The Buffalo Bills are 35-32-1 against the spread as favorites in the regular season against the AFC since 2018.
| TEAM | DATE | ATS | TM | OPP | RESULT | SPREAD | ATS DIFF | O/U | O/U DIFF | TD | 1DWN | OFF | OPP OFF | 3DWN% | 4DWN% | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | Bills | 12/9/2018 | 0-1 | -205 | vs | +188 | L 23-27 | -4.5 | -8.5 (N) | 37 | +13 (O) | 2 | 24 | 368 | 248 | 50.0 | |||
| 2 | | Bills | 12/30/2018 | 1-0 | -240 | vs | +220 | W 42-17 | -5.5 | +19.5 (Y) | 39.5 | +19.5 (O) | 6 | 23 | 381 | 225 | 45.5 | 50.0 | ||
| 3 | | Bills | 9/22/2019 | 0-1 | -270 | vs | +216 | W 21-17 | -6 | -2 (N) | 43.5 | -5.5 (U) | 2 | 25 | 416 | 306 | 38.5 | |||
| 4 | | Bills | 10/20/2019 | 0-1 | -1336 | vs | +802 | W 31-21 | -17 | -7 (N) | 42 | +10 (O) | 3 | 17 | 305 | 381 | 30.0 | |||
| 5 | | Bills | 11/17/2019 | 1-0 | -352 | @ | +274 | W 37-20 | -7 | +10 (Y) | 41.5 | +15.5 (O) | 4 | 22 | 424 | 303 | 35.7 | 100.0 | ||
| 6 | | Bills | 11/24/2019 | 1-0 | -205 | vs | +169 | W 20-3 | -3.5 | +13.5 (Y) | 37 | -14 (U) | 2 | 22 | 424 | 134 | 50.0 | |||
| 7 | | Bills | 9/13/2020 | 1-0 | -294 | vs | +235 | W 27-17 | -6.5 | +3.5 (Y) | 39.5 | +4.5 (O) | 3 | 31 | 404 | 254 | 50.0 | 100.0 | ||
| 8 | | Bills | 9/20/2020 | 0-1 | -229 | @ | +192 | W 31-28 | -5.5 | -2.5 (N) | 42 | +17 (O) | 4 | 23 | 523 | 410 | 50.0 | |||
| 9 | | Bills | 10/4/2020 | 1-0 | -178 | @ | +148 | W 30-23 | -3.5 | +3.5 (Y) | 52.5 | +0.5 (O) | 4 | 21 | 337 | 383 | 53.8 | 100.0 | ||
| 10 | | Bills | 10/13/2020 | 0-1 | -166 | @ | +141 | L 16-42 | -3 | -29 (N) | 52 | +6 (O) | 2 | 23 | 370 | 334 | 76.5 | |||
| 11 | | Bills | 10/25/2020 | 0-1 | -415 | @ | +330 | W 18-10 | -9.5 | -1.5 (N) | 46.5 | -18.5 (U) | 0 | 26 | 422 | 191 | 27.3 | |||
| 12 | | Bills | 11/1/2020 | 0-1 | -206 | vs | +172 | W 24-21 | -4 | -1 (N) | 41 | +4 (O) | 3 | 22 | 339 | 349 | 45.5 | |||
| 13 | | Bills | 11/29/2020 | 1-0 | -217 | vs | +180 | W 27-17 | -4 | +6 (Y) | 51 | -7 (U) | 3 | 23 | 332 | 367 | 44.4 | |||
| 14 | | Bills | 12/13/2020 | 1-0 | -132 | vs | +112 | W 26-15 | -2 | +9 (Y) | 48.5 | -7.5 (U) | 3 | 21 | 334 | 224 | 50.0 | |||
| 15 | | Bills | 12/19/2020 | 1-0 | -249 | @ | +209 | W 48-19 | -6 | +23 (Y) | 48.5 | +18.5 (O) | 6 | 29 | 534 | 255 | 69.2 | 0.0 | ||
| 16 | | Bills | 12/28/2020 | 1-0 | -349 | @ | +275 | W 38-9 | -7 | +22 (Y) | 47 | 0 (P) | 5 | 31 | 474 | 201 | 41.7 | 100.0 | ||
| 17 | | Bills | 9/12/2021 | 0-1 | -286 | vs | +229 | L 16-23 | -6.5 | -13.5 (N) | 48.5 | -9.5 (U) | 1 | 22 | 371 | 252 | 44.4 | 33.3 | ||
| 18 | | Bills | 9/19/2021 | 1-0 | -188 | @ | +159 | W 35-0 | -3.5 | +31.5 (Y) | 48 | -13 (U) | 5 | 21 | 314 | 216 | 53.8 | 100.0 | ||
