The San Francisco 49ers had the highest point differential by a team in a game in 2001, with a 38-point differential against the Saints on January 6, 2002.

Interpreted as:

biggest win margin in a regular-season game 2001

	TEAM	DIFF	DATE	TM		OPP	RESULT	TD	1DWN	OFF	OPP OFF	3DWN%	4DWN%
1	49ers	38	1/6/2002	SF	@	NO	W 38-0	5	22	407	126	35.7	50.0
2	Packers	37	9/24/2001	GB	vs	WAS	W 37-0	4	23	386	137	40.0	100.0
3	Dolphins	35	12/10/2001	MIA	vs	IND	W 41-6	6	24	366	254	64.3	100.0
4	49ers	35	12/2/2001	SF	vs	BUF	W 35-0	5	26	409	191	66.7	0.0
5	Rams	35	10/8/2001	STL	@	DET	W 35-0	5	23	378	334	54.5	0.0
6	Rams	34	11/11/2001	STL	vs	CAR	W 48-14	6	20	493	146	50.0	100.0
7	Steelers	33	12/23/2001	PIT	vs	DET	W 47-14	6	25	429	151	57.1	100.0
8	Eagles	33	11/18/2001	PHI	@	DAL	W 36-3	3	17	227	213	41.2	100.0
9	Patriots	32	1/6/2002	NE	@	CAR	W 38-6	5	16	298	322	40.0	50.0
10	Rams	32	9/30/2001	STL	vs	MIA	W 42-10	6	27	441	253	63.6	100.0
11	Chiefs	32	9/30/2001	KC	@	WAS	W 45-13	6	29	546	218	61.5	0.0
12	Eagles	31	11/11/2001	PHI	vs	MIN	W 48-17	6	33	487	301	50.0
13	Patriots	31	9/30/2001	NE	vs	IND	W 44-13	5	19	336	322	46.7	100.0
14	Redskins	30	12/30/2001	WAS	@	NO	W 40-10	4	19	263	213	62.5
15	Jaguars	30	12/23/2001	JAX	@	MIN	W 33-3	3	23	423	214	64.3
16	Rams	29	12/2/2001	STL	@	ATL	W 35-6	5	19	422	320	57.1
17	Bears	28	10/7/2001	CHI	@	ATL	W 31-3	4	15	300	335	36.4
18	Dolphins	27	1/6/2002	MIA	vs	BUF	W 34-7	4	21	289	250	35.7
19	Buccaneers	27	12/23/2001	TB	vs	NO	W 48-21	5	23	364	271	38.5	100.0
20	Steelers	27	10/29/2001	PIT	vs	TEN	W 34-7	4	24	405	214	33.3	100.0
21	Buccaneers	27	10/28/2001	TB	vs	MIN	W 41-14	5	26	446	195	57.1	50.0
22	Chargers	27	9/9/2001	SD	vs	WAS	W 30-3	3	19	255	161	42.9
23	Seahawks	26	12/16/2001	SEA	vs	DAL	W 29-3	3	22	312	218	23.1	50.0
24	Rams	25	12/30/2001	STL	vs	IND	W 42-17	6	27	483	261	80.0
25	Bears	24	12/30/2001	CHI	@	DET	W 24-0	3	15	326	332	28.6

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More 49ers Stats

Team Leaders

PASS

2,167

Purdy

RUSH

1,202

McCaffrey

REC

924

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Team Rankings

PPG

25.7

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OPP PPG

21.8

13th

RUSH YDS/G

106.9

24th

PASS YDS/G

254.0

6th

2025 Division Standings

TEAM	W	L	PCT
Seahawks	14	3	.824
Rams	12	5	.706
49ers	12	5	.706
Cardinals	3	14	.176

Last Game

49ers

1 - 1

Final

Seahawks

1 - 0

Sat 17 Jan 2026

NFL 2025 Leaders

Pass Yards Leaders

4,707

Stafford

4,564

Goff

4,552

Prescott

Rush Yards Leaders

1,621

Cook

1,595

Henry

1,585

Taylor

Rec Yards Leaders

1,793

Smith-Njigba

1,715

Nacua

1,429

Pickens

Pass TD Leaders

46

Stafford

34

Goff

31

Maye

Rush TD Leaders

18

Taylor

16

Henry

14

Allen

Rec TD Leaders

14

Adams

11

McBride

11

St. Brown

QB Rating Leaders

113.5

Maye

109.2

Stafford

105.5

Goff

Sack Leaders

23.0

Garrett

16.5

Burns

15.0

Hunter

NFL 2025 Rankings

PPG Rankings

30.5

28.8

28.4

28.3

27.9

Opp PPG Rankings

17.2

17.4

18.3

18.8

19.1

19.3

Total Yards Rankings

394.6

391.9

379.4

376.3

373.2

369.5

Rush Yards Rankings

159.6

156.6

144.5

134.7

129.1

128.9

Pass Yards Rankings

278.5

276.9

268.6

262.3

256.1

254.0

Sack Leaders

68.0

57.0

53.0

49.0

48.0

NFL Fantasy 2025

Fantasy RB Rankings

316.3

Taylor

314.6

McCaffrey

291.8

Robinson

Fantasy WR Rankings

246

Nacua

240.9

Smith-Njigba

207

St. Brown

Fantasy TE Rankings

189.9

McBride

125.1

Goedert

122.8

Pitts

Fantasy K Rankings

202

Myers

194

Fairbairn

187.6

Aubrey

NFL 2025 Betting

Best Record ATS

15-5

12-6

14-7

12-6-1

12-7

11-7

Worst Record ATS

5-12

5-12-1

6-11

7-10

NFL 2025 Standings

AFC East	W	L	T	PCT
Patriots - y	14	3	0	.824
Bills - w	12	5	0	.706
Dolphins - e	7	10	0	.412
Jets - e	3	14	0	.176
AFC North	W	L	T	PCT
Steelers - y	10	7	0	.588
Ravens - e	8	9	0	.471
Bengals - e	6	11	0	.353
Browns - e	5	12	0	.294
AFC South	W	L	T	PCT
Jaguars - y	13	4	0	.765
Texans - w	12	5	0	.706
Colts - e	8	9	0	.471
Titans - e	3	14	0	.176
AFC West	W	L	T	PCT
Broncos - z*	14	3	0	.824
Chargers - w	11	6	0	.647
Chiefs - e	6	11	0	.353
Raiders - e	3	14	0	.176

NFC East	W	L	T	PCT
Eagles - y	11	6	0	.647
Cowboys - e	7	9	1	.441
Commanders - e	5	12	0	.294
Giants - e	4	13	0	.235
NFC North	W	L	T	PCT
Bears - y	11	6	0	.647
Packers - w	9	7	1	.559
Vikings - e	9	8	0	.529
Lions - e	9	8	0	.529
NFC South	W	L	T	PCT
Panthers - y	8	9	0	.471
Buccaneers - e	8	9	0	.471
Falcons - e	8	9	0	.471
Saints - e	6	11	0	.353
NFC West	W	L	T	PCT
Seahawks - z*	14	3	0	.824
Rams - w	12	5	0	.706
49ers - w	12	5	0	.706
Cardinals - e	3	14	0	.176

The San Francisco 49ers had the highest point differential by a team in a game in 2001, with a 38-point differential against the Saints on January 6, 2002.

Interpreted as:

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246

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