The San Francisco 49ers have a record of 3-7 against the spread against the Cardinals at home since 2017.
| TEAM | DATE | ATS | TM | OPP | RESULT | SPREAD | ATS DIFF | O/U | O/U DIFF | TD | 1DWN | OFF | OPP OFF | 3DWN% | 4DWN% | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | 49ers | 11/5/2017 | 0-1 | +118 | vs | -128 | L 10-20 | +2.5 | -7.5 (N) | 39.5 | -9.5 (U) | 1 | 17 | 329 | 368 | 35.3 | 0.0 | ||
| 2 | | 49ers | 10/7/2018 | 0-1 | -156 | vs | +146 | L 18-28 | -3 | -13 (N) | 40.5 | +5.5 (O) | 3 | 33 | 447 | 220 | 58.8 | 50.0 | ||
| 3 | | 49ers | 11/17/2019 | 1-0 | -470 | vs | +351 | W 36-26 | -9.5 | +0.5 (Y) | 44 | +18 (O) | 5 | 26 | 442 | 266 | 46.2 | 0.0 | ||
| 4 | | 49ers | 9/13/2020 | 0-1 | -312 | vs | +245 | L 20-24 | -6.5 | -10.5 (N) | 48 | -4 (U) | 2 | 18 | 366 | 404 | 18.2 | 0.0 | ||
| 5 | | 49ers | 11/7/2021 | 0-1 | -247 | vs | +199 | L 17-31 | -5.5 | -19.5 (N) | 44.5 | +3.5 (O) | 2 | 22 | 337 | 437 | 40.0 | |||
| 6 | | 49ers | 1/8/2023 | 1-0 | -1057 | vs | +693 | W 38-13 | -14.5 | +10.5 (Y) | 39.5 | +11.5 (O) | 5 | 21 | 311 | 255 | 46.2 | 0.0 | ||
| 7 | | 49ers | 10/1/2023 | 1-0 | -1106 | vs | +692 | W 35-16 | -14.5 | +4.5 (Y) | 44 | +7 (O) | 5 | 30 | 395 | 362 | 60.0 | 100.0 | ||
| 8 | | 49ers | 10/6/2024 | 0-1 | -350 | vs | +278 | L 23-24 | -7.5 | -8.5 (N) | 48.5 | -1.5 (U) | 2 | 22 | 384 | 358 | 54.5 | 0.0 | ||
| 9 | | 49ers | 9/21/2025 | 0-1 | -123 | vs | +103 | W 16-15 | -1.5 | -0.5 (N) | 44.5 | -13.5 (U) | 1 | 19 | 355 | 260 | 20.0 | 50.0 | ||
| 10 | | 49ers | 9/27/2026 | 0-1 | -394 | vs | +308 | W 36-30 | -7.5 | -1.5 (N) | 48.5 | +17.5 (O) | 5 | 23 | 437 | 365 | 62.5 | |||
| Average | 3.0 | 3.1 | 23.1 | 380.3 | 329.5 | 43.5 | 0.0 | |||||||||||||
| Total | 3-7 | 31 | 231 | 3,803 | 3,295 | 43.5 | 23.1 |
SF
ARIStatMuse has team, game-level data for spread records going back to the 1979 season.
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More 49ers Stats
Team Leaders 
PASS
1,196
Purdy
RUSH
286
McCaffrey
REC
326
Evans
Team Rankings
PPG
30.8
3rd
OPP PPG
18.6
3rd
RUSH YDS/G
128.6
8th
PASS YDS/G
239.2
15th
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WAS
ATL
LV
DAL
MIN
NFL 2026 Leaders
NFL 2026 Rankings
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NFL 2026 Standings
| NFC East | W | L | T | PCT |
|---|---|---|---|---|
3 | 1 | 1 | .700 | |
2 | 3 | 0 | .400 | |
2 | 3 | 0 | .400 | |
1 | 3 | 1 | .300 | |
| NFC North | W | L | T | PCT |
5 | 0 | 0 | 1.000 | |
3 | 2 | 0 | .600 | |
3 | 2 | 0 | .600 | |
3 | 2 | 0 | .600 | |
| NFC South | W | L | T | PCT |
2 | 2 | 0 | .500 | |
2 | 3 | 0 | .400 | |
1 | 4 | 0 | .200 | |
1 | 4 | 0 | .200 | |
| NFC West | W | L | T | PCT |
5 | 0 | 0 | 1.000 | |
3 | 2 | 0 | .600 | |
2 | 2 | 0 | .500 | |
1 | 4 | 0 | .200 |
Giants
Eagles
Packers
Lions
Bears
Panthers
Buccaneers
Saints| AFC East | W | L | T | PCT |
|---|---|---|---|---|
3 | 1 | 0 | .750 | |
3 | 2 | 0 | .600 | |
2 | 3 | 0 | .400 | |
0 | 5 | 0 | .000 | |
| AFC North | W | L | T | PCT |
4 | 1 | 0 | .800 | |
3 | 2 | 0 | .600 | |
3 | 2 | 0 | .600 | |
3 | 2 | 0 | .600 | |
| AFC South | W | L | T | PCT |
4 | 1 | 0 | .800 | |
2 | 3 | 0 | .400 | |
1 | 4 | 0 | .200 | |
0 | 5 | 0 | .000 | |
| AFC West | W | L | T | PCT |
4 | 0 | 0 | 1.000 | |
3 | 2 | 0 | .600 | |
3 | 2 | 0 | .600 | |
0 | 5 | 0 | .000 |
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