (BTCS)	2016-2020	-99.9%
Viewbix Inc Common Stock (VBIX)	2016-2020	-99.9%
Axe Compute (AGPU)	2016-2020	-99.9%
Nextplat (NXPL)	2016-2020	-99.89%
GeoVax Labs (GOVX)	2016-2020	-99.87%
Phio Pharmaceuticals (PHIO)	2016-2020	-99.87%
Plus Therapeutics (PSTV)	2016-2020	-99.86%
BioRestorative Therapies (BRTX)	2016-2020	-99.84%
Atlas Lithium Corporation Common Stock (ATLX)	2016-2020	-99.8%
Achieve Life Sciences (ACHV)	2016-2020	-99.68%
Traws Pharma (TRAW)	2016-2020	-99.67%
ReWalk Robotics (LFWD)	2016-2020	-99.62%
Palisade Bio (PALI)	2016-2020	-99.6%
Precipio (PRPO)	2016-2020	-99.55%