The San Francisco 49ers had their lowest point differential in a game against the Rams on November 9, 1958, with a -49-point differential.
Interpreted as:
49ers worst loss in a regular-season game ever| TEAM | DIFF | DATE | TM | OPP | RESULT | TD | 1DWN | OFF | OPP OFF | 3DWN% | 4DWN% | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | 49ers | -49 | 11/9/1958 |  SF | @ |  LA | L 7-56 | 1 | 20 | 282 | 577 | ||
| 2 | | 49ers | -45 | 10/12/1980 | SF | @ |  DAL | L 14-59 | 2 | 14 | 225 | 460 | ||
| 3 | | 49ers | -42 | 10/29/1967 | SF | vs |  DET | L 3-45 | 0 | 10 | 173 | 391 | ||
| 4 | | 49ers | -41 | 10/1/2006 | SF | @ |  KC | L 0-41 | 0 | 10 | 165 | 333 | 23.1 | |
| 5 | | 49ers | -41 | 12/12/1965 | SF | @ |  CHI | L 20-61 | 3 | 19 | 330 | 584 | ||
| 6 | | 49ers | -41 | 11/14/1954 | SF | @ | DET | L 7-48 | 1 | 16 | 349 | 474 | ||
| 7 | | 49ers | -40 | 9/27/2015 | SF | @ |  ARI | L 7-47 | 1 | 10 | 156 | 446 | 33.3 | |
| 8 | | 49ers | -39 | 9/18/2005 | SF | @ |  PHI | L 3-42 | 0 | 8 | 142 | 583 | 25.0 | |
| 9 | | 49ers | -38 | 12/11/2005 | SF | @ |  SEA | L 3-41 | 0 | 8 | 113 | 438 | 16.7 | |
| 10 | | 49ers | -38 | 11/30/2003 | SF | @ |  BAL | L 6-44 | 0 | 10 | 264 | 282 | 26.7 | 0.0 |
| 11 | | 49ers | -38 | 9/12/1999 | SF | @ |  JAX | L 3-41 | 0 | 11 | 203 | 344 | 7.1 | 50.0 |
| 12 | | 49ers | -38 | 11/3/1963 | SF | vs | DET | L 7-45 | 1 | 9 | 133 | 509 | ||
| 13 | | 49ers | -35 | 10/11/2009 | SF | vs |  ATL | L 10-45 | 1 | 13 | 279 | 477 | 28.6 | 50.0 |
| 14 | | 49ers | -35 | 10/23/2005 | SF | @ |  WAS | L 17-52 | 2 | 9 | 194 | 457 | 25.0 | |
| 15 | | 49ers | -35 | 11/30/1997 | SF | @ | KC | L 9-44 | 0 | 13 | 279 | 340 | 12.5 | 0.0 |
| 16 | | 49ers | -35 | 10/2/1955 | SF | vs |  CLE | L 3-38 | 0 | 8 | 139 | 357 | ||
| 17 | | 49ers | -34 | 12/26/2004 | SF | vs |  BUF | L 7-41 | 1 | 12 | 189 | 441 | 30.0 | 100.0 |
| 18 | | 49ers | -34 | 9/26/2004 | SF | @ | SEA | L 0-34 | 0 | 9 | 175 | 374 | 15.4 | 100.0 |
| 19 | | 49ers | -34 | 10/1/1967 | SF | @ |  BAL | L 7-41 | 1 | 15 | 240 | 524 | ||
| 20 | | 49ers | -34 | 11/17/1963 | SF | @ |  NYG | L 14-48 | 2 | 10 | 224 | 568 | ||
| 21 | | 49ers | -32 | 11/21/2004 | SF | @ |  TB | L 3-35 | 0 | 13 | 197 | 352 | 8.3 | 100.0 |
| 22 | | 49ers | -32 | 10/2/1994 | SF | vs | PHI | L 8-40 | 1 | 11 | 189 | 437 | 33.3 | 66.7 |
| 23 | | 49ers | -31 | 10/29/2006 | SF | @ | CHI | L 10-41 | 1 | 12 | 248 | 402 | 30.0 | 0.0 |
| 24 | | 49ers | -31 | 9/30/1966 | SF | @ | LA | L 3-34 | 0 | 15 | 251 | 356 | ||
| 25 | | 49ers | -31 | 9/29/1963 | SF | @ |  MIN | L 14-45 | 2 | 14 | 237 | 396 | ||
More 49ers Stats
Team Rankings
PPG
19.7
23rd
OPP PPG
16.3
3rd
RUSH YDS/G
89.7
26th
PASS YDS/G
280.0
3rd
HOU 
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NFL 2025 Division Standings
| NFC East | W | L | T | PCT |
|---|---|---|---|---|
| Eagles | 3 | 0 | 0 | 1.000 |
 Commanders | 2 | 1 | 0 | .667 |
| NFC North | W | L | T | PCT |
 Packers | 2 | 1 | 0 | .667 |
| Vikings | 2 | 1 | 0 | .667 |
| NFC South | W | L | T | PCT |
| Buccaneers | 3 | 0 | 0 | 1.000 |
 Panthers | 1 | 2 | 0 | .333 |
| NFC West | W | L | T | PCT |
| 49ers | 3 | 0 | 0 | 1.000 |
 Rams | 2 | 1 | 0 | .667 |
Patriots 
Bengals 
Steelers 
Colts 
Chargers 
Raiders 
NYJ 
NO 
TEN 