| 19 | | Bills | 10/3/2021 | 1-0 | -1784 | vs | +957 | W 40-0 | -19 | +21 (Y) | 47.5 | -7.5 (U) | 4 | 26 | 450 | 109 | 41.7 | 50.0 | ||
| 20 | | Bills | 10/18/2021 | 0-1 | -270 | @ | +218 | L 31-34 | -6 | -9 (N) | 53.5 | +11.5 (O) | 3 | 28 | 417 | 362 | 53.8 | 0.0 | ||
| 21 | | Bills | 10/31/2021 | 0-0-1 | -1046 | vs | +681 | W 26-11 | -15 | 0 (P) | 48.5 | -11.5 (U) | 3 | 24 | 351 | 262 | 46.2 | 0.0 | ||
| 22 | | Bills | 11/7/2021 | 0-1 | -1144 | @ | +704 | L 6-9 | -14.5 | -17.5 (N) | 48.5 | -33.5 (U) | 0 | 17 | 301 | 218 | 40.0 | 0.0 | ||
| 23 | | Bills | 11/14/2021 | 1-0 | -777 | @ | +533 | W 45-17 | -13.5 | +14.5 (Y) | 48.5 | +13.5 (O) | 6 | 26 | 489 | 366 | 57.1 | |||
| 24 | | Bills | 11/21/2021 | 0-1 | -310 | vs | +244 | L 15-41 | -7 | -33 (N) | 49.5 | +6.5 (O) | 2 | 19 | 311 | 370 | 50.0 | |||
| 25 | | Bills | 12/6/2021 | 0-1 | -147 | vs | +124 | L 10-14 | -3 | -7 (N) | 40 | -16 (U) | 1 | 16 | 230 | 241 | 30.8 | 0.0 | ||
| Average | 0.8 | 3.3 | 22.5 | 377.8 | 291.9 | 46.7 | 0.0 | |||||||||||||
| Total | 35-32-1 | 222 | 1,528 | 25,693 | 19,846 | 46.7 | 57.8 | |||||||||||||
BUF
NYJ
MIA
CIN
DEN
NYJ
LV
TEN
NE
LAC
PIT
HOU
JAX
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More Bills Stats
Team Leaders 
PASS
786
Allen
RUSH
346
Cook
REC
263
Kincaid
Team Rankings
PPG
33.7
1st
OPP PPG
26.0
21st
RUSH YDS/G
155.0
4th
PASS YDS/G
262.0
10th
Jets
LAR
BAL
MIN
NFL 2026 Leaders
NFL 2026 Rankings
NFL Fantasy 2026
NFL 2026 Betting
NFL 2026 Standings
| NFC East | W | L | T | PCT |
|---|---|---|---|---|
2 | 1 | 0 | .667 | |
2 | 1 | 0 | .667 | |
1 | 2 | 0 | .333 | |
1 | 2 | 0 | .333 | |
| NFC North | W | L | T | PCT |
3 | 0 | 0 | 1.000 | |
2 | 1 | 0 | .667 | |
2 | 1 | 0 | .667 | |
1 | 2 | 0 | .333 | |
| NFC South | W | L | T | PCT |
1 | 2 | 0 | .333 | |
1 | 2 | 0 | .333 | |
1 | 2 | 0 | .333 | |
0 | 3 | 0 | .000 | |
| NFC West | W | L | T | PCT |
3 | 0 | 0 | 1.000 | |
2 | 1 | 0 | .667 | |
1 | 2 | 0 | .333 | |
1 | 2 | 0 | .333 |
Eagles
Giants
Cowboys
Commanders
Lions
Bears
Packers
Panthers
Saints
Falcons
Buccaneers
49ers
Seahawks
Cardinals| AFC East | W | L | T | PCT |
|---|---|---|---|---|
3 | 0 | 0 | 1.000 | |
1 | 2 | 0 | .333 | |
1 | 2 | 0 | .333 | |
0 | 3 | 0 | .000 | |
| AFC North | W | L | T | PCT |
2 | 1 | 0 | .667 | |
2 | 1 | 0 | .667 | |
2 | 1 | 0 | .667 | |
2 | 1 | 0 | .667 | |
| AFC South | W | L | T | PCT |
2 | 1 | 0 | .667 | |
1 | 2 | 0 | .333 | |
0 | 3 | 0 | .000 | |
0 | 3 | 0 | .000 | |
| AFC West | W | L | T | PCT |
3 | 0 | 0 | 1.000 | |
3 | 0 | 0 | 1.000 | |
2 | 1 | 0 | .667 | |
0 | 3 | 0 | .000 |
Browns
Chiefs