The San Francisco 49ers have a 5-3 record in the regular-season and playoffs versus the Jaguars all-time.
| TEAM | DATE | REC | TM | OPP | RESULT | W% | TD | 1DWN | OFF | OPP OFF | 3DWN% | 4DWN% | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | 49ers | 9/12/1999 | 0-1 | @ | L 3-41 | .000 | 0 | 11 | 203 | 344 | 7.1 | 50.0 | ||
| 2 | | 49ers | 12/18/2005 | 0-1 | @ | L 9-10 | .000 | 0 | 11 | 217 | 336 | 7.7 | 0.0 | ||
| 3 | | 49ers | 11/29/2009 | 1-0 | vs | W 20-3 | 1.000 | 2 | 15 | 284 | 357 | 50.0 | 100.0 | ||
| 4 | | 49ers | 10/27/2013 | 1-0 | @ | W 42-10 | 1.000 | 6 | 25 | 398 | 318 | 66.7 | 100.0 | ||
| 5 | | 49ers | 12/24/2017 | 1-0 | vs | W 44-33 | 1.000 | 6 | 26 | 369 | 472 | 66.7 | |||
| 6 | | 49ers | 11/21/2021 | 1-0 | @ | W 30-10 | 1.000 | 3 | 25 | 333 | 200 | 50.0 | 100.0 | ||
| 7 | | 49ers | 11/12/2023 | 1-0 | @ | W 34-3 | 1.000 | 4 | 20 | 437 | 221 | 33.3 | 50.0 | ||
| 8 | | 49ers | 9/28/2025 | 0-1 | vs | L 21-26 | .000 | 2 | 22 | 389 | 325 | 61.5 | 0.0 | ||
| Average | .625 | 2.9 | 19.4 | 328.8 | 321.6 | 42.3 | 8.6 | ||||||||
| Total | 5-3 | .625 | 23 | 155 | 2,630 | 2,573 | 42.3 | 60.0 |
More 49ers Stats
Team Leaders 
PASS
2,151
Jones
RUSH
1,039
McCaffrey
REC
849
McCaffrey
Team Rankings
PPG
26.1
9th
OPP PPG
21.3
12th
RUSH YDS/G
104.3
25th
PASS YDS/G
259.2
5th
NFL 2025 Leaders
NFL 2025 Rankings
NFL Fantasy 2025
NFL 2025 Betting
NFL 2025 Standings
| AFC East | W | L | T | PCT |
|---|---|---|---|---|
 Patriots - x | 12 | 3 | 0 | .800 |
 Bills - x | 11 | 4 | 0 | .733 |
 Dolphins - e | 6 | 9 | 0 | .400 |
 Jets - e | 3 | 12 | 0 | .200 |
| AFC North | W | L | T | PCT |
9 | 6 | 0 | .600 | |
7 | 8 | 0 | .467 | |
 Bengals - e | 5 | 10 | 0 | .333 |
 Browns - e | 3 | 12 | 0 | .200 |
| AFC South | W | L | T | PCT |
 Jaguars - x | 11 | 4 | 0 | .733 |
 Texans - x | 11 | 5 | 0 | .688 |
 Colts - e | 8 | 7 | 0 | .533 |
 Titans - e | 3 | 12 | 0 | .200 |
| AFC West | W | L | T | PCT |
 Broncos - y | 13 | 3 | 0 | .813 |
 Chargers - x | 11 | 5 | 0 | .688 |
 Chiefs - e | 6 | 10 | 0 | .375 |
 Raiders - e | 2 | 13 | 0 | .133 |
Steelers
Ravens| NFC East | W | L | T | PCT |
|---|---|---|---|---|
 Eagles - y | 10 | 5 | 0 | .667 |
 Cowboys - e | 7 | 8 | 1 | .469 |
 Commanders - e | 4 | 12 | 0 | .250 |
 Giants - e | 2 | 13 | 0 | .133 |
| NFC North | W | L | T | PCT |
 Bears - x | 11 | 4 | 0 | .733 |
 Packers - x | 9 | 5 | 1 | .633 |
 Vikings - e | 8 | 8 | 0 | .500 |
 Lions - e | 8 | 8 | 0 | .500 |
| NFC South | W | L | T | PCT |
8 | 7 | 0 | .533 | |
7 | 8 | 0 | .467 | |
 Falcons - e | 6 | 9 | 0 | .400 |
 Saints - e | 5 | 10 | 0 | .333 |
| NFC West | W | L | T | PCT |
 Seahawks - x | 12 | 3 | 0 | .800 |
 49ers - x | 11 | 4 | 0 | .733 |
 Rams - x | 11 | 4 | 0 | .733 |
 Cardinals - e | 3 | 12 | 0 | .200 |
Panthers
Buccaneers
