America Movil SAB de CV ADR (AMX) had the lowest return between 2000 and 2002 by a large-cap US stock, returning -100%.

ASSET	YEARS	% RETURN
America Movil SAB de CV ADR (AMX)	2000-2002	-100%
Marvell Technology (MRVL)	2000-2002	-100%
Akamai Technologies (AKAM)	2000-2002	-99.5%
MicroStrategy (MSTR)	2000-2002	-98.69%
Booking (BKNG)	2000-2002	-96.95%
Insmed (INSM)	2000-2002	-96.22%
VeriSign (VRSN)	2000-2002	-96.05%
Telefonaktiebolaget LM Ericsson B ADR (ERIC)	2000-2002	-95.96%
ON Semiconductor (ON)	2000-2002	-93.77%
Corning (GLW)	2000-2002	-92.24%
F5 Networks (FFIV)	2000-2002	-91.14%
PTC (PTC)	2000-2002	-90.69%
MasTec (MTZ)	2000-2002	-90.11%
Illumina (ILMN)	2000-2002	-88.72%
Kratos Defense & Security Solutions (KTOS)	2000-2002	-86.95%
ArcelorMittal SA ADR (MT)	2000-2002	-86.08%
Incyte (INCY)	2000-2002	-86.04%
Leonardo DRS, Inc Common Stock (DRS)	2000-2002	-84.49%
Freedom (FRHC)	2000-2002	-83.77%
Ciena (CIEN)	2000-2002	-82.39%
Motorola Solutions (MSI)	2000-2002	-82.34%
U-Haul (UHAL)	2000-2002	-82.23%
Qualcomm (QCOM)	2000-2002	-81.74%
Quanta Services (PWR)	2000-2002	-81.42%
Align Technology (ALGN)	2000-2002	-81.29%

Large-cap stocks are treated as having a market cap of $10B+.