DeMar DeRozan put up the most points in the fourth quarter in 2021-22, with 612 points.

Interpreted as:

most points by a player in the 4th-quarter NBA 2022

NAME	PTS	SEASON	TM	GP	MPG	PPG	RPG	APG	SPG	BPG	TPG	FGM	FGA	FG%	3PM	3PA	3P%	FTM	FTA	FT%	MIN	REB	AST	STL	BLK	TOV	PF	+/-
DeMar DeRozan	612	2021-22	CHI	74	8.9	8.3	1.5	1.3	0.3	0.1	0.5	3.0	5.5	54.6	0.2	0.5	44.1	2.1	2.4	86.1	659	111	93	20	5	35	53	+133
Giannis Antetokounmpo	528	2021-22	MIL	65	8.1	8.1	3.2	1.3	0.3	0.3	0.8	2.7	4.8	55.9	0.3	0.9	29.3	2.4	3.4	72.6	526	210	82	18	22	54	85	+141
Jayson Tatum	469	2021-22	BOS	72	8.4	6.5	1.8	0.9	0.3	0.1	0.8	2.1	4.6	45.3	0.6	1.7	35.0	1.8	2.1	87.2	605	128	62	22	9	59	57	+60
LeBron James	432	2021-22	LAL	55	9.5	7.9	2.1	1.8	0.4	0.3	0.7	3.0	6.1	48.7	0.7	2.4	30.8	1.2	1.5	75.3	525	113	97	23	15	41	43	+4
Trae Young	414	2021-22	ATL	74	6.6	5.6	0.7	1.3	0.1	0.0	0.7	1.8	4.1	43.1	0.5	1.7	31.2	1.5	1.7	88.8	492	52	99	9	0	54	31	-27
Buddy Hield	395	2021-22	TOT	78	8.6	5.1	1.2	0.5	0.2	0.0	0.4	1.7	3.8	45.3	1.1	2.5	42.1	0.6	0.6	93.6	669	90	37	17	3	35	71	-38
Jordan Clarkson	389	2021-22	UTA	79	8.1	4.9	1.0	0.6	0.3	0.0	0.5	1.8	4.0	43.6	0.7	2.2	33.9	0.7	0.8	83.9	639	79	49	22	3	38	52	+119
Joel Embiid	386	2021-22	PHI	64	6.5	6.0	2.1	0.7	0.2	0.5	0.6	1.9	3.9	47.6	0.3	0.9	33.3	2.0	2.4	81.9	417	135	43	14	30	39	61	+73
Immanuel Quickley	371	2021-22	NYK	76	9.0	4.9	1.1	1.5	0.3	0.0	0.5	1.6	3.8	41.4	0.8	2.1	38.3	0.9	1.0	88.2	685	85	112	23	0	39	77	+35
Stephen Curry	365	2021-22	GSW	58	8.3	6.3	1.4	1.4	0.3	0.1	0.7	2.2	4.9	44.7	1.1	3.1	35.6	0.9	1.0	89.3	480	79	82	16	5	42	37	+79
Nikola Jokic	364	2021-22	DEN	65	6.9	5.6	2.7	1.4	0.3	0.2	0.7	2.0	3.9	50.4	0.1	0.7	20.5	1.5	2.0	76.2	449	173	92	20	15	47	56	-3
Tyler Herro	361	2021-22	MIA	65	9.7	5.6	1.5	1.1	0.2	0.0	0.7	2.0	4.4	45.1	0.8	1.8	43.2	0.8	0.9	85.2	630	98	69	10	3	45	27	+63
Zach LaVine	359	2021-22	CHI	61	7.5	5.9	1.0	0.7	0.1	0.0	0.5	1.9	4.0	47.6	0.5	1.5	34.0	1.5	1.8	86.9	459	62	42	4	3	30	36	+22
Miles Bridges	357	2021-22	CHA	74	7.6	4.8	1.7	0.8	0.2	0.2	0.4	1.8	3.6	49.3	0.4	1.5	29.2	0.8	1.0	77.9	564	128	57	14	16	31	60	+113
Dejounte Murray	354	2021-22	SAS	65	8.1	5.4	1.7	1.6	0.5	0.0	0.7	2.2	4.6	47.0	0.2	0.9	25.9	0.9	1.2	72.2	527	113	107	31	1	43	42	+8
Donovan Mitchell	351	2021-22	UTA	63	7.3	5.6	0.9	1.2	0.4	0.0	0.8	2.0	4.7	41.1	0.5	2.0	26.8	1.1	1.4	80.0	461	57	76	23	2	49	54	+21
Anthony Edwards	349	2021-22	MIN	66	7.7	5.3	1.0	0.9	0.3	0.1	0.7	1.8	4.0	45.2	0.8	2.0	38.5	0.9	1.2	76.3	511	68	60	20	8	44	47	-53
Terry Rozier	341	2021-22	CHA	68	7.2	5.0	1.0	0.8	0.3	0.1	0.2	1.8	3.9	45.5	0.9	2.1	41.4	0.6	0.8	78.8	490	65	51	17	4	15	30	+120
Pascal Siakam	339	2021-22	TOR	66	8.9	5.1	2.3	1.1	0.3	0.2	0.7	1.9	3.9	47.3	0.2	0.5	33.3	1.3	1.8	70.9	590	155	74	19	10	43	78	+117
Kelly Oubre Jr.	335	2021-22	CHA	73	7.7	4.6	1.2	0.3	0.3	0.1	0.2	1.7	3.4	49.4	0.8	2.0	40.4	0.4	0.6	69.8	564	91	23	19	5	17	55	+86
Darius Garland	334	2021-22	CLE	67	8.7	5.0	0.9	1.9	0.3	0.0	0.8	1.8	4.2	43.4	0.4	1.4	31.5	0.9	1.1	88.7	582	57	124	17	1	56	37	-22
Luka Doncic	327	2021-22	DAL	61	7.4	5.4	2.0	1.5	0.3	0.1	0.6	1.9	4.2	45.1	0.6	1.7	36.5	0.9	1.3	70.4	451	122	92	17	8	39	53	+7
Khris Middleton	327	2021-22	MIL	60	8.2	5.5	1.6	1.0	0.2	0.1	0.9	1.7	4.0	43.2	0.6	1.8	32.7	1.4	1.6	86.5	490	94	62	13	5	53	60	+137
De'Aaron Fox	325	2021-22	SAC	56	8.1	5.8	0.9	1.1	0.3	0.1	0.7	2.1	4.4	48.2	0.1	0.9	16.7	1.4	1.8	76.2	454	52	64	14	5	41	63	-49
Tyrese Maxey	324	2021-22	PHI	71	8.6	4.6	0.7	0.9	0.1	0.1	0.2	1.6	3.2	49.1	0.5	1.1	48.1	0.9	1.0	84.7	608	53	63	10	8	17	42	+85