The San Francisco 49ers had a 1-0 record against the spread when playing >0 games in Week 12 against the Panthers on November 24.
| TEAM | DATE | ATS | GP | TM | OPP | RESULT | SPREAD | ATS DIFF | O/U | O/U DIFF | TD | 1DWN | OFF | OPP OFF | 3DWN% | 4DWN% | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | 49ers | 11/24/2025 | 1-0 | 1 | -386 | vs | +307 | W 20-9 | -7.5 | +3.5 (Y) | 49.5 | -20.5 (U) | 2 | 23 | 340 | 230 | 53.8 | 100.0 | ||
| 2 | | 49ers | 11/24/2024 | 0-1 | 1 | +237 | @ | -292 | L 10-38 | +6 | -22 (N) | 45 | +3 (O) | 1 | 11 | 241 | 325 | 30.0 | 0.0 | ||
| 3 | | 49ers | 11/23/2023 | 1-0 | 1 | -334 | @ | +260 | W 31-13 | -7 | +11 (Y) | 43 | +1 (O) | 4 | 23 | 377 | 220 | 45.5 | |||
| 4 | | 49ers | 11/27/2022 | 1-0 | 1 | -426 | vs | +325 | W 13-0 | -8.5 | +4.5 (Y) | 43.5 | -30.5 (U) | 1 | 21 | 317 | 260 | 38.5 | 50.0 | ||
| 5 | | 49ers | 11/28/2021 | 1-0 | 1 | -200 | vs | +168 | W 34-26 | -4 | +4 (Y) | 49 | +11 (O) | 4 | 23 | 423 | 323 | 41.7 | |||
| 6 | | 49ers | 11/29/2020 | 1-0 | 1 | +196 | @ | -236 | W 23-20 | +5 | +8 (Y) | 44.5 | -1.5 (U) | 2 | 18 | 345 | 308 | 21.4 | 100.0 | ||
| 7 | | 49ers | 11/24/2019 | 1-0 | 1 | -174 | vs | +144 | W 37-8 | -3 | +26 (Y) | 48 | -3 (U) | 4 | 16 | 339 | 198 | 33.3 | |||
| 8 | | 49ers | 11/25/2018 | 0-1 | 1 | +115 | @ | -125 | L 9-27 | +2 | -16 (N) | 54.5 | -18.5 (U) | 1 | 23 | 342 | 412 | 12.5 | |||
| 9 | | 49ers | 11/26/2017 | 0-1 | 1 | +260 | vs | -290 | L 13-24 | +6.5 | -4.5 (N) | 44.5 | -7.5 (U) | 1 | 16 | 280 | 318 | 31.3 | 100.0 | ||
| 10 | | 49ers | 11/27/2016 | 0-0-1 | 1 | +290 | @ | -350 | L 24-31 | +7 | 0 (P) | 44.5 | +10.5 (O) | 3 | 25 | 475 | 358 | 50.0 | 100.0 | ||
| 11 | | 49ers | 11/29/2015 | 1-0 | 1 | +350 | vs | -430 | L 13-19 | +8 | +2 (Y) | 45 | -13 (U) | 1 | 17 | 368 | 337 | 0.0 | 50.0 | ||
| 12 | | 49ers | 11/23/2014 | 0-1 | 1 | -500 | vs | +400 | W 17-13 | -10 | -6 (N) | 44 | -14 (U) | 2 | 16 | 312 | 213 | 38.5 | 100.0 | ||
| 13 | | 49ers | 11/25/2013 | 1-0 | 1 | -250 | @ | +210 | W 27-6 | -5.5 | +15.5 (Y) | 46 | -13 (U) | 3 | 15 | 304 | 190 | 28.6 | 50.0 | ||
| 14 | | 49ers | 11/25/2012 | 1-0 | 1 | -140 | @ | +120 | W 31-21 | -2.5 | +7.5 (Y) | 50 | +2 (O) | 4 | 18 | 375 | 290 | 46.2 | |||
| 15 | | 49ers | 11/24/2011 | 0-1 | 1 | +155 | @ | -175 | L 6-16 | +3.5 | -6.5 (N) | 40 | -18 (U) | 0 | 12 | 170 | 253 | 16.7 | 50.0 | ||
| 16 | | 49ers | 11/29/2010 | 1-0 | 1 | -130 | @ | +110 | W 27-6 | -2 | +19 (Y) | 41 | -8 (U) | 3 | 26 | 386 | 203 | 53.8 | |||
| 17 | | 49ers | 11/29/2009 | 1-0 | 1 | -175 | vs | +155 | W 20-3 | -3.5 | +13.5 (Y) | 41.5 | -18.5 (U) | 2 | 15 | 284 | 357 | 50.0 | 100.0 | ||
| 18 | | 49ers | 11/23/2008 | 0-1 | 1 | +350 | @ | -450 | L 22-35 | +9.5 | -3.5 (N) | 46 | +11 (O) | 2 | 16 | 304 | 408 | 20.0 | |||
