The San Francisco 49ers have a 6-8 record against the Bills all-time.

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Regular season

	TEAM	DATE	REC	TM		OPP	RESULT	W%	TD	1DWN	OFF	OPP OFF	3DWN%	4DWN%
1	49ers	9/24/1972	0-1	SF	@	BUF	L 20-27	.000	2	10	202	233
2	49ers	12/21/1980	0-1	SF	vs	BUF	L 13-18	.000	2	19	298	267
3	49ers	12/11/1983	1-0	SF	@	BUF	W 23-10	1.000	2	19	310	303
4	49ers	12/17/1989	1-0	SF	vs	BUF	W 21-10	1.000	3	18	283	301
5	49ers	9/13/1992	0-1	SF	vs	BUF	L 31-34	.000	4	26	598	488	61.5	100.0
6	49ers	12/3/1995	1-0	SF	vs	BUF	W 27-17	1.000	3	18	323	275	31.3	50.0
7	49ers	10/4/1998	0-1	SF	@	BUF	L 21-26	.000	3	23	377	352	46.2
8	49ers	12/2/2001	1-0	SF	vs	BUF	W 35-0	1.000	5	26	409	191	66.7	0.0
9	49ers	12/26/2004	0-1	SF	vs	BUF	L 7-41	.000	1	12	189	441	30.0	100.0
10	49ers	11/30/2008	1-0	SF	@	BUF	W 10-3	1.000	1	12	195	350	46.7
11	49ers	10/7/2012	1-0	SF	vs	BUF	W 45-3	1.000	6	29	621	204	63.6	100.0
12	49ers	10/16/2016	0-1	SF	@	BUF	L 16-45	.000	1	16	300	492	23.1	0.0
13	49ers	12/7/2020	0-1	SF	vs	BUF	L 24-34	.000	3	24	402	449	54.5	0.0
14	49ers	12/1/2024	0-1	SF	@	BUF	L 10-35	.000	1	15	239	372	30.0	100.0
	Average							.429	2.6	19.1	339.0	337.0
	Total		6-8					.429	37	267	4,746	4,718

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More 49ers Stats

Team Leaders

PASS

492

Purdy

RUSH

91

McCaffrey

REC

103

Evans

Team Rankings

PPG

31.0

4th

OPP PPG

10.0

3rd

RUSH YDS/G

134.5

8th

PASS YDS/G

246.0

10th

2026 Division Standings

TEAM	W	L	PCT
49ers	2	0	1.000
Seahawks	2	0	1.000
Cardinals	1	1	.500
Rams	1	1	.500

Schedule

DATE	MATCHUP			TIME (ET)
Sun 9/27	ARI	@	SF	4:05 PM
Sun 10/4	DEN	@	SF	4:25 PM
Sun 10/11	SF	@	SEA	4:25 PM
Mon 10/19	WAS	@	SF	8:15 PM
Sun 10/25	SF	@	ATL	1:00 PM

Last Game

Dolphins

0 - 2

Final

49ers

2 - 0

Sun 20 Sep 2026

NFL 2026 Leaders

Pass Yards Leaders

662

Shough

648

Young

627

Stroud

Rush Yards Leaders

290

Walker

212

Henry

208

Gibbs

Rec Yards Leaders

277

Smith-Njigba

268

Olave

225

Kincaid

Pass TD Leaders

6

Young

6

Prescott

6

Goff

Rush TD Leaders

4

Taylor

4

Allen

4

Henry

Rec TD Leaders

4

Smith-Njigba

4

St. Brown

3

Watson

QB Rating Leaders

127.3

Lock

125.9

Dart

125.8

Allen

Sack Leaders

4.0

Rousseau

3.5

Watt

3.0

Hutchinson

NFL 2026 Rankings

PPG Rankings

38.5

35.5

32.0

31.0

Opp PPG Rankings

8.0

8.5

10.0

12.5

13.5

15.0

Total Yards Rankings

457.5

427.5

424.5

409.0

385.5

Rush Yards Rankings

212.5

186.0

157.0

155.0

144.5

142.5

Pass Yards Rankings

331.0

324.0

313.5

291.0

283.0

279.5

Sack Leaders

8.0

7.0

NFL Fantasy 2026

Fantasy RB Rankings

49

Henry

48.9

Walker

47.3

Taylor

Fantasy WR Rankings

51.7

Smith-Njigba

44.9

St. Brown

37.7

Lamb

Fantasy TE Rankings

28.5

Kincaid

25.6

McBride

23.2

Kelce

Fantasy K Rankings

31

McPherson

27

McLaughlin

24

Butker

NFL 2026 Betting

Best Record ATS

2-0

Worst Record ATS

0-2

NFL 2026 Standings

NFC East	W	L	T	PCT
Eagles	2	0	0	1.000
Giants	1	1	0	.500
Cowboys	1	1	0	.500
Commanders	0	2	0	.000
NFC North	W	L	T	PCT
Vikings	2	0	0	1.000
Lions	1	1	0	.500
Bears	1	1	0	.500
Packers	1	1	0	.500
NFC South	W	L	T	PCT
Panthers	1	1	0	.500
Saints	1	1	0	.500
Buccaneers	0	2	0	.000
Falcons	0	2	0	.000
NFC West	W	L	T	PCT
Seahawks	2	0	0	1.000
49ers	2	0	0	1.000
Rams	1	1	0	.500
Cardinals	1	1	0	.500

AFC East	W	L	T	PCT
Bills	2	0	0	1.000
Patriots	1	1	0	.500
Jets	1	1	0	.500
Dolphins	0	2	0	.000
AFC North	W	L	T	PCT
Bengals	2	0	0	1.000
Ravens	1	1	0	.500
Steelers	1	1	0	.500
Browns	1	1	0	.500
AFC South	W	L	T	PCT
Jaguars	1	1	0	.500
Titans	0	2	0	.000
Texans	0	2	0	.000
Colts	0	2	0	.000
AFC West	W	L	T	PCT
Chiefs	2	0	0	1.000
Raiders	2	0	0	1.000
Broncos	1	1	0	.500
Chargers	0	2	0	.000