The San Francisco 49ers had their lowest point differential in a game against the Rams on November 9, 1958, with a -49-point differential.
Interpreted as:
49ers biggest losses in a regular-season game| TEAM | DIFF | DATE | TM | OPP | RESULT | TD | 1DWN | OFF | OPP OFF | 3DWN% | 4DWN% | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | 49ers | -49 | 11/9/1958 | @ | L 7-56 | 1 | 20 | 282 | 577 | ||||
| 2 | | 49ers | -45 | 10/12/1980 | @ | L 14-59 | 2 | 14 | 225 | 460 | ||||
| 3 | | 49ers | -42 | 10/29/1967 | vs | L 3-45 | 0 | 10 | 173 | 391 | ||||
| 4 | | 49ers | -41 | 10/1/2006 | @ | L 0-41 | 0 | 10 | 165 | 333 | 23.1 | |||
| 5 | | 49ers | -41 | 12/12/1965 | @ | L 20-61 | 3 | 19 | 330 | 584 | ||||
| 6 | | 49ers | -41 | 11/14/1954 | @ | L 7-48 | 1 | 16 | 349 | 474 | ||||
| 7 | | 49ers | -40 | 9/27/2015 | @ | L 7-47 | 1 | 10 | 156 | 446 | 33.3 | |||
| 8 | | 49ers | -39 | 9/18/2005 | @ | L 3-42 | 0 | 8 | 142 | 583 | 25.0 | |||
| 9 | | 49ers | -38 | 12/11/2005 | @ | L 3-41 | 0 | 8 | 113 | 438 | 16.7 | |||
| 10 | | 49ers | -38 | 11/30/2003 | @ | L 6-44 | 0 | 10 | 264 | 282 | 26.7 | 0.0 | ||
| 11 | | 49ers | -38 | 9/12/1999 | @ | L 3-41 | 0 | 11 | 203 | 344 | 7.1 | 50.0 | ||
| 12 | | 49ers | -38 | 11/3/1963 | vs | L 7-45 | 1 | 9 | 133 | 509 | ||||
| 13 | | 49ers | -35 | 10/11/2009 | vs | L 10-45 | 1 | 13 | 279 | 477 | 28.6 | 50.0 | ||
| 14 | | 49ers | -35 | 10/23/2005 | @ | L 17-52 | 2 | 9 | 194 | 457 | 25.0 | |||
| 15 | | 49ers | -35 | 11/30/1997 | @ | L 9-44 | 0 | 13 | 279 | 340 | 12.5 | 0.0 | ||
| 16 | | 49ers | -35 | 10/2/1955 | vs | L 3-38 | 0 | 8 | 139 | 357 | ||||
| 17 | | 49ers | -34 | 12/26/2004 | vs | L 7-41 | 1 | 12 | 189 | 441 | 30.0 | 100.0 | ||
| 18 | | 49ers | -34 | 9/26/2004 | @ | L 0-34 | 0 | 9 | 175 | 374 | 15.4 | 100.0 | ||
| 19 | | 49ers | -34 | 10/1/1967 | @ | L 7-41 | 1 | 15 | 240 | 524 | ||||
| 20 | | 49ers | -34 | 11/17/1963 | @ | L 14-48 | 2 | 10 | 224 | 568 | ||||
| 21 | | 49ers | -32 | 11/21/2004 | @ | L 3-35 | 0 | 13 | 197 | 352 | 8.3 | 100.0 | ||
| 22 | | 49ers | -32 | 10/2/1994 | vs | L 8-40 | 1 | 11 | 189 | 437 | 33.3 | 66.7 | ||
| 23 | | 49ers | -31 | 10/29/2006 | @ | L 10-41 | 1 | 12 | 248 | 402 | 30.0 | 0.0 | ||
| 24 | | 49ers | -31 | 9/30/1966 | @ | L 3-34 | 0 | 15 | 251 | 356 | ||||
| 25 | | 49ers | -31 | 9/29/1963 | @ | L 14-45 | 2 | 14 | 237 | 396 | ||||
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PPG
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OPP PPG
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| AFC East | W | L | T | PCT |
|---|---|---|---|---|
 Patriots - y | 14 | 3 | 0 | .824 |
 Bills - w | 12 | 5 | 0 | .706 |
 Dolphins - e | 7 | 10 | 0 | .412 |
 Jets - e | 3 | 14 | 0 | .176 |
| AFC North | W | L | T | PCT |
 Steelers - y | 10 | 7 | 0 | .588 |
 Ravens - e | 8 | 9 | 0 | .471 |
 Bengals - e | 6 | 11 | 0 | .353 |
 Browns - e | 5 | 12 | 0 | .294 |
| AFC South | W | L | T | PCT |
 Jaguars - y | 13 | 4 | 0 | .765 |
 Texans - w | 12 | 5 | 0 | .706 |
 Colts - e | 8 | 9 | 0 | .471 |
 Titans - e | 3 | 14 | 0 | .176 |
| AFC West | W | L | T | PCT |
 Broncos - z* | 14 | 3 | 0 | .824 |
 Chargers - w | 11 | 6 | 0 | .647 |
 Chiefs - e | 6 | 11 | 0 | .353 |
 Raiders - e | 3 | 14 | 0 | .176 |
| NFC East | W | L | T | PCT |
|---|---|---|---|---|
 Eagles - y | 11 | 6 | 0 | .647 |
 Cowboys - e | 7 | 9 | 1 | .441 |
 Commanders - e | 5 | 12 | 0 | .294 |
 Giants - e | 4 | 13 | 0 | .235 |
| NFC North | W | L | T | PCT |
 Bears - y | 11 | 6 | 0 | .647 |
 Packers - w | 9 | 7 | 1 | .559 |
 Vikings - e | 9 | 8 | 0 | .529 |
 Lions - e | 9 | 8 | 0 | .529 |
| NFC South | W | L | T | PCT |
 Panthers - y | 8 | 9 | 0 | .471 |
 Buccaneers - e | 8 | 9 | 0 | .471 |
 Falcons - e | 8 | 9 | 0 | .471 |
 Saints - e | 6 | 11 | 0 | .353 |
| NFC West | W | L | T | PCT |
 Seahawks - z* | 14 | 3 | 0 | .824 |
 Rams - w | 12 | 5 | 0 | .706 |
 49ers - w | 12 | 5 | 0 | .706 |
 Cardinals - e | 3 | 14 | 0 | .176 |
