The San Francisco 49ers have a record of 23-24-2 against the spread against the NFC South since 2004.
| TEAM | DATE | ATS | TM | OPP | RESULT | SPREAD | ATS DIFF | O/U | O/U DIFF | TD | 1DWN | OFF | OPP OFF | 3DWN% | 4DWN% | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | 49ers | 9/12/2004 | 1-0 | vs | L 19-21 | +3 | +1 (Y) | 43.5 | -3.5 (U) | 2 | 21 | 359 | 227 | 41.2 | 100.0 | ||||
| 2 | | 49ers | 9/19/2004 | 1-0 | @ | L 27-30 | +7.5 | +4.5 (Y) | 42 | +15 (O) | 3 | 22 | 370 | 302 | 38.5 | |||||
| 3 | | 49ers | 11/14/2004 | 0-1 | vs | L 27-37 | -1 | -11 (N) | 41.5 | +22.5 (O) | 3 | 23 | 357 | 358 | 50.0 | 100.0 | ||||
| 4 | | 49ers | 11/21/2004 | 0-1 | @ | L 3-35 | +8 | -24 (N) | 42 | -4 (U) | 0 | 13 | 197 | 352 | 8.3 | 100.0 | ||||
| 5 | | 49ers | 10/30/2005 | 1-0 | vs | W 15-10 | +11 | +16 (Y) | 36 | -11 (U) | 0 | 9 | 208 | 275 | 12.5 | |||||
| 6 | | 49ers | 12/3/2006 | 0-1 | +260 | @ | -330 | L 10-34 | +7 | -17 (N) | 45 | -1 (U) | 1 | 10 | 202 | 375 | 27.3 | |||
| 7 | | 49ers | 10/28/2007 | 0-1 | +120 | vs | -140 | L 10-31 | +2.5 | -18.5 (N) | 40 | +1 (O) | 1 | 15 | 260 | 438 | 52.6 | 0.0 | ||
| 8 | | 49ers | 11/4/2007 | 0-1 | +175 | @ | -200 | L 16-20 | +3.5 | -0.5 (N) | 37 | -1 (U) | 1 | 16 | 251 | 286 | 23.1 | |||
| 9 | | 49ers | 12/2/2007 | 0-1 | +145 | @ | -165 | L 14-31 | +3 | -14 (N) | 35.5 | +9.5 (O) | 2 | 12 | 195 | 323 | 27.3 | 0.0 | ||
| 10 | | 49ers | 12/23/2007 | 1-0 | +230 | vs | -290 | W 21-19 | +6 | +8 (Y) | 36.5 | +3.5 (O) | 3 | 11 | 213 | 434 | 28.6 | |||
| 11 | | 49ers | 9/28/2008 | 0-1 | +175 | @ | -205 | L 17-31 | +4.5 | -9.5 (N) | 48 | 0 (P) | 1 | 20 | 312 | 467 | 30.0 | 100.0 | ||
| 12 | | 49ers | 10/11/2009 | 0-1 | -115 | vs | -105 | L 10-45 | -2.5 | -37.5 (N) | 40 | +15 (O) | 1 | 13 | 279 | 477 | 28.6 | 50.0 | ||
| 13 | | 49ers | 9/20/2010 | 1-0 | +190 | vs | -230 | L 22-25 | +5.5 | +2.5 (Y) | 44 | +3 (O) | 3 | 24 | 417 | 287 | 55.6 | |||
| 14 | | 49ers | 10/3/2010 | 1-0 | +260 | @ | -315 | L 14-16 | +7 | +5 (Y) | 42.5 | -12.5 (U) | 2 | 17 | 262 | 357 | 50.0 | 100.0 | ||
| 15 | | 49ers | 10/24/2010 | 0-1 | -130 | @ | +110 | L 20-23 | -2.5 | -5.5 (N) | 35.5 | +7.5 (O) | 2 | 15 | 282 | 379 | 30.8 | |||
| 16 | | 49ers | 11/21/2010 | 0-1 | -190 | vs | +170 | L 0-21 | -3.5 | -24.5 (N) | 42 | -21 (U) | 0 | 11 | 189 | 299 | 25.0 | 0.0 | ||
| 17 | | 49ers | 10/9/2011 | 1-0 | -150 | vs | +130 | W 48-3 | -3 | +42 (Y) | 41.5 | +9.5 (O) | 6 | 28 | 418 | 272 | 28.6 | 100.0 | ||
| 18 | | 49ers | 1/14/2012 | 1-0 | +145 | vs | -165 | W 36-32 | +3.5 | +7.5 (Y) | 47 | +21 (O) | 4 | 17 | 407 | 472 | 26.7 | |||
| 19 | | 49ers | 11/25/2012 | 1-0 | -140 | @ | +120 | W 31-21 | -2.5 | +7.5 (Y) | 50 | +2 (O) | 4 | 18 | 375 | 290 | 46.2 | |||
| 20 | | 49ers | 1/20/2013 | 0-0-1 | -205 | @ | +175 | W 28-24 | -4 | 0 (P) | 47.5 | +4.5 (O) | 4 | 21 | 373 | 477 | 33.3 | |||
