The San Francisco 49ers had their most tackles in a game in 2022 on December 24, 2022 and on October 16, 2022, with 52 tackles.
Interpreted as:
49ers most tackles in a regular-season game 2022| TEAM | TKL | DATE | TM | OPP | RESULT | AST | COMB | SCK | SCKY | INT | INT YDS | INT TD | FF | FR | FR TD | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | 49ers | 52 | 12/24/2022 | vs | W 37-20 | 37 | 89 | 2.0 | 19 | 1 | 0 | 0 | 1 | 1 | 0 | ||
| 2 | | 49ers | 52 | 10/16/2022 | @ | L 14-28 | 26 | 78 | 2.0 | 8 | 0 | 0 | 0 | 1 | 0 | 0 | ||
| 3 | | 49ers | 51 | 11/21/2022 | @ | W 38-10 | 12 | 63 | 3.0 | 30 | 2 | 0 | 0 | 1 | 0 | 0 | ||
| 4 | | 49ers | 50 | 10/3/2022 | vs | W 24-9 | 18 | 68 | 7.0 | 54 | 1 | 52 | 1 | 1 | 1 | 0 | ||
| 5 | | 49ers | 48 | 12/11/2022 | vs | W 35-7 | 32 | 80 | 0.0 | 0 | 2 | 36 | 0 | 2 | 1 | 0 | ||
| 6 | | 49ers | 44 | 12/15/2022 | @ | W 21-13 | 16 | 60 | 3.0 | 31 | 0 | 0 | 0 | 2 | 1 | 0 | ||
| 7 | | 49ers | 43 | 9/25/2022 | @ | L 10-11 | 38 | 81 | 4.0 | 24 | 0 | 0 | 0 | 2 | 0 | 0 | ||
| 8 | | 49ers | 39 | 10/23/2022 | vs | L 23-44 | 18 | 57 | 1.0 | 6 | 1 | 2 | 0 | 0 | 1 | 0 | ||
| 9 | | 49ers | 39 | 10/9/2022 | @ | W 37-15 | 32 | 71 | 6.0 | 31 | 1 | 41 | 1 | 1 | 0 | 0 | ||
| 10 | | 49ers | 38 | 9/11/2022 | @ | L 10-19 | 14 | 52 | 2.0 | 16 | 1 | 1 | 0 | 0 | 0 | 0 | ||
| 11 | | 49ers | 37 | 1/8/2023 | vs | W 38-13 | 23 | 60 | 3.0 | 15 | 3 | 60 | 0 | 1 | 1 | 0 | ||
| 12 | | 49ers | 37 | 11/27/2022 | vs | W 13-0 | 23 | 60 | 1.0 | 7 | 0 | 0 | 0 | 2 | 2 | 0 | ||
| 13 | | 49ers | 35 | 1/1/2023 | @ | W 37-34 | 35 | 70 | 0.0 | 0 | 2 | 56 | 0 | 0 | 0 | 0 | ||
| 14 | | 49ers | 35 | 11/13/2022 | vs | W 22-16 | 19 | 54 | 3.0 | 9 | 1 | 6 | 0 | 1 | 0 | 0 | ||
| 15 | | 49ers | 34 | 10/30/2022 | @ | W 31-14 | 25 | 59 | 2.0 | 20 | 0 | 0 | 0 | 0 | 0 | 0 | ||
| 16 | | 49ers | 34 | 9/18/2022 | vs | W 27-7 | 18 | 52 | 2.0 | 17 | 2 | 23 | 0 | 0 | 1 | 0 | ||
| 17 | | 49ers | 28 | 12/4/2022 | vs | W 33-17 | 11 | 39 | 3.0 | 20 | 3 | 28 | 0 | 1 | 1 | 1 |
CHIStatMuse has team, game-level data for tackles going back to the 2001 season.
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More 49ers Stats
Team Leaders 
PASS
2,167
Purdy
RUSH
1,202
McCaffrey
REC
924
McCaffrey
Team Rankings
PPG
25.7
10th
OPP PPG
21.8
13th
RUSH YDS/G
106.9
24th
PASS YDS/G
254.0
6th
NFL 2025 Leaders
NFL 2025 Rankings
NFL Fantasy 2025
NFL 2025 Betting
NFL 2025 Standings
| AFC East | W | L | T | PCT |
|---|---|---|---|---|
 Patriots - y | 14 | 3 | 0 | .824 |
 Bills - w | 12 | 5 | 0 | .706 |
 Dolphins - e | 7 | 10 | 0 | .412 |
 Jets - e | 3 | 14 | 0 | .176 |
| AFC North | W | L | T | PCT |
 Steelers - y | 10 | 7 | 0 | .588 |
 Ravens - e | 8 | 9 | 0 | .471 |
 Bengals - e | 6 | 11 | 0 | .353 |
 Browns - e | 5 | 12 | 0 | .294 |
| AFC South | W | L | T | PCT |
 Jaguars - y | 13 | 4 | 0 | .765 |
 Texans - w | 12 | 5 | 0 | .706 |
 Colts - e | 8 | 9 | 0 | .471 |
 Titans - e | 3 | 14 | 0 | .176 |
| AFC West | W | L | T | PCT |
 Broncos - z* | 14 | 3 | 0 | .824 |
 Chargers - w | 11 | 6 | 0 | .647 |
 Chiefs - e | 6 | 11 | 0 | .353 |
 Raiders - e | 3 | 14 | 0 | .176 |
| NFC East | W | L | T | PCT |
|---|---|---|---|---|
 Eagles - y | 11 | 6 | 0 | .647 |
 Cowboys - e | 7 | 9 | 1 | .441 |
 Commanders - e | 5 | 12 | 0 | .294 |
 Giants - e | 4 | 13 | 0 | .235 |
| NFC North | W | L | T | PCT |
 Bears - y | 11 | 6 | 0 | .647 |
 Packers - w | 9 | 7 | 1 | .559 |
 Vikings - e | 9 | 8 | 0 | .529 |
 Lions - e | 9 | 8 | 0 | .529 |
| NFC South | W | L | T | PCT |
 Panthers - y | 8 | 9 | 0 | .471 |
 Buccaneers - e | 8 | 9 | 0 | .471 |
 Falcons - e | 8 | 9 | 0 | .471 |
 Saints - e | 6 | 11 | 0 | .353 |
| NFC West | W | L | T | PCT |
 Seahawks - z* | 14 | 3 | 0 | .824 |
 Rams - w | 12 | 5 | 0 | .706 |
 49ers - w | 12 | 5 | 0 | .706 |
 Cardinals - e | 3 | 14 | 0 | .176 |