From 2018 through 2026, the Buffalo Bills have the highest point differential by a team in a Week-4 game, with a 40-point differential against the Texans on October 3, 2021.
| TEAM | DIFF | DATE | TM | OPP | RESULT | TD | 1DWN | OFF | OPP OFF | 3DWN% | 4DWN% | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | Bills | 40 | 10/3/2021 | vs | W 40-0 | 4 | 26 | 450 | 109 | 41.7 | 50.0 | ||
| 2 |  | Bears | 38 | 9/30/2018 | vs | W 48-10 | 6 | 28 | 483 | 311 | 50.0 | |||
| 3 |  | Cowboys | 35 | 10/1/2023 | vs | W 38-3 | 4 | 22 | 377 | 253 | 53.3 | 0.0 | ||
| 4 |  | Patriots | 31 | 9/30/2018 | vs | W 38-7 | 5 | 26 | 449 | 172 | 66.7 | |||
| 5 | | Patriots | 29 | 9/28/2025 | vs | W 42-13 | 6 | 16 | 307 | 326 | 33.3 | 100.0 | ||
| 6 |  | Commanders | 28 | 9/29/2024 | @ | W 42-14 | 5 | 29 | 449 | 296 | 75.0 | 100.0 | ||
| 7 | | Bills | 28 | 10/1/2023 | vs | W 48-20 | 6 | 24 | 414 | 393 | 50.0 | |||
| 8 |  | Texans | 26 | 9/28/2025 | vs | W 26-0 | 3 | 20 | 353 | 175 | 40.0 | 100.0 | ||
| 9 |  | Broncos | 25 | 9/29/2025 | vs | W 28-3 | 4 | 29 | 512 | 159 | 57.1 | 0.0 | ||
| 10 |  | Ravens | 25 | 9/29/2024 | vs | W 35-10 | 5 | 22 | 427 | 236 | 55.6 | |||
| 11 | | Ravens | 25 | 10/1/2023 | @ | W 28-3 | 4 | 16 | 296 | 166 | 33.3 | 100.0 | ||
| 12 |  | Lions | 24 | 9/28/2025 | vs | W 34-10 | 4 | 16 | 277 | 249 | 42.9 | 0.0 | ||
| 13 |  | Titans | 24 | 10/1/2023 | vs | W 27-3 | 3 | 23 | 400 | 211 | 61.5 | 100.0 | ||
| 14 | | Texans | 24 | 10/1/2023 | vs | W 30-6 | 3 | 24 | 451 | 225 | 50.0 | 0.0 | ||
| 15 |  | Steelers | 24 | 9/30/2019 | vs | W 27-3 | 3 | 20 | 326 | 175 | 33.3 | 0.0 | ||
| 16 |  | Packers | 22 | 9/30/2018 | vs | W 22-0 | 2 | 22 | 423 | 145 | 57.9 | 0.0 | ||
| 17 |  | Seahawks | 21 | 10/2/2023 | @ | W 24-3 | 3 | 13 | 281 | 248 | 25.0 | 0.0 | ||
| 18 |  | Giants | 21 | 9/29/2019 | vs | W 24-3 | 3 | 24 | 389 | 176 | 61.5 | 100.0 | ||
| 19 |  | Chargers | 20 | 9/29/2019 | @ | W 30-10 | 3 | 24 | 390 | 233 | 61.5 | 0.0 | ||
| 20 | | Titans | 19 | 9/30/2024 | @ | W 31-12 | 2 | 16 | 244 | 184 | 16.7 | 100.0 | ||
| 21 |  | 49ers | 19 | 10/1/2023 | vs | W 35-16 | 5 | 30 | 395 | 362 | 60.0 | 100.0 | ||
| 22 |  | Jaguars | 19 | 9/30/2018 | vs | W 31-12 | 3 | 23 | 503 | 178 | 40.0 | 100.0 | ||
| 23 |  | Chiefs | 17 | 9/28/2025 | vs | W 37-20 | 4 | 24 | 382 | 360 | 33.3 | 100.0 | ||
| 24 |  | Buccaneers | 17 | 9/29/2024 | vs | W 33-16 | 4 | 29 | 445 | 227 | 46.2 | 100.0 | ||
| 25 | | 49ers | 17 | 9/29/2024 | vs | W 30-13 | 3 | 19 | 431 | 216 | 53.8 | |||
BUF
HOU
CHI
TB
DAL
NE
MIA
CAR
WAS
ARI
TEN
DEN
CIN
BAL
CLE
DET
PIT
GB
SEA
NYG
WAS
LAC
SF
JAX
NYJ
KC
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More Bills Stats
Team Leaders 
PASS
582
Allen
RUSH
192
Cook
REC
225
Kincaid
Team Rankings
PPG
38.5
4th
OPP PPG
31.0
22nd
RUSH YDS/G
144.5
7th
PASS YDS/G
291.0
5th
Jets
LAR
LV
NFL 2026 Leaders
NFL 2026 Rankings
NFL Fantasy 2026
NFL 2026 Betting
NFL 2026 Standings
| NFC East | W | L | T | PCT |
|---|---|---|---|---|
1 | 0 | 0 | 1.000 | |
1 | 0 | 0 | 1.000 | |
0 | 1 | 0 | .000 | |
0 | 1 | 0 | .000 | |
| NFC North | W | L | T | PCT |
1 | 0 | 0 | 1.000 | |
1 | 0 | 0 | 1.000 | |
1 | 1 | 0 | .500 | |
0 | 1 | 0 | .000 | |
| NFC South | W | L | T | PCT |
0 | 1 | 0 | .000 | |
0 | 1 | 0 | .000 | |
0 | 1 | 0 | .000 | |
0 | 1 | 0 | .000 | |
| NFC West | W | L | T | PCT |
1 | 0 | 0 | 1.000 | |
1 | 0 | 0 | 1.000 | |
1 | 0 | 0 | 1.000 | |
0 | 1 | 0 | .000 |
Vikings
Bears
Falcons
Saints| AFC East | W | L | T | PCT |
|---|---|---|---|---|
2 | 0 | 0 | 1.000 | |
1 | 0 | 0 | 1.000 | |
0 | 1 | 0 | .000 | |
0 | 1 | 0 | .000 | |
| AFC North | W | L | T | PCT |
1 | 0 | 0 | 1.000 | |
1 | 0 | 0 | 1.000 | |
1 | 0 | 0 | 1.000 | |
0 | 1 | 0 | .000 | |
| AFC South | W | L | T | PCT |
1 | 0 | 0 | 1.000 | |
0 | 1 | 0 | .000 | |
0 | 1 | 0 | .000 | |
0 | 1 | 0 | .000 | |
| AFC West | W | L | T | PCT |
1 | 0 | 0 | 1.000 | |
1 | 0 | 0 | 1.000 | |
0 | 1 | 0 | .000 | |
0 | 1 | 0 | .000 |
Colts