
The San Francisco 49ers had a record of 2-1 in the regular-season and playoffs at home versus the Bills between the 1992 and 2001 seasons.
| OPP | REC | W% | GP | W | L | T | TD | PTS | PPG | OPP PTS | OPP PPG | 1DWN | 3DWN% | 4DWN% | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 2-1 | .667 | 3 | 2 | 1 | 0 | 12 | 93 | 31.0 | 51 | 17.0 | 70 | 52.3 | 40.0 | |
| 2 | 7-3 | .700 | 10 | 7 | 3 | 0 | 34 | 298 | 29.8 | 197 | 19.7 | 208 | 45.6 | 54.5 | |
| 3 | 10-0 | 1.000 | 10 | 10 | 0 | 0 | 40 | 346 | 34.6 | 141 | 14.1 | 223 | 37.4 | 58.3 | |
| 4 | 8-2 | .800 | 10 | 8 | 2 | 0 | 35 | 268 | 26.8 | 168 | 16.8 | 212 | 44.0 | 66.7 | |
| 5 | 3-2 | .600 | 5 | 3 | 2 | 0 | 10 | 89 | 17.8 | 94 | 18.8 | 91 | 34.4 | 75.0 | |
| 6 | 2-0 | 1.000 | 2 | 2 | 0 | 0 | 7 | 48 | 24.0 | 3 | 1.5 | 41 | 51.9 | 75.0 | |
| 7 | 2-0 | 1.000 | 2 | 2 | 0 | 0 | 8 | 62 | 31.0 | 30 | 15.0 | 47 | 58.3 | ||
| 8 | 4-0 | 1.000 | 4 | 4 | 0 | 0 | 14 | 104 | 26.0 | 46 | 11.5 | 96 | 56.8 | 66.7 | |
| 9 | 1-1 | .500 | 2 | 1 | 1 | 0 | 4 | 40 | 20.0 | 39 | 19.5 | 46 | 47.8 | 100.0 | |
| 10 | 3-2 | .600 | 5 | 3 | 2 | 0 | 14 | 113 | 22.6 | 102 | 20.4 | 96 | 30.6 | 100.0 | |
| 11 | 4-0 | 1.000 | 4 | 4 | 0 | 0 | 19 | 141 | 35.3 | 88 | 22.0 | 93 | 42.0 | 50.0 | |
| 12 | 2-0 | 1.000 | 2 | 2 | 0 | 0 | 7 | 55 | 27.5 | 34 | 17.0 | 44 | 46.4 | ||
| 13 | 2-0 | 1.000 | 2 | 2 | 0 | 0 | 7 | 49 | 24.5 | 29 | 14.5 | 39 | 38.1 | 66.7 | |
| 14 | 1-1 | .500 | 2 | 1 | 1 | 0 | 4 | 31 | 15.5 | 32 | 16.0 | 37 | 42.3 | ||
| 15 | 3-0 | 1.000 | 3 | 3 | 0 | 0 | 12 | 95 | 31.7 | 16 | 5.3 | 70 | 45.0 | 0.0 | |
| 16 | 1-1 | .500 | 2 | 1 | 1 | 0 | 10 | 72 | 36.0 | 48 | 24.0 | 52 | 50.0 | 75.0 | |
| 17 | 2-0 | 1.000 | 2 | 2 | 0 | 0 | 10 | 76 | 38.0 | 36 | 18.0 | 43 | 52.0 | 100.0 | |
| 18 | 2-0 | 1.000 | 2 | 2 | 0 | 0 | 8 | 61 | 30.5 | 15 | 7.5 | 53 | 36.4 | 100.0 | |
| 19 | 2-0 | 1.000 | 2 | 2 | 0 | 0 | 9 | 66 | 33.0 | 36 | 18.0 | 47 | 42.3 | ||
| 20 | 1-0 | 1.000 | 1 | 1 | 0 | 0 | 4 | 28 | 28.0 | 3 | 3.0 | 21 | 38.5 | 100.0 | |
| 21 | 3-4 | .429 | 7 | 3 | 4 | 0 | 19 | 158 | 22.6 | 168 | 24.0 | 149 | 35.0 | 60.0 | |
| 22 | 1-3 | .250 | 4 | 1 | 3 | 0 | 6 | 60 | 15.0 | 97 | 24.3 | 74 | 30.5 | 66.7 | |
| 23 | 1-0 | 1.000 | 1 | 1 | 0 | 0 | 5 | 38 | 38.0 | 20 | 20.0 | 22 | 41.7 | 100.0 | |
| 24 | 1-0 | 1.000 | 1 | 1 | 0 | 0 | 5 | 36 | 36.0 | 30 | 30.0 | 26 | 33.3 | 100.0 | |
| 25 | 1-0 | 1.000 | 1 | 1 | 0 | 0 | 4 | 34 | 34.0 | 31 | 31.0 | 36 | 54.5 | ||
More 49ers Stats
Team Leaders
PASS
2,167
Purdy
RUSH
1,202
McCaffrey
REC
924
McCaffrey
Team Rankings
PPG
25.7
10th
OPP PPG
21.8
13th
RUSH YDS/G
106.9
24th
PASS YDS/G
254.0
6th
NFL 2025 Leaders
NFL 2025 Rankings
NFL Fantasy 2025
NFL 2025 Betting
NFL 2025 Standings
| AFC East | W | L | T | PCT |
|---|---|---|---|---|
14 | 3 | 0 | .824 | |
12 | 5 | 0 | .706 | |
7 | 10 | 0 | .412 | |
3 | 14 | 0 | .176 | |
| AFC North | W | L | T | PCT |
10 | 7 | 0 | .588 | |
8 | 9 | 0 | .471 | |
6 | 11 | 0 | .353 | |
5 | 12 | 0 | .294 | |
| AFC South | W | L | T | PCT |
13 | 4 | 0 | .765 | |
12 | 5 | 0 | .706 | |
8 | 9 | 0 | .471 | |
3 | 14 | 0 | .176 | |
| AFC West | W | L | T | PCT |
14 | 3 | 0 | .824 | |
11 | 6 | 0 | .647 | |
6 | 11 | 0 | .353 | |
3 | 14 | 0 | .176 |
| NFC East | W | L | T | PCT |
|---|---|---|---|---|
11 | 6 | 0 | .647 | |
7 | 9 | 1 | .441 | |
5 | 12 | 0 | .294 | |
4 | 13 | 0 | .235 | |
| NFC North | W | L | T | PCT |
11 | 6 | 0 | .647 | |
9 | 7 | 1 | .559 | |
9 | 8 | 0 | .529 | |
9 | 8 | 0 | .529 | |
| NFC South | W | L | T | PCT |
8 | 9 | 0 | .471 | |
8 | 9 | 0 | .471 | |
8 | 9 | 0 | .471 | |
6 | 11 | 0 | .353 | |
| NFC West | W | L | T | PCT |
14 | 3 | 0 | .824 | |
12 | 5 | 0 | .706 | |
12 | 5 | 0 | .706 | |
3 | 14 | 0 | .176 |









