The San Francisco 49ers have a 27-12-1 record against the Rams between October 4, 2005 and October 4, 2025.
| TEAM | DATE | REC | TM | OPP | RESULT | W% | TD | 1DWN | OFF | OPP OFF | 3DWN% | 4DWN% | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | 49ers | 12/24/2005 | 1-0 |  SF | @ |  STL | W 24-20 | 1.000 | 3 | 15 | 321 | 389 | 25.0 | |
| 2 | | 49ers | 9/17/2006 | 1-0 | SF | vs | STL | W 20-13 | 1.000 | 2 | 14 | 360 | 265 | 33.3 | |
| 3 | | 49ers | 11/26/2006 | 0-1 | SF | @ | STL | L 17-20 | .000 | 2 | 20 | 319 | 349 | 45.5 | |
| 4 | | 49ers | 9/16/2007 | 1-0 | SF | @ | STL | W 17-16 | 1.000 | 2 | 8 | 186 | 392 | 23.1 | 100.0 |
| 5 | | 49ers | 11/18/2007 | 0-1 | SF | vs | STL | L 9-13 | .000 | 0 | 13 | 244 | 207 | 21.4 | |
| 6 | | 49ers | 11/16/2008 | 1-0 | SF | vs | STL | W 35-16 | 1.000 | 5 | 19 | 334 | 406 | 45.5 | |
| 7 | | 49ers | 12/21/2008 | 1-0 | SF | @ | STL | W 17-16 | 1.000 | 2 | 15 | 273 | 343 | 36.4 | 100.0 |
| 8 | | 49ers | 10/4/2009 | 1-0 | SF | vs | STL | W 35-0 | 1.000 | 5 | 13 | 228 | 177 | 30.8 | |
| 9 | | 49ers | 1/3/2010 | 1-0 | SF | @ | STL | W 28-6 | 1.000 | 4 | 16 | 329 | 109 | 26.7 | 0.0 |
| 10 | | 49ers | 11/14/2010 | 1-0 | SF | vs | STL | W 23-20 | 1.000 | 2 | 19 | 421 | 332 | 0.0 | 100.0 |
| 11 | | 49ers | 12/26/2010 | 0-1 | SF | @ | STL | L 17-25 | .000 | 2 | 12 | 331 | 335 | 25.0 | 100.0 |
| 12 | | 49ers | 12/4/2011 | 1-0 | SF | vs | STL | W 26-0 | 1.000 | 2 | 18 | 389 | 157 | 28.6 | |
| 13 | | 49ers | 1/1/2012 | 1-0 | SF | @ | STL | W 34-27 | 1.000 | 4 | 21 | 321 | 311 | 37.5 | 100.0 |
| 14 | | 49ers | 11/11/2012 | 0-0-1 | SF | vs | STL | T 24-24 | .500 | 3 | 25 | 341 | 458 | 18.2 | 100.0 |
| 15 | | 49ers | 12/2/2012 | 0-1 | SF | @ | STL | L 13-16 | .000 | 1 | 18 | 339 | 293 | 42.1 | 0.0 |
| 16 | | 49ers | 9/26/2013 | 1-0 | SF | @ | STL | W 35-11 | 1.000 | 5 | 19 | 370 | 188 | 40.0 | 100.0 |
| 17 | | 49ers | 12/1/2013 | 1-0 | SF | vs | STL | W 23-13 | 1.000 | 2 | 20 | 338 | 312 | 33.3 | |
| 18 | | 49ers | 10/13/2014 | 1-0 | SF | @ | STL | W 31-17 | 1.000 | 4 | 17 | 432 | 309 | 42.9 | 0.0 |
| 19 | | 49ers | 11/2/2014 | 0-1 | SF | vs | STL | L 10-13 | .000 | 1 | 20 | 263 | 193 | 25.0 | |
| 20 | | 49ers | 11/1/2015 | 0-1 | SF | @ | STL | L 6-27 | .000 | 0 | 11 | 189 | 388 | 17.6 | 0.0 |
| 21 | | 49ers | 1/3/2016 | 1-0 | SF | vs | STL | W 19-16 | 1.000 | 1 | 21 | 458 | 364 | 44.4 | 0.0 |
| 22 | | 49ers | 9/12/2016 | 1-0 | SF | vs | LA | W 28-0 | 1.000 | 4 | 28 | 320 | 185 | 47.1 | 50.0 |
| 23 | | 49ers | 12/24/2016 | 1-0 | SF | @ | LA | W 22-21 | 1.000 | 3 | 21 | 323 | 177 | 37.5 | 100.0 |
| 24 | | 49ers | 9/21/2017 | 0-1 | SF | vs |  LAR | L 39-41 | .000 | 5 | 25 | 421 | 418 | 50.0 | 66.7 |
| 25 | | 49ers | 12/31/2017 | 1-0 | SF | @ | LAR | W 34-13 | 1.000 | 4 | 25 | 461 | 251 | 50.0 | |
| Average | .688 | 2.7 | 18.9 | 337.4 | 297.9 | 36.3 | 2.7 | ||||||||
| Total | 27-12-1 | .688 | 109 | 756 | 13,497 | 11,916 | 36.3 | 66.7 | |||||||
More 49ers Stats
Team Rankings
PPG
21.2
21st
OPP PPG
19.6
8th
RUSH YDS/G
85.2
29th
PASS YDS/G
298.2
2nd
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| NFC East | W | L | T | PCT |
|---|---|---|---|---|
 Eagles | 4 | 0 | 0 | 1.000 |
 Commanders | 2 | 2 | 0 | .500 |
| NFC North | W | L | T | PCT |
 Lions | 3 | 1 | 0 | .750 |
 Packers | 2 | 1 | 1 | .625 |
| NFC South | W | L | T | PCT |
 Buccaneers | 3 | 1 | 0 | .750 |
 Falcons | 2 | 2 | 0 | .500 |
| NFC West | W | L | T | PCT |
| 49ers | 4 | 1 | 0 | .800 |
 Seahawks | 3 | 1 | 0 | .750 |
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