The San Francisco 49ers had a record of 21-21 against the spread against the NFC West at home between the 2008 and 2021 seasons.
| TEAM | DATE | ATS | TM | OPP | RESULT | SPREAD | ATS DIFF | O/U | O/U DIFF | TD | 1DWN | OFF | OPP OFF | 3DWN% | 4DWN% | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | 49ers | 9/7/2008 | 0-1 | +115 | vs | -135 | L 13-23 | +2.5 | -7.5 (N) | 41.5 | -5.5 (U) | 1 | 13 | 291 | 285 | 37.5 | |||
| 2 | | 49ers | 10/26/2008 | 0-1 | -245 | vs | +200 | L 13-34 | -5 | -26 (N) | 41 | +6 (O) | 1 | 21 | 388 | 261 | 46.7 | 0.0 | ||
| 3 | | 49ers | 11/16/2008 | 1-0 | -300 | vs | +250 | W 35-16 | -7 | +12 (Y) | 43.5 | +7.5 (O) | 5 | 19 | 334 | 406 | 45.5 | |||
| 4 | | 49ers | 9/20/2009 | 1-0 | -120 | vs | +100 | W 23-10 | -1 | +12 (Y) | 39.5 | -6.5 (U) | 2 | 16 | 379 | 283 | 33.3 | |||
| 5 | | 49ers | 10/4/2009 | 1-0 | -475 | vs | +350 | W 35-0 | -9.5 | +25.5 (Y) | 37 | -2 (U) | 5 | 13 | 228 | 177 | 30.8 | |||
| 6 | | 49ers | 12/14/2009 | 1-0 | +185 | vs | -225 | W 24-9 | +3 | +18 (Y) | 44.5 | -11.5 (U) | 3 | 18 | 327 | 245 | 50.0 | |||
| 7 | | 49ers | 11/14/2010 | 0-1 | -210 | vs | +180 | W 23-20 | -5 | -2 (N) | 38.5 | +4.5 (O) | 2 | 19 | 421 | 332 | 0.0 | 100.0 | ||
| 8 | | 49ers | 12/12/2010 | 1-0 | -220 | vs | +180 | W 40-21 | -5 | +14 (Y) | 41.5 | +19.5 (O) | 4 | 10 | 336 | 361 | 41.2 | |||
| 9 | | 49ers | 1/2/2011 | 1-0 | -250 | vs | +210 | W 38-7 | -6.5 | +24.5 (Y) | 39 | +6 (O) | 5 | 16 | 362 | 279 | 18.2 | |||
| 10 | | 49ers | 9/11/2011 | 1-0 | -250 | vs | +210 | W 33-17 | -6 | +10 (Y) | 37.5 | +12.5 (O) | 3 | 12 | 209 | 219 | 8.3 | |||
| 11 | | 49ers | 11/20/2011 | 1-0 | -600 | vs | +450 | W 23-7 | -10 | +6 (Y) | 41 | -11 (U) | 2 | 25 | 431 | 229 | 38.1 | 100.0 | ||
| 12 | | 49ers | 12/4/2011 | 1-0 | -800 | vs | +600 | W 26-0 | -14 | +12 (Y) | 38 | -12 (U) | 2 | 18 | 389 | 157 | 28.6 | |||
| 13 | | 49ers | 10/18/2012 | 0-1 | -380 | vs | +310 | W 13-6 | -9 | -2 (N) | 37.5 | -18.5 (U) | 1 | 18 | 313 | 251 | 27.3 | |||
| 14 | | 49ers | 11/11/2012 | 0-1 | -800 | vs | +600 | T 24-24 | -13.5 | -13.5 (N) | 38 | +10 (O) | 3 | 25 | 341 | 458 | 18.2 | 100.0 | ||
| 15 | | 49ers | 12/30/2012 | 0-1 | -1600 | vs | +1000 | W 27-13 | -16.5 | -2.5 (N) | 38.5 | +1.5 (O) | 3 | 20 | 407 | 262 | 28.6 | 100.0 | ||
| 16 | | 49ers | 10/13/2013 | 1-0 | -550 | vs | +400 | W 32-20 | -10 | +2 (Y) | 40.5 | +11.5 (O) | 3 | 20 | 387 | 403 | 28.6 | 100.0 | ||
| 17 | | 49ers | 12/1/2013 | 1-0 | -370 | vs | +310 | W 23-13 | -7.5 | +2.5 (Y) | 41 | -5 (U) | 2 | 20 | 338 | 312 | 33.3 | |||
| 18 | | 49ers | 12/8/2013 | 0-1 | -135 | vs | +115 | W 19-17 | -2.5 | -0.5 (N) | 41 | -5 (U) | 1 | 19 | 318 | 264 | 38.5 | |||
| 19 | | 49ers | 11/2/2014 | 0-1 | -600 | vs | +450 | L 10-13 | -10.5 | -13.5 (N) | 44 | -21 (U) | 1 | 20 | 263 | 193 | 25.0 | |||
