The San Francisco 49ers are 5-5 against the spread as underdogs against the AFC on the road since 2017.
| TEAM | DATE | ATS | TM | OPP | RESULT | SPREAD | ATS DIFF | O/U | O/U DIFF | TD | 1DWN | OFF | OPP OFF | 3DWN% | 4DWN% | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | 49ers | 10/8/2017 | 0-1 |  SF | +105 | @ |  IND | -125 | L 23-26 | +1.5 | -1.5 (N) | 44 | +5 (O) | 2 | 23 | 402 | 447 | 28.6 | 100.0 |
| 2 | | 49ers | 12/10/2017 | 1-0 | SF | +108 | @ |  HOU | -118 | W 26-16 | -1.5 | +8.5 (Y) | 45.5 | -3.5 (U) | 2 | 20 | 416 | 311 | 18.2 | |
| 3 | | 49ers | 9/23/2018 | 0-1 | SF | +225 | @ |  KC | -245 | L 27-38 | +5.5 | -5.5 (N) | 53.5 | +11.5 (O) | 3 | 26 | 406 | 384 | 22.2 | 100.0 |
| 4 | | 49ers | 9/30/2018 | 1-0 | SF | +370 | @ |  LAC | -415 | L 27-29 | +9.5 | +7.5 (Y) | 46.5 | +9.5 (O) | 3 | 22 | 364 | 368 | 41.7 | |
| 5 | | 49ers | 9/15/2019 | 1-0 | SF | -110 | @ |  CIN | -110 | W 41-17 | +1 | +25 (Y) | 46.5 | +11.5 (O) | 5 | 27 | 571 | 316 | 55.6 | |
| 6 | | 49ers | 12/1/2019 | 1-0 | SF | +204 | @ |  BAL | -250 | L 17-20 | +5.5 | +2.5 (Y) | 45 | -8 (U) | 2 | 15 | 331 | 283 | 33.3 | 50.0 |
| 7 | | 49ers | 2/2/2020 | 0-1 | SF | +104 | @ | KC | -125 | L 20-31 | +1.5 | -9.5 (N) | 53 | -2 (U) | 2 | 21 | 351 | 397 | 37.5 | 0.0 |
| 8 | | 49ers | 10/25/2020 | 1-0 | SF | +131 | @ |  NE | -155 | W 33-6 | +3 | +30 (Y) | 44.5 | -5.5 (U) | 4 | 26 | 467 | 241 | 55.6 | |
| 9 | | 49ers | 12/1/2024 | 0-1 | SF | +265 | @ |  BUF | -330 | L 10-35 | +6.5 | -18.5 (N) | 45.5 | -0.5 (U) | 1 | 15 | 239 | 372 | 30.0 | 100.0 |
| 10 | | 49ers | 10/26/2025 | 0-1 | SF | +135 | @ | HOU | -159 | L 15-26 | +3 | -8 (N) | 42 | -1 (U) | 2 | 12 | 223 | 475 | 33.3 | 0.0 |
| Average | 5.0 | 2.6 | 20.7 | 377.0 | 359.4 | 35.0 | 11.1 | |||||||||||||
| Total | 5-5 | 26 | 207 | 3,770 | 3,594 | 35.0 | 66.7 |
StatMuse has team, game-level data for spread records going back to the 1979 season.
More 49ers Stats
Team Rankings
PPG
20.0
26th
OPP PPG
20.5
8th
RUSH YDS/G
89.4
30th
PASS YDS/G
272.9
2nd
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