The San Francisco 49ers have a 2-2 record against the spread as favorites in the 2025 regular-season and playoffs.
| TEAM | DATE | ATS | SEASON | TM | OPP | RESULT | SPREAD | ATS DIFF | O/U | O/U DIFF | TD | 1DWN | OFF | OPP OFF | 3DWN% | 4DWN% | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | 49ers | 9/7/2025 | 1-0 | 2025 |  SF | -139 | @ |  SEA | +117 | W 17-13 | -2.5 | +1.5 (Y) | 43.5 | -13.5 (U) | 2 | 24 | 384 | 230 | 50.0 | 100.0 |
| 2 | | 49ers | 9/14/2025 | 1-0 | 2025 | SF | -162 | @ |  NO | +137 | W 26-21 | -3 | +2 (Y) | 40.5 | +6.5 (O) | 3 | 23 | 344 | 307 | 53.3 | |
| 3 | | 49ers | 9/21/2025 | 0-1 | 2025 | SF | -123 | vs |  ARI | +103 | W 16-15 | -1.5 | -0.5 (N) | 44.5 | -13.5 (U) | 1 | 19 | 355 | 260 | 20.0 | 50.0 |
| 4 | | 49ers | 9/28/2025 | 0-1 | 2025 | SF | -178 | vs |  JAX | +144 | L 21-26 | -3.5 | -8.5 (N) | 45.5 | +1.5 (O) | 2 | 22 | 389 | 325 | 61.5 | 0.0 |
| Average | 12.5 | 2.0 | 22.0 | 368.0 | 280.5 | 48.1 | 20.0 | ||||||||||||||
| Total | 2-2 | 8 | 88 | 1,472 | 1,122 | 48.1 | 60.0 |
StatMuse has team, game-level data for spread records going back to the 1979 season.
More 49ers Stats
Team Rankings
PPG
20.0
22nd
OPP PPG
18.8
6th
RUSH YDS/G
88.0
28th
PASS YDS/G
287.3
2nd
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NFL 2025 Division Standings
| NFC East | W | L | T | PCT |
|---|---|---|---|---|
 Eagles | 4 | 0 | 0 | 1.000 |
 Commanders | 2 | 2 | 0 | .500 |
| NFC North | W | L | T | PCT |
 Lions | 3 | 1 | 0 | .750 |
 Packers | 2 | 1 | 1 | .625 |
| NFC South | W | L | T | PCT |
 Buccaneers | 3 | 1 | 0 | .750 |
 Falcons | 2 | 2 | 0 | .500 |
| NFC West | W | L | T | PCT |
| 49ers | 3 | 1 | 0 | .750 |
| Seahawks | 3 | 1 | 0 | .750 |
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