The San Francisco 49ers lost to the Buffalo Bills, 35 to 10, on December 1, 2024. With the loss, the 49ers moved to 5-7 on the season.
| TEAM | DATE | TM | OPP | RESULT | TD | 1DWN | OFF | OPP OFF | 3DWN% | 4DWN% | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | 49ers | 12/1/2024 | @ | L 10-35 | 1 | 15 | 239 | 372 | 30.0 | 100.0 | ||
| 2 | | 49ers | 12/7/2020 | vs | L 24-34 | 3 | 24 | 402 | 449 | 54.5 | 0.0 | ||
| 3 | | 49ers | 10/16/2016 | @ | L 16-45 | 1 | 16 | 300 | 492 | 23.1 | 0.0 | ||
| 4 | | 49ers | 10/7/2012 | vs | W 45-3 | 6 | 29 | 621 | 204 | 63.6 | 100.0 | ||
| 5 | | 49ers | 11/30/2008 | @ | W 10-3 | 1 | 12 | 195 | 350 | 46.7 | |||
| 6 | | 49ers | 12/26/2004 | vs | L 7-41 | 1 | 12 | 189 | 441 | 30.0 | 100.0 | ||
| 7 | | 49ers | 12/2/2001 | vs | W 35-0 | 5 | 26 | 409 | 191 | 66.7 | 0.0 | ||
| 8 | | 49ers | 10/4/1998 | @ | L 21-26 | 3 | 23 | 377 | 352 | 46.2 | |||
| 9 | | 49ers | 12/3/1995 | vs | W 27-17 | 3 | 18 | 323 | 275 | 31.3 | 50.0 | ||
| 10 | | 49ers | 9/13/1992 | vs | L 31-34 | 4 | 26 | 598 | 488 | 61.5 | 100.0 | ||
| 11 | | 49ers | 12/17/1989 | vs | W 21-10 | 3 | 18 | 283 | 301 | ||||
| 12 | | 49ers | 12/11/1983 | @ | W 23-10 | 2 | 19 | 310 | 303 | ||||
| 13 | | 49ers | 12/21/1980 | vs | L 13-18 | 2 | 19 | 298 | 267 | ||||
| 14 | | 49ers | 9/24/1972 | @ | L 20-27 | 2 | 10 | 202 | 233 |
More 49ers Stats
Team Leaders 
PASS
2,151
Jones
RUSH
1,039
McCaffrey
REC
849
McCaffrey
Team Rankings
PPG
26.1
9th
OPP PPG
21.3
11th
RUSH YDS/G
104.3
25th
PASS YDS/G
259.2
5th
NFL 2025 Leaders
NFL 2025 Rankings
NFL Fantasy 2025
NFL 2025 Betting
NFL 2025 Standings
| AFC East | W | L | T | PCT |
|---|---|---|---|---|
 Patriots - x | 13 | 3 | 0 | .813 |
 Bills - x | 11 | 4 | 0 | .733 |
 Dolphins - e | 7 | 9 | 0 | .438 |
 Jets - e | 3 | 13 | 0 | .188 |
| AFC North | W | L | T | PCT |
9 | 7 | 0 | .563 | |
8 | 8 | 0 | .500 | |
 Bengals - e | 6 | 10 | 0 | .375 |
 Browns - e | 4 | 12 | 0 | .250 |
| AFC South | W | L | T | PCT |
 Jaguars - x | 12 | 4 | 0 | .750 |
 Texans - x | 11 | 5 | 0 | .688 |
 Colts - e | 8 | 8 | 0 | .500 |
 Titans - e | 3 | 13 | 0 | .188 |
| AFC West | W | L | T | PCT |
 Broncos - y | 13 | 3 | 0 | .813 |
 Chargers - w | 11 | 5 | 0 | .688 |
 Chiefs - e | 6 | 10 | 0 | .375 |
 Raiders - e | 2 | 14 | 0 | .125 |
Steelers
Ravens| NFC East | W | L | T | PCT |
|---|---|---|---|---|
 Eagles - y | 10 | 5 | 0 | .667 |
 Cowboys - e | 7 | 8 | 1 | .469 |
 Commanders - e | 4 | 12 | 0 | .250 |
 Giants - e | 3 | 13 | 0 | .188 |
| NFC North | W | L | T | PCT |
 Bears - y | 11 | 4 | 0 | .733 |
 Packers - w | 9 | 6 | 1 | .594 |
 Vikings - e | 8 | 8 | 0 | .500 |
 Lions - e | 8 | 8 | 0 | .500 |
| NFC South | W | L | T | PCT |
8 | 8 | 0 | .500 | |
7 | 9 | 0 | .438 | |
 Falcons - e | 6 | 9 | 0 | .400 |
 Saints - e | 6 | 10 | 0 | .375 |
| NFC West | W | L | T | PCT |
 Seahawks - x | 13 | 3 | 0 | .813 |
 49ers - x | 11 | 4 | 0 | .733 |
 Rams - x | 11 | 4 | 0 | .733 |
 Cardinals - e | 3 | 13 | 0 | .188 |
Panthers
Buccaneers
