Coinbase Global (COIN) had the lowest return between 2016 and 2022 by a US stock in the S&P 500 (GSPC), returning -90.7%.

ASSET	YEARS	% RETURN
Coinbase Global (COIN)	2016-2022	-90.71%
Applovin (APP)	2016-2022	-84.96%
Carnival (CCL)	2016-2022	-82.95%
Norwegian Cruise Line (NCLH)	2016-2022	-78.74%
Robinhood Markets (HOOD)	2016-2022	-78.58%
Viatris (VTRS)	2016-2022	-77.56%
PG&E (PCG)	2016-2022	-67.51%
Warner Bros Discovery (WBD)	2016-2022	-63.72%
GE Aerospace (GE)	2016-2022	-60.26%
DoorDash, Inc Class A Common Stock (DASH)	2016-2022	-52.14%
Mohawk Industries (MHK)	2016-2022	-45.92%
Royal Caribbean Cruises (RCL)	2016-2022	-45.21%
Airbnb (ABNB)	2016-2022	-41.44%
Uber Technologies (UBER)	2016-2022	-41.12%
Western Digital (WDC)	2016-2022	-38.37%
Palantir Technologies Inc Class A Common Stock (PLTR)	2016-2022	-35.8%
Molson Coors Brewing (TAP)	2016-2022	-35.53%
United Airlines (UAL)	2016-2022	-32.43%
Delta Air Lines (DAL)	2016-2022	-26.84%
Incyte (INCY)	2016-2022	-24.58%
Expedia (EXPE)	2016-2022	-24.56%
Invesco (IVZ)	2016-2022	-24.53%
Kraft Heinz (KHC)	2016-2022	-23.82%
Fox Corp Class B (FOX)	2016-2022	-22.05%
Stanley Black & Decker (SWK)	2016-2022	-17.66%