Barry Sanders had the most games with 150+ rushing yards, with 25 games.

who has the most career 150 rushing yard games
Interpreted as:
Who has the most career 150 or more rushing yard regular-season games?
SandersPaytonPetersonSmithDickersonTomlinsonSimpsonCampbellBrownHenryGreenDavisFaulkAlexanderHolmesMcCoyLewisDorsettCharlesJohnsonJohnsonTaylor2520191818161614141212121211111010109999
NAMEGPRUSH YDSATTYPCRUSH YDS/GRUSH TDREC YDSRECTRGAVGREC YDS/GREC TD
Barry SandersBarry Sanders254,4646147.3178.633312456.912.51
Walter PaytonWalter Payton203,5465766.2177.327287387.614.40
Adrian PetersonAdrian Peterson193,5645136.9187.62522936556.412.11
Emmitt SmithEmmitt Smith183,0014856.2166.7272745505.015.21
Eric DickersonEric Dickerson183,2155266.1178.6272542410.614.10
LaDainian TomlinsonLaDainian Tomlinson163,0294307.0189.334404731005.525.32
O.J. SimpsonO.J. Simpson163,1064357.1194.121138159.28.60
Earl CampbellEarl Campbell142,5764685.5184.0212883.52.00
Jim BrownJim Brown142,5443427.4181.7213092611.922.13
Derrick HenryDerrick Henry122,3793337.1198.32816919248.914.10
Ahman GreenAhman Green122,0082717.4167.31123637496.419.72
Terrell DavisTerrell Davis122,2023506.3183.517223278.318.62
Marshall FaulkMarshall Faulk122,2042907.6183.71858162649.448.45
Shaun AlexanderShaun Alexander111,9883216.2180.718519155.74.61
Priest HolmesPriest Holmes111,9022926.5172.91737540449.434.14
LeSean McCoyLeSean McCoy101,6682566.5166.8117616194.87.60
Jamal LewisJamal Lewis101,9562787.0195.61212414198.912.40
Tony DorsettTony Dorsett101,6542227.5165.4994137.29.40
Jamaal CharlesJamaal Charles91,6962068.2188.41016920308.518.81
Chris JohnsonChris Johnson91,5861928.3176.21216422317.518.21
Larry JohnsonLarry Johnson91,5662825.6174.0187613225.88.41
Fred TaylorFred Taylor91,5882476.4176.41511919246.313.21
Corey DillonCorey Dillon91,7572606.8195.2149416225.910.41
Curtis MartinCurtis Martin91,5722705.8174.7820727257.723.01
Arian FosterArian Foster81,3492166.2168.61210118285.612.61
StatMuse has game-level data for rushing yards going back to the 1960 season.