The San Francisco 49ers have an 8-4 record against the NFC East in the regular-season and playoffs on the road since 2017.
| TEAM | DATE | REC | TM | OPP | RESULT | W% | TD | 1DWN | OFF | OPP OFF | 3DWN% | 4DWN% | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | 49ers | 10/15/2017 | 0-1 | @ | L 24-26 | .000 | 3 | 21 | 335 | 419 | 35.3 | 50.0 | ||
| 2 | | 49ers | 10/29/2017 | 0-1 | @ | L 10-33 | .000 | 1 | 14 | 238 | 304 | 20.0 | |||
| 3 | | 49ers | 10/20/2019 | 1-0 | @ | W 9-0 | 1.000 | 0 | 17 | 283 | 154 | 43.8 | 50.0 | ||
| 4 | | 49ers | 9/27/2020 | 1-0 | @ | W 36-9 | 1.000 | 4 | 29 | 420 | 231 | 66.7 | |||
| 5 | | 49ers | 12/20/2020 | 0-1 | @ | L 33-41 | .000 | 4 | 28 | 458 | 291 | 40.0 | 100.0 | ||
| 6 | | 49ers | 9/19/2021 | 1-0 | @ | W 17-11 | 1.000 | 2 | 23 | 306 | 328 | 42.9 | 100.0 | ||
| 7 | | 49ers | 1/16/2022 | 1-0 | @ | W 23-17 | 1.000 | 2 | 21 | 341 | 307 | 46.2 | |||
| 8 | | 49ers | 1/29/2023 | 0-1 | @ | L 7-31 | .000 | 1 | 11 | 164 | 269 | 25.0 | 0.0 | ||
| 9 | | 49ers | 12/3/2023 | 1-0 | @ | W 42-19 | 1.000 | 6 | 24 | 456 | 333 | 72.7 | 100.0 | ||
| 10 | | 49ers | 12/31/2023 | 1-0 | @ | W 27-10 | 1.000 | 3 | 28 | 408 | 225 | 44.4 | 0.0 | ||
| 11 | | 49ers | 11/2/2025 | 1-0 | @ | W 34-24 | 1.000 | 4 | 25 | 380 | 296 | 54.5 | 100.0 | ||
| 12 | | 49ers | 1/11/2026 | 1-0 | @ | W 23-19 | 1.000 | 3 | 20 | 361 | 307 | 54.5 | |||
| Average | .667 | 2.8 | 21.8 | 345.8 | 288.7 | 44.7 | 6.8 | ||||||||
| Total | 8-4 | .667 | 33 | 261 | 4,150 | 3,464 | 44.7 | 54.5 |
WASMore 49ers Stats
Team Leaders 
PASS
2,167
Purdy
RUSH
1,202
McCaffrey
REC
924
McCaffrey
Team Rankings
PPG
25.7
10th
OPP PPG
21.8
13th
RUSH YDS/G
106.9
24th
PASS YDS/G
254.0
6th
NFL 2025 Leaders
NFL 2025 Rankings
NFL Fantasy 2025
NFL 2025 Betting
NFL 2025 Standings
| AFC East | W | L | T | PCT |
|---|---|---|---|---|
 Patriots - y | 14 | 3 | 0 | .824 |
 Bills - w | 12 | 5 | 0 | .706 |
 Dolphins - e | 7 | 10 | 0 | .412 |
 Jets - e | 3 | 14 | 0 | .176 |
| AFC North | W | L | T | PCT |
 Steelers - y | 10 | 7 | 0 | .588 |
 Ravens - e | 8 | 9 | 0 | .471 |
 Bengals - e | 6 | 11 | 0 | .353 |
 Browns - e | 5 | 12 | 0 | .294 |
| AFC South | W | L | T | PCT |
 Jaguars - y | 13 | 4 | 0 | .765 |
 Texans - w | 12 | 5 | 0 | .706 |
 Colts - e | 8 | 9 | 0 | .471 |
 Titans - e | 3 | 14 | 0 | .176 |
| AFC West | W | L | T | PCT |
 Broncos - z* | 14 | 3 | 0 | .824 |
 Chargers - w | 11 | 6 | 0 | .647 |
 Chiefs - e | 6 | 11 | 0 | .353 |
 Raiders - e | 3 | 14 | 0 | .176 |
| NFC East | W | L | T | PCT |
|---|---|---|---|---|
 Eagles - y | 11 | 6 | 0 | .647 |
 Cowboys - e | 7 | 9 | 1 | .441 |
 Commanders - e | 5 | 12 | 0 | .294 |
 Giants - e | 4 | 13 | 0 | .235 |
| NFC North | W | L | T | PCT |
 Bears - y | 11 | 6 | 0 | .647 |
 Packers - w | 9 | 7 | 1 | .559 |
 Vikings - e | 9 | 8 | 0 | .529 |
 Lions - e | 9 | 8 | 0 | .529 |
| NFC South | W | L | T | PCT |
 Panthers - y | 8 | 9 | 0 | .471 |
 Buccaneers - e | 8 | 9 | 0 | .471 |
 Falcons - e | 8 | 9 | 0 | .471 |
 Saints - e | 6 | 11 | 0 | .353 |
| NFC West | W | L | T | PCT |
 Seahawks - z* | 14 | 3 | 0 | .824 |
 Rams - w | 12 | 5 | 0 | .706 |
 49ers - w | 12 | 5 | 0 | .706 |
 Cardinals - e | 3 | 14 | 0 | .176 |
