The San Francisco 49ers have a 3-4 record in the regular-season and playoffs at home against the Panthers since 2000.
| OPP | REC | W% | GP | W | L | T | TD | PTS | PPG | OPP PTS | OPP PPG | 1DWN | 3DWN% | 4DWN% | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 3-4 | .429 | 7 | 3 | 4 | 0 | 18 | 156 | 22.3 | 144 | 20.6 | 135 | 36.8 | 50.0 | |
| 2 | 15-10 | .600 | 25 | 15 | 10 | 0 | 72 | 620 | 24.8 | 495 | 19.8 | 515 | 37.0 | 53.8 | |
| 3 | 15-10-1 | .596 | 26 | 15 | 10 | 1 | 74 | 625 | 24.0 | 485 | 18.7 | 494 | 37.4 | 58.3 | |
| 4 | 6-3 | .667 | 9 | 6 | 3 | 0 | 19 | 185 | 20.6 | 177 | 19.7 | 175 | 40.2 | 77.8 | |
| 5 | 3-4 | .429 | 7 | 3 | 4 | 0 | 19 | 159 | 22.7 | 187 | 26.7 | 138 | 40.9 | 16.7 | |
| 6 | 6-2 | .750 | 8 | 6 | 2 | 0 | 24 | 217 | 27.1 | 113 | 14.1 | 167 | 47.1 | 55.6 | |
| 7 | 7-1 | .875 | 8 | 7 | 1 | 0 | 27 | 221 | 27.6 | 166 | 20.8 | 184 | 41.0 | 66.7 | |
| 8 | 2-5 | .286 | 7 | 2 | 5 | 0 | 16 | 150 | 21.4 | 192 | 27.4 | 141 | 41.0 | 42.9 | |
| 9 | 4-2 | .667 | 6 | 4 | 2 | 0 | 15 | 132 | 22.0 | 116 | 19.3 | 107 | 34.2 | 57.1 | |
| 10 | 11-14 | .440 | 25 | 11 | 14 | 0 | 51 | 516 | 20.6 | 530 | 21.2 | 427 | 34.0 | 52.4 | |
| 11 | 5-5 | .500 | 10 | 5 | 5 | 0 | 30 | 258 | 25.8 | 239 | 23.9 | 186 | 45.6 | 40.0 | |
| 12 | 4-4 | .500 | 8 | 4 | 4 | 0 | 18 | 176 | 22.0 | 188 | 23.5 | 148 | 39.6 | 33.3 | |
| 13 | 6-2 | .750 | 8 | 6 | 2 | 0 | 22 | 187 | 23.4 | 115 | 14.4 | 147 | 29.2 | 40.0 | |
| 14 | 3-4 | .429 | 7 | 3 | 4 | 0 | 20 | 173 | 24.7 | 171 | 24.4 | 135 | 51.0 | 0.0 | |
| 15 | 4-1 | .800 | 5 | 4 | 1 | 0 | 10 | 97 | 19.4 | 69 | 13.8 | 94 | 40.0 | 33.3 |
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More 49ers Stats
Team Leaders 
PASS
2,167
Purdy
RUSH
1,202
McCaffrey
REC
924
McCaffrey
Team Rankings
PPG
25.7
10th
OPP PPG
21.8
13th
RUSH YDS/G
106.9
24th
PASS YDS/G
254.0
6th
NFL 2025 Leaders
NFL 2025 Rankings
NFL Fantasy 2025
NFL 2025 Betting
NFL 2025 Standings
| AFC East | W | L | T | PCT |
|---|---|---|---|---|
 Patriots - y | 14 | 3 | 0 | .824 |
 Bills - w | 12 | 5 | 0 | .706 |
 Dolphins - e | 7 | 10 | 0 | .412 |
 Jets - e | 3 | 14 | 0 | .176 |
| AFC North | W | L | T | PCT |
 Steelers - y | 10 | 7 | 0 | .588 |
 Ravens - e | 8 | 9 | 0 | .471 |
 Bengals - e | 6 | 11 | 0 | .353 |
 Browns - e | 5 | 12 | 0 | .294 |
| AFC South | W | L | T | PCT |
 Jaguars - y | 13 | 4 | 0 | .765 |
 Texans - w | 12 | 5 | 0 | .706 |
 Colts - e | 8 | 9 | 0 | .471 |
 Titans - e | 3 | 14 | 0 | .176 |
| AFC West | W | L | T | PCT |
 Broncos - z* | 14 | 3 | 0 | .824 |
 Chargers - w | 11 | 6 | 0 | .647 |
 Chiefs - e | 6 | 11 | 0 | .353 |
 Raiders - e | 3 | 14 | 0 | .176 |
| NFC East | W | L | T | PCT |
|---|---|---|---|---|
 Eagles - y | 11 | 6 | 0 | .647 |
 Cowboys - e | 7 | 9 | 1 | .441 |
 Commanders - e | 5 | 12 | 0 | .294 |
 Giants - e | 4 | 13 | 0 | .235 |
| NFC North | W | L | T | PCT |
 Bears - y | 11 | 6 | 0 | .647 |
 Packers - w | 9 | 7 | 1 | .559 |
 Vikings - e | 9 | 8 | 0 | .529 |
 Lions - e | 9 | 8 | 0 | .529 |
| NFC South | W | L | T | PCT |
 Panthers - y | 8 | 9 | 0 | .471 |
 Buccaneers - e | 8 | 9 | 0 | .471 |
 Falcons - e | 8 | 9 | 0 | .471 |
 Saints - e | 6 | 11 | 0 | .353 |
| NFC West | W | L | T | PCT |
 Seahawks - z* | 14 | 3 | 0 | .824 |
 Rams - w | 12 | 5 | 0 | .706 |
 49ers - w | 12 | 5 | 0 | .706 |
 Cardinals - e | 3 | 14 | 0 | .176 |