| 21 | | 49ers | 11/10/2013 | 0-1 | -260 | vs | +220 | L 9-10 | -6 | -7 (N) | 43 | -24 (U) | 0 | 10 | 151 | 250 | 15.4 | |||
| 22 | | 49ers | 11/17/2013 | 0-0-1 | +155 | @ | -175 | L 20-23 | +3 | 0 (P) | 50 | -7 (U) | 2 | 12 | 196 | 387 | 40.0 | |||
| 23 | | 49ers | 12/15/2013 | 1-0 | -250 | @ | +210 | W 33-14 | -4.5 | +14.5 (Y) | 41 | +6 (O) | 3 | 22 | 376 | 183 | 40.0 | |||
| 24 | | 49ers | 12/23/2013 | 0-1 | -1000 | vs | +650 | W 34-24 | -14 | -4 (N) | 46 | +12 (O) | 4 | 20 | 379 | 402 | 44.4 | |||
| 25 | | 49ers | 1/12/2014 | 1-0 | -125 | @ | +105 | W 23-10 | -1 | +12 (Y) | 41.5 | -8.5 (U) | 2 | 21 | 315 | 325 | 42.9 | 0.0 | ||
| Average | 1.0 | 2.4 | 18.7 | 320.4 | 345.6 | 38.1 | 0.0 | |||||||||||||
| Total | 23-24-2 | 118 | 916 | 15,702 | 16,935 | 38.1 | 47.4 | |||||||||||||
StatMuse has team, game-level data for spread records going back to the 1979 season.
More NFL News
Former Dallas Cowboys defensive end Kneeland had early stage CTE at time of death
Cornerback Rasul Douglas agrees to a 1-year contract with the Commanders, AP source says
Teammates of Travis Kelce and others around sports attend his wedding to Taylor Swift
Chris Johnson seeking revival of Ice Bucket Challenge as he continues his fight against ALS
More 49ers Stats
Team Leaders 
PASS
2,167
Purdy
RUSH
1,202
McCaffrey
REC
924
McCaffrey
Team Rankings
PPG
25.7
10th
OPP PPG
21.8
13th
RUSH YDS/G
106.9
24th
PASS YDS/G
254.0
6th
NFL 2025 Leaders
NFL 2025 Rankings
NFL Fantasy 2025
NFL 2025 Betting
NFL 2025 Standings
| AFC East | W | L | T | PCT |
|---|---|---|---|---|
 Patriots - y | 14 | 3 | 0 | .824 |
 Bills - w | 12 | 5 | 0 | .706 |
 Dolphins - e | 7 | 10 | 0 | .412 |
 Jets - e | 3 | 14 | 0 | .176 |
| AFC North | W | L | T | PCT |
 Steelers - y | 10 | 7 | 0 | .588 |
 Ravens - e | 8 | 9 | 0 | .471 |
 Bengals - e | 6 | 11 | 0 | .353 |
 Browns - e | 5 | 12 | 0 | .294 |
| AFC South | W | L | T | PCT |
 Jaguars - y | 13 | 4 | 0 | .765 |
 Texans - w | 12 | 5 | 0 | .706 |
 Colts - e | 8 | 9 | 0 | .471 |
 Titans - e | 3 | 14 | 0 | .176 |
| AFC West | W | L | T | PCT |
 Broncos - z* | 14 | 3 | 0 | .824 |
 Chargers - w | 11 | 6 | 0 | .647 |
 Chiefs - e | 6 | 11 | 0 | .353 |
 Raiders - e | 3 | 14 | 0 | .176 |
| NFC East | W | L | T | PCT |
|---|---|---|---|---|
 Eagles - y | 11 | 6 | 0 | .647 |
 Cowboys - e | 7 | 9 | 1 | .441 |
 Commanders - e | 5 | 12 | 0 | .294 |
 Giants - e | 4 | 13 | 0 | .235 |
| NFC North | W | L | T | PCT |
 Bears - y | 11 | 6 | 0 | .647 |
 Packers - w | 9 | 7 | 1 | .559 |
 Vikings - e | 9 | 8 | 0 | .529 |
 Lions - e | 9 | 8 | 0 | .529 |
| NFC South | W | L | T | PCT |
 Panthers - y | 8 | 9 | 0 | .471 |
 Buccaneers - e | 8 | 9 | 0 | .471 |
 Falcons - e | 8 | 9 | 0 | .471 |
 Saints - e | 6 | 11 | 0 | .353 |
| NFC West | W | L | T | PCT |
 Seahawks - z* | 14 | 3 | 0 | .824 |
 Rams - w | 12 | 5 | 0 | .706 |
 49ers - w | 12 | 5 | 0 | .706 |
 Cardinals - e | 3 | 14 | 0 | .176 |