TNF Pharmaceuticals (TNFA) had the lowest return between 2018 and 2020 by a US stock, returning -100%.

ASSET	YEARS	% RETURN
TNF Pharmaceuticals (TNFA)	2018-2020	-100%
MetroCity Bankshares (MCBS)	2018-2020	-100%
TOP Ships (TOPS)	2018-2020	-99.9%
Cenntro Electric (CENN)	2018-2020	-99.87%
InspireMD (NSPR)	2018-2020	-99.85%
BioRestorative Therapies (BRTX)	2018-2020	-99.79%
Seanergy Maritime (SHIP)	2018-2020	-99.78%
Globus Maritime (GLBS)	2018-2020	-99.51%
Sunshine Biopharma (SBFM)	2018-2020	-99.31%
Phio Pharmaceuticals (PHIO)	2018-2020	-99.16%
Salarius Pharmaceuticals (SLRX)	2018-2020	-98.9%
GameSquare (GAME)	2018-2020	-98.86%
PDS Biotechnology (PDSB)	2018-2020	-98.86%
Aytu BioScience (AYTU)	2018-2020	-98.67%
Plus Therapeutics (PSTV)	2018-2020	-98.65%
Titan Pharmaceuticals (TTNP)	2018-2020	-98.65%
Creative Medical Technology (CELZ)	2018-2020	-98.62%
Enveric Biosciences (ENVB)	2018-2020	-98.62%
XWELL (XWEL)	2018-2020	-98.54%
Ocugen (OCGN)	2018-2020	-98.51%
Sellas Life Sciences (SLS)	2018-2020	-98.45%
Sonnet Biotherapeutics (SONN)	2018-2020	-98%
Bridgeline Digital (BLIN)	2018-2020	-97.87%
Theriva Biologics (TOVX)	2018-2020	-97.83%
Traws Pharma (TRAW)	2018-2020	-97.78%