Kyrie Irving and Karl-Anthony Towns were tied for the most points in a game in 2021-22, with 60 points.

Interpreted as:

highest scoring by a player NBA regular-season games 2022

NAME	PTS	DATE	TM		OPP	MIN	REB	AST	STL	BLK	TOV	FGM	FGA	FG%	3PM	3PA	3P%	FTM	FTA	FT%	PF	+/-
Kyrie Irving	60	3/15/2022	BKN	@	ORL	35	6	4	4	1	1	20	31	64.5	8	12	66.7	12	13	92.3	3	+36
Karl-Anthony Towns	60	3/14/2022	MIN	@	SAS	36	17	3	1	0	6	19	31	61.3	7	11	63.6	15	16	93.8	5	+16
LeBron James	56	3/5/2022	LAL	vs	GSW	39	10	3	0	1	4	19	31	61.3	6	11	54.5	12	13	92.3	0	+13
Trae Young	56	1/3/2022	ATL	@	POR	37	4	14	0	0	4	17	26	65.4	7	12	58.3	15	15	100.0	1	+10
Kevin Durant	55	4/2/2022	BKN	@	ATL	42	7	3	1	0	4	19	28	67.9	8	10	80.0	9	11	81.8	1	+1
Jayson Tatum	54	3/6/2022	BOS	vs	BKN	41	5	3	0	0	2	16	30	53.3	8	15	53.3	14	17	82.4	4	+12
Kevin Durant	53	3/13/2022	BKN	vs	NYK	43	6	9	2	0	5	19	37	51.4	4	13	30.8	11	12	91.7	3	+11
Ja Morant	52	2/28/2022	MEM	vs	SAS	34	7	2	0	0	4	22	30	73.3	4	4	100.0	4	7	57.1	1	+23
Saddiq Bey	51	3/17/2022	DET	@	ORL	39	9	4	3	0	1	17	27	63.0	10	14	71.4	7	10	70.0	1	+11
Luka Doncic	51	2/10/2022	DAL	vs	LAC	40	9	6	1	1	7	17	26	65.4	7	14	50.0	10	14	71.4	4	+9
Jayson Tatum	51	1/23/2022	BOS	@	WAS	33	10	7	0	0	1	18	28	64.3	9	14	64.3	6	6	100.0	1	+31
Kevin Durant	51	12/12/2021	BKN	@	DET	41	7	9	1	2	5	16	31	51.6	5	10	50.0	14	15	93.3	5	+25
DeMar DeRozan	50	3/31/2022	CHI	vs	LAC	43	5	6	1	0	2	17	26	65.4	2	2	100.0	14	15	93.3	4	+19
LeBron James	50	3/11/2022	LAL	vs	WAS	36	7	6	0	1	3	18	25	72.0	6	9	66.7	8	8	100.0	3	+22
Kyrie Irving	50	3/8/2022	BKN	@	CHA	38	3	6	1	1	3	15	19	78.9	9	12	75.0	11	13	84.6	4	+14
Giannis Antetokounmpo	50	2/15/2022	MIL	vs	IND	36	14	4	0	0	3	17	21	81.0	2	3	66.7	14	18	77.8	3	+7
Joel Embiid	50	1/19/2022	PHI	vs	ORL	27	12	2	1	3	2	17	23	73.9	1	4	25.0	15	17	88.2	3	+24
Jaylen Brown	50	1/2/2022	BOS	vs	ORL	46	11	4	1	2	7	19	29	65.5	5	10	50.0	7	8	87.5	4	+10
Stephen Curry	50	11/8/2021	GSW	vs	ATL	35	7	10	4	1	2	14	28	50.0	9	19	47.4	13	13	100.0	0	+31
Anthony Edwards	49	4/7/2022	MIN	vs	SAS	39	6	8	1	0	2	16	28	57.1	6	14	42.9	11	14	78.6	2	+18
Devin Booker	49	3/24/2022	PHX	@	DEN	39	4	10	3	1	2	16	25	64.0	2	5	40.0	15	17	88.2	3	+16
Luka Doncic	49	2/17/2022	DAL	@	NOP	38	15	8	0	1	5	17	35	48.6	7	14	50.0	8	12	66.7	3	+21
Nikola Jokic	49	1/19/2022	DEN	vs	LAC	41	14	10	3	1	5	16	25	64.0	3	5	60.0	14	16	87.5	4	+15
Devin Booker	48	1/17/2022	PHX	@	SAS	35	5	6	3	0	0	18	33	54.5	5	13	38.5	7	8	87.5	2	+3
Anthony Edwards	48	11/10/2021	MIN	@	GSW	42	6	5	2	0	6	16	27	59.3	7	13	53.8	9	12	75.0	1	-3