| 20 | | 49ers | 11/27/2014 | 0-1 | -130 | vs | +110 | L 3-19 | -1 | -17 (N) | 40 | -18 (U) | 0 | 16 | 164 | 379 | 36.4 | |||
| 21 | | 49ers | 12/28/2014 | 0-1 | -300 | vs | +240 | W 20-17 | -6 | -3 (N) | 38 | -1 (U) | 2 | 18 | 395 | 397 | 41.7 | |||
| 22 | | 49ers | 10/22/2015 | 0-1 | +225 | vs | -300 | L 3-20 | +6 | -11 (N) | 42 | -19 (U) | 0 | 8 | 142 | 388 | 9.1 | |||
| 23 | | 49ers | 11/29/2015 | 1-0 | +350 | vs | -430 | L 13-19 | +8 | +2 (Y) | 45 | -13 (U) | 1 | 17 | 368 | 337 | 0.0 | 50.0 | ||
| 24 | | 49ers | 1/3/2016 | 1-0 | +145 | vs | -165 | W 19-16 | +3 | +6 (Y) | 38.5 | -3.5 (U) | 1 | 21 | 458 | 364 | 44.4 | 0.0 | ||
| 25 | | 49ers | 9/12/2016 | 1-0 | +125 | vs | -145 | W 28-0 | +3 | +31 (Y) | 42.5 | -14.5 (U) | 4 | 28 | 320 | 185 | 47.1 | 50.0 | ||
| Average | 1.2 | 2.5 | 19.2 | 338.0 | 311.4 | 34.1 | 0.0 | |||||||||||||
| Total | 21-21 | 103 | 806 | 14,195 | 13,080 | 34.1 | 56.1 | |||||||||||||
STLStatMuse has team, game-level data for spread records going back to the 1979 season.
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Team Leaders 
PASS
2,167
Purdy
RUSH
1,202
McCaffrey
REC
924
McCaffrey
Team Rankings
PPG
25.7
10th
OPP PPG
21.8
13th
RUSH YDS/G
106.9
24th
PASS YDS/G
254.0
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NFL 2025 Leaders
NFL 2025 Rankings
NFL Fantasy 2025
NFL 2025 Betting
NFL 2025 Standings
| AFC East | W | L | T | PCT |
|---|---|---|---|---|
 Patriots - y | 14 | 3 | 0 | .824 |
 Bills - w | 12 | 5 | 0 | .706 |
 Dolphins - e | 7 | 10 | 0 | .412 |
 Jets - e | 3 | 14 | 0 | .176 |
| AFC North | W | L | T | PCT |
 Steelers - y | 10 | 7 | 0 | .588 |
 Ravens - e | 8 | 9 | 0 | .471 |
 Bengals - e | 6 | 11 | 0 | .353 |
 Browns - e | 5 | 12 | 0 | .294 |
| AFC South | W | L | T | PCT |
 Jaguars - y | 13 | 4 | 0 | .765 |
 Texans - w | 12 | 5 | 0 | .706 |
 Colts - e | 8 | 9 | 0 | .471 |
 Titans - e | 3 | 14 | 0 | .176 |
| AFC West | W | L | T | PCT |
 Broncos - z* | 14 | 3 | 0 | .824 |
 Chargers - w | 11 | 6 | 0 | .647 |
 Chiefs - e | 6 | 11 | 0 | .353 |
 Raiders - e | 3 | 14 | 0 | .176 |
| NFC East | W | L | T | PCT |
|---|---|---|---|---|
 Eagles - y | 11 | 6 | 0 | .647 |
 Cowboys - e | 7 | 9 | 1 | .441 |
 Commanders - e | 5 | 12 | 0 | .294 |
 Giants - e | 4 | 13 | 0 | .235 |
| NFC North | W | L | T | PCT |
 Bears - y | 11 | 6 | 0 | .647 |
 Packers - w | 9 | 7 | 1 | .559 |
 Vikings - e | 9 | 8 | 0 | .529 |
 Lions - e | 9 | 8 | 0 | .529 |
| NFC South | W | L | T | PCT |
 Panthers - y | 8 | 9 | 0 | .471 |
 Buccaneers - e | 8 | 9 | 0 | .471 |
 Falcons - e | 8 | 9 | 0 | .471 |
 Saints - e | 6 | 11 | 0 | .353 |
| NFC West | W | L | T | PCT |
 Seahawks - z* | 14 | 3 | 0 | .824 |
 Rams - w | 12 | 5 | 0 | .706 |
 49ers - w | 12 | 5 | 0 | .706 |
 Cardinals - e | 3 | 14 | 0 | .176 |