| 19 | | 49ers | 11/25/2007 | 1-0 | 1 | +450 | @ | -625 | W 37-31 | +10.5 | +16.5 (Y) | 37.5 | +30.5 (O) | 5 | 21 | 374 | 552 | 30.8 | 0.0 | ||
| 20 | | 49ers | 11/26/2006 | 1-0 | 1 | +180 | @ | -220 | L 17-20 | +4 | +1 (Y) | 44 | -7 (U) | 2 | 20 | 319 | 349 | 45.5 | |||
| 21 | | 49ers | 11/27/2005 | 0-1 | 1 | @ | L 22-33 | +8 | -3 (N) | 42.5 | +12.5 (O) | 3 | 15 | 261 | 461 | 20.0 | 100.0 | ||||
| 22 | | 49ers | 11/28/2004 | 0-1 | 1 | vs | L 17-24 | -1 | -8 (N) | 37.5 | +3.5 (O) | 2 | 16 | 224 | 200 | 31.3 | |||||
| 23 | | 49ers | 11/23/2003 | 0-1 | 1 | @ | L 10-20 | +4 | -6 (N) | 41 | -11 (U) | 1 | 13 | 192 | 379 | 25.0 | 100.0 | ||||
| 24 | | 49ers | 11/25/2002 | 0-1 | 1 | vs | L 17-38 | -7 | -28 (N) | 38 | +17 (O) | 2 | 24 | 409 | 343 | 45.0 | 25.0 | ||||
| 25 | | 49ers | 12/2/2001 | 1-0 | 1 | vs | W 35-0 | -8 | +27 (Y) | 42 | -7 (U) | 5 | 26 | 409 | 191 | 66.7 | 0.0 | ||||
WAS
STLResults may be incomplete. StatMuse has complete team, game-level data for spread records going back to the 1979 season.
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More 49ers Stats
Team Leaders 
PASS
2,167
Purdy
RUSH
1,202
McCaffrey
REC
924
McCaffrey
Team Rankings
PPG
25.7
10th
OPP PPG
21.8
13th
RUSH YDS/G
106.9
24th
PASS YDS/G
254.0
6th
NFL 2025 Leaders
NFL 2025 Rankings
NFL Fantasy 2025
NFL 2025 Betting
NFL 2025 Standings
| AFC East | W | L | T | PCT |
|---|---|---|---|---|
 Patriots - y | 14 | 3 | 0 | .824 |
 Bills - w | 12 | 5 | 0 | .706 |
 Dolphins - e | 7 | 10 | 0 | .412 |
 Jets - e | 3 | 14 | 0 | .176 |
| AFC North | W | L | T | PCT |
 Steelers - y | 10 | 7 | 0 | .588 |
 Ravens - e | 8 | 9 | 0 | .471 |
 Bengals - e | 6 | 11 | 0 | .353 |
 Browns - e | 5 | 12 | 0 | .294 |
| AFC South | W | L | T | PCT |
 Jaguars - y | 13 | 4 | 0 | .765 |
 Texans - w | 12 | 5 | 0 | .706 |
 Colts - e | 8 | 9 | 0 | .471 |
 Titans - e | 3 | 14 | 0 | .176 |
| AFC West | W | L | T | PCT |
 Broncos - z* | 14 | 3 | 0 | .824 |
 Chargers - w | 11 | 6 | 0 | .647 |
 Chiefs - e | 6 | 11 | 0 | .353 |
 Raiders - e | 3 | 14 | 0 | .176 |
| NFC East | W | L | T | PCT |
|---|---|---|---|---|
 Eagles - y | 11 | 6 | 0 | .647 |
 Cowboys - e | 7 | 9 | 1 | .441 |
 Commanders - e | 5 | 12 | 0 | .294 |
 Giants - e | 4 | 13 | 0 | .235 |
| NFC North | W | L | T | PCT |
 Bears - y | 11 | 6 | 0 | .647 |
 Packers - w | 9 | 7 | 1 | .559 |
 Vikings - e | 9 | 8 | 0 | .529 |
 Lions - e | 9 | 8 | 0 | .529 |
| NFC South | W | L | T | PCT |
 Panthers - y | 8 | 9 | 0 | .471 |
 Buccaneers - e | 8 | 9 | 0 | .471 |
 Falcons - e | 8 | 9 | 0 | .471 |
 Saints - e | 6 | 11 | 0 | .353 |
| NFC West | W | L | T | PCT |
 Seahawks - z* | 14 | 3 | 0 | .824 |
 Rams - w | 12 | 5 | 0 | .706 |
 49ers - w | 12 | 5 | 0 | .706 |
 Cardinals - e | 3 | 14 | 0 | .176 |