Matt Ryan had the most passing yards in a Week-4 game in 2013, with 421 yards versus the Patriots on September 29, 2013.

	NAME	YDS	DATE	TM		OPP	CMP	ATT	PCT	AVG	TD	INT	RTG	TD%	INT%	SCK	SCKY
1	Matt Ryan M. Ryan	421	9/29/2013	ATL	vs	NE	34	54	63.0	7.8	2	1	91.7	3.7	1.9	2	22
2	Drew Brees D. Brees	413	9/30/2013	NO	vs	MIA	30	39	76.9	10.6	4	0	144.5	10.3	0.0	2	16
3	Philip Rivers P. Rivers	401	9/29/2013	SD	vs	DAL	35	42	83.3	9.5	3	1	120.3	7.1	2.4	1	7
4	Ben Roethlisberger B. Roethlisberger	383	9/29/2013	PIT	@	MIN	36	51	70.6	7.5	1	1	90.6	2.0	2.0	5	26
5	Matt Schaub M. Schaub	355	9/29/2013	HOU	vs	SEA	31	49	63.3	7.2	2	2	81.6	4.1	4.1	4	30
6	Joe Flacco J. Flacco	347	9/29/2013	BAL	@	BUF	25	50	50.0	6.9	2	5	46.4	4.0	10.0	4	26
7	Peyton Manning P. Manning	327	9/29/2013	DEN	vs	PHI	28	34	82.4	9.6	4	0	146.0	11.8	0.0	1	6
8	Jay Cutler J. Cutler	317	9/29/2013	CHI	@	DET	27	47	57.4	6.7	2	3	65.6	4.3	6.4	3	31
9	Tom Brady T. Brady	316	9/29/2013	NE	@	ATL	20	31	64.5	10.2	2	0	119.8	6.5	0.0	0	0
10	Geno Smith G. Smith	289	9/29/2013	NYJ	@	TEN	23	34	67.6	8.5	1	2	79.2	2.9	5.9	5	50
11	Alex Smith A. Smith	288	9/29/2013	KC	vs	NYG	24	41	58.5	7.0	3	2	84.2	7.3	4.9	1	0
12	Brian Hoyer B. Hoyer	269	9/29/2013	CLE	vs	CIN	25	38	65.8	7.1	2	0	103.9	5.3	0.0	3	22
13	Andrew Luck A. Luck	257	9/29/2013	IND	@	JAX	21	35	60.0	7.3	2	1	89.8	5.7	2.9	2	14
14	Ryan Tannehill R. Tannehill	249	9/30/2013	MIA	@	NO	22	35	62.9	7.1	1	3	57.9	2.9	8.6	4	33
15	Michael Vick M. Vick	248	9/29/2013	PHI	@	DEN	14	27	51.9	9.2	0	0	83.6	0.0	0.0	3	13
16	Matt Cassel M. Cassel	248	9/29/2013	MIN	vs	PIT	16	25	64.0	9.9	2	0	123.4	8.0	0.0	1	0
17	Carson Palmer C. Palmer	248	9/29/2013	ARI	@	TB	21	38	55.3	6.5	1	2	62.2	2.6	5.3	1	8
18	Tony Romo T. Romo	246	9/29/2013	DAL	@	SD	27	37	73.0	6.6	2	0	108.6	5.4	0.0	3	19
19	Matthew Stafford M. Stafford	242	9/29/2013	DET	vs	CHI	23	35	65.7	6.9	1	1	83.3	2.9	2.9	1	14
20	Matt Flynn M. Flynn	227	9/29/2013	OAK	vs	WAS	21	32	65.6	7.1	1	1	83.7	3.1	3.1	7	33
21	Robert Griffin III R. Griffin III	227	9/29/2013	WAS	@	OAK	18	31	58.1	7.3	1	0	91.7	3.2	0.0	1	10
22	Eli Manning E. Manning	217	9/29/2013	NYG	@	KC	18	37	48.6	5.9	1	1	64.8	2.7	2.7	3	17
23	Andy Dalton A. Dalton	206	9/29/2013	CIN	@	CLE	23	42	54.8	4.9	0	1	58.2	0.0	2.4	2	3
24	Sam Bradford S. Bradford	202	9/26/2013	STL	vs	SF	19	41	46.3	4.9	1	1	59.2	2.4	2.4	5	32
25	Mike Glennon M. Glennon	193	9/29/2013	TB	vs	ARI	24	43	55.8	4.5	1	2	55.7	2.3	4.7	2	20

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Matt Ryan had the most passing yards in a Week-4 game in 2013, with 421 yards versus the Patriots on September 29, 2013.

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