BioNexus Gene Lab Corp Common stock (BGLC) had the highest return between 2021 and 2022 by a US stock, returning 4,956,421.7%.

ASSET	YEARS	% RETURN
BioNexus Gene Lab Corp Common stock (BGLC)	2021-2022	4,956,421.74%
MDxHealth SA ADR (MDXH)	2021-2022	600,809.09%
MicroCloud Hologram (HOLO)	2021-2022	131,516.22%
CareMax (CMAX)	2021-2022	20,957.69%
Destination XL (DXLG)	2021-2022	2,476.34%
Zivo Bioscience (ZIVO)	2021-2022	1,544.74%
Castellum (CTM)	2021-2022	1,331.82%
Alpha Metallurgical Resources (AMR)	2021-2022	1,245.02%
Sigma Lithium Resources (SGML)	2021-2022	1,028.8%
Peabody Energy (BTU)	2021-2022	973.99%
LakeShore Biopharma (LSB)	2021-2022	955.26%
Obsidian Energy (OBE)	2021-2022	891.04%
Hudson Technologies (HDSN)	2021-2022	854.72%
Target Hospitality (TH)	2021-2022	846.25%
Atlas Lithium Corporation Common Stock (ATLX)	2021-2022	833.33%
Empire Petroleum (EP)	2021-2022	831.85%
Birks (BGI)	2021-2022	822.2%
Weatherford International (WFRD)	2021-2022	757.96%
Permian Basin Royalty Trust (PBT)	2021-2022	750.31%
Baytex Energy (BTE)	2021-2022	719.97%
Applied Digital (APLD)	2021-2022	717.78%
CPI Card (PMTS)	2021-2022	713.53%
Aehr Test Systems (AEHR)	2021-2022	704%
CVR Partners (UAN)	2021-2022	681.7%
Kolibri Global Energy Inc Common stock (KGEI)	2021-2022	637.5%