The San Francisco 49ers have a record of 3-3 in the regular-season and playoffs versus the Patriots since 2000.
| TEAM | DATE | REC | TM | OPP | RESULT | W% | TD | 1DWN | OFF | OPP OFF | 3DWN% | 4DWN% | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | 49ers | 1/2/2005 | 0-1 | @ | L 7-21 | .000 | 1 | 15 | 318 | 405 | 37.5 | 50.0 | ||
| 2 | | 49ers | 10/5/2008 | 0-1 | vs | L 21-30 | .000 | 3 | 12 | 199 | 377 | 11.1 | 0.0 | ||
| 3 | | 49ers | 12/16/2012 | 1-0 | @ | W 41-34 | 1.000 | 5 | 19 | 388 | 520 | 35.7 | 50.0 | ||
| 4 | | 49ers | 11/20/2016 | 0-1 | vs | L 17-30 | .000 | 2 | 20 | 299 | 444 | 35.7 | |||
| 5 | | 49ers | 10/25/2020 | 1-0 | @ | W 33-6 | 1.000 | 4 | 26 | 467 | 241 | 55.6 | |||
| 6 | | 49ers | 9/29/2024 | 1-0 | vs | W 30-13 | 1.000 | 3 | 19 | 431 | 216 | 53.8 | |||
| Average | .500 | 3.0 | 18.5 | 350.3 | 367.2 | 38.7 | 12.5 | ||||||||
| Total | 3-3 | .500 | 18 | 111 | 2,102 | 2,203 | 38.7 | 37.5 |
More 49ers Stats
Team Leaders 
PASS
402
Purdy
RUSH
83
McCaffrey
REC
112
Robinson
Team Rankings
PPG
25.7
10th
OPP PPG
21.8
13th
RUSH YDS/G
106.9
24th
PASS YDS/G
254.0
6th
NFL 2025 Leaders
NFL 2025 Rankings
NFL Fantasy 2025
NFL 2025 Betting
NFL 2025 Standings
| AFC East | W | L | T | PCT |
|---|---|---|---|---|
 Patriots - y | 14 | 3 | 0 | .824 |
 Bills - w | 12 | 5 | 0 | .706 |
 Dolphins - e | 7 | 10 | 0 | .412 |
 Jets - e | 3 | 14 | 0 | .176 |
| AFC North | W | L | T | PCT |
 Steelers - y | 10 | 7 | 0 | .588 |
 Ravens - e | 8 | 9 | 0 | .471 |
 Bengals - e | 6 | 11 | 0 | .353 |
 Browns - e | 5 | 12 | 0 | .294 |
| AFC South | W | L | T | PCT |
 Jaguars - y | 13 | 4 | 0 | .765 |
 Texans - w | 12 | 5 | 0 | .706 |
 Colts - e | 8 | 9 | 0 | .471 |
 Titans - e | 3 | 14 | 0 | .176 |
| AFC West | W | L | T | PCT |
 Broncos - z* | 14 | 3 | 0 | .824 |
 Chargers - w | 11 | 6 | 0 | .647 |
 Chiefs - e | 6 | 11 | 0 | .353 |
 Raiders - e | 3 | 14 | 0 | .176 |
| NFC East | W | L | T | PCT |
|---|---|---|---|---|
 Eagles - y | 11 | 6 | 0 | .647 |
 Cowboys - e | 7 | 9 | 1 | .441 |
 Commanders - e | 5 | 12 | 0 | .294 |
 Giants - e | 4 | 13 | 0 | .235 |
| NFC North | W | L | T | PCT |
 Bears - y | 11 | 6 | 0 | .647 |
 Packers - w | 9 | 7 | 1 | .559 |
 Vikings - e | 9 | 8 | 0 | .529 |
 Lions - e | 9 | 8 | 0 | .529 |
| NFC South | W | L | T | PCT |
 Panthers - y | 8 | 9 | 0 | .471 |
 Buccaneers - e | 8 | 9 | 0 | .471 |
 Falcons - e | 8 | 9 | 0 | .471 |
 Saints - e | 6 | 11 | 0 | .353 |
| NFC West | W | L | T | PCT |
 Seahawks - z* | 14 | 3 | 0 | .824 |
 Rams - w | 12 | 5 | 0 | .706 |
 49ers - w | 12 | 5 | 0 | .706 |
 Cardinals - e | 3 | 14 | 0 | .176 |
