Since 2000, the San Francisco 49ers have their lowest point differential in a game against the Chiefs on October 1, 2006, with a -41-point differential.
Interpreted as:
49ers worst loss in a regular-season game since 2000| TEAM | DIFF | DATE | TM | OPP | RESULT | TD | 1DWN | OFF | OPP OFF | 3DWN% | 4DWN% | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | 49ers | -41 | 10/1/2006 | @ | L 0-41 | 0 | 10 | 165 | 333 | 23.1 | |||
| 2 | | 49ers | -40 | 9/27/2015 | @ | L 7-47 | 1 | 10 | 156 | 446 | 33.3 | |||
| 3 | | 49ers | -39 | 9/18/2005 | @ | L 3-42 | 0 | 8 | 142 | 583 | 25.0 | |||
| 4 | | 49ers | -38 | 12/11/2005 | @ | L 3-41 | 0 | 8 | 113 | 438 | 16.7 | |||
| 5 | | 49ers | -38 | 11/30/2003 | @ | L 6-44 | 0 | 10 | 264 | 282 | 26.7 | 0.0 | ||
| 6 | | 49ers | -35 | 10/11/2009 | vs | L 10-45 | 1 | 13 | 279 | 477 | 28.6 | 50.0 | ||
| 7 | | 49ers | -35 | 10/23/2005 | @ | L 17-52 | 2 | 9 | 194 | 457 | 25.0 | |||
| 8 | | 49ers | -34 | 12/26/2004 | vs | L 7-41 | 1 | 12 | 189 | 441 | 30.0 | 100.0 | ||
| 9 | | 49ers | -34 | 9/26/2004 | @ | L 0-34 | 0 | 9 | 175 | 374 | 15.4 | 100.0 | ||
| 10 | | 49ers | -32 | 11/21/2004 | @ | L 3-35 | 0 | 13 | 197 | 352 | 8.3 | 100.0 | ||
| 11 | | 49ers | -31 | 10/29/2006 | @ | L 10-41 | 1 | 12 | 248 | 402 | 30.0 | 0.0 | ||
| 12 | | 49ers | -30 | 10/22/2017 | vs | L 10-40 | 1 | 23 | 290 | 501 | 46.2 | 0.0 | ||
| 13 | | 49ers | -29 | 10/21/2018 | vs | L 10-39 | 1 | 16 | 228 | 339 | 27.3 | 0.0 | ||
| 14 | | 49ers | -29 | 10/16/2016 | @ | L 16-45 | 1 | 16 | 300 | 492 | 23.1 | 0.0 | ||
| 15 | | 49ers | -29 | 12/23/2012 | @ | L 13-42 | 1 | 17 | 313 | 346 | 27.3 | 100.0 | ||
| 16 | | 49ers | -29 | 10/15/2006 | vs | L 19-48 | 2 | 15 | 274 | 421 | 36.4 | 0.0 | ||
| 17 | | 49ers | -29 | 12/23/2000 | @ | L 9-38 | 1 | 16 | 192 | 362 | 28.6 | 66.7 | ||
| 18 | | 49ers | -28 | 11/24/2024 | @ | L 10-38 | 1 | 11 | 241 | 325 | 30.0 | 0.0 | ||
| 19 | | 49ers | -28 | 12/18/2016 | @ | L 13-41 | 2 | 15 | 272 | 550 | 46.2 | |||
| 20 | | 49ers | -28 | 9/28/2003 | @ | L 7-35 | 1 | 18 | 372 | 354 | 40.0 | 25.0 | ||
| 21 | | 49ers | -27 | 12/2/2018 | @ | L 16-43 | 2 | 24 | 452 | 331 | 43.8 | 50.0 | ||
| 22 | | 49ers | -27 | 12/16/2010 | @ | L 7-34 | 1 | 11 | 192 | 374 | 16.7 | 0.0 | ||
| 23 | | 49ers | -26 | 10/11/2020 | vs | L 17-43 | 2 | 19 | 259 | 436 | 20.0 | 0.0 | ||
| 24 | | 49ers | -26 | 9/15/2013 | @ | L 3-29 | 0 | 12 | 207 | 290 | 25.0 | 0.0 | ||
| 25 | | 49ers | -25 | 12/1/2024 | @ | L 10-35 | 1 | 15 | 239 | 372 | 30.0 | 100.0 | ||
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More 49ers Stats
Team Leaders 
PASS
2,167
Purdy
RUSH
1,202
McCaffrey
REC
924
McCaffrey
Team Rankings
PPG
25.7
10th
OPP PPG
21.8
13th
RUSH YDS/G
106.9
24th
PASS YDS/G
254.0
6th
NFL 2025 Leaders
NFL 2025 Rankings
NFL Fantasy 2025
NFL 2025 Betting
NFL 2025 Standings
| AFC East | W | L | T | PCT |
|---|---|---|---|---|
 Patriots - y | 14 | 3 | 0 | .824 |
 Bills - w | 12 | 5 | 0 | .706 |
 Dolphins - e | 7 | 10 | 0 | .412 |
 Jets - e | 3 | 14 | 0 | .176 |
| AFC North | W | L | T | PCT |
 Steelers - y | 10 | 7 | 0 | .588 |
 Ravens - e | 8 | 9 | 0 | .471 |
 Bengals - e | 6 | 11 | 0 | .353 |
 Browns - e | 5 | 12 | 0 | .294 |
| AFC South | W | L | T | PCT |
 Jaguars - y | 13 | 4 | 0 | .765 |
 Texans - w | 12 | 5 | 0 | .706 |
 Colts - e | 8 | 9 | 0 | .471 |
 Titans - e | 3 | 14 | 0 | .176 |
| AFC West | W | L | T | PCT |
 Broncos - z* | 14 | 3 | 0 | .824 |
 Chargers - w | 11 | 6 | 0 | .647 |
 Chiefs - e | 6 | 11 | 0 | .353 |
 Raiders - e | 3 | 14 | 0 | .176 |
| NFC East | W | L | T | PCT |
|---|---|---|---|---|
 Eagles - y | 11 | 6 | 0 | .647 |
 Cowboys - e | 7 | 9 | 1 | .441 |
 Commanders - e | 5 | 12 | 0 | .294 |
 Giants - e | 4 | 13 | 0 | .235 |
| NFC North | W | L | T | PCT |
 Bears - y | 11 | 6 | 0 | .647 |
 Packers - w | 9 | 7 | 1 | .559 |
 Vikings - e | 9 | 8 | 0 | .529 |
 Lions - e | 9 | 8 | 0 | .529 |
| NFC South | W | L | T | PCT |
 Panthers - y | 8 | 9 | 0 | .471 |
 Buccaneers - e | 8 | 9 | 0 | .471 |
 Falcons - e | 8 | 9 | 0 | .471 |
 Saints - e | 6 | 11 | 0 | .353 |
| NFC West | W | L | T | PCT |
 Seahawks - z* | 14 | 3 | 0 | .824 |
 Rams - w | 12 | 5 | 0 | .706 |
 49ers - w | 12 | 5 | 0 | .706 |
 Cardinals - e | 3 | 14 | 0 | .176 |