The Buffalo Bills are 13-9-1 against the spread as underdogs against the AFC South in their last 25 games.
| TEAM | DATE | ATS | TM | OPP | RESULT | SPREAD | ATS DIFF | O/U | O/U DIFF | TD | 1DWN | OFF | OPP OFF | 3DWN% | 4DWN% | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | Bills | 11/23/2003 | 0-0-1 | vs | L 14-17 | +3 | 0 (P) | 37.5 | -6.5 (U) | 2 | 16 | 228 | 326 | 23.1 | 100.0 | ||||
| 2 | | Bills | 12/14/2003 | 1-0 | @ | L 26-28 | +6 | +4 (Y) | 38 | +16 (O) | 3 | 13 | 241 | 349 | 16.7 | 100.0 | ||||
| 3 | | Bills | 11/12/2006 | 1-0 | +525 | @ | -725 | L 16-17 | +12 | +11 (Y) | 45 | -12 (U) | 1 | 10 | 162 | 384 | 35.7 | 100.0 | ||
| 4 | | Bills | 11/19/2006 | 1-0 | +135 | @ | -155 | W 24-21 | +2 | +5 (Y) | 36 | +9 (O) | 3 | 17 | 403 | 394 | 28.6 | 100.0 | ||
| 5 | | Bills | 11/26/2006 | 1-0 | +140 | vs | -160 | W 27-24 | +3 | +6 (Y) | 35 | +16 (O) | 3 | 13 | 241 | 323 | 30.0 | |||
| 6 | | Bills | 11/25/2007 | 0-1 | +325 | @ | -430 | L 14-36 | +8.5 | -13.5 (N) | 37 | +13 (O) | 2 | 20 | 297 | 416 | 56.3 | 50.0 | ||
| 7 | | Bills | 9/14/2008 | 1-0 | +170 | @ | -200 | W 20-16 | +4.5 | +8.5 (Y) | 37 | -1 (U) | 2 | 18 | 285 | 243 | 54.5 | |||
| 8 | | Bills | 11/1/2009 | 0-1 | +165 | vs | -190 | L 10-31 | +3 | -18 (N) | 41.5 | -0.5 (U) | 1 | 9 | 204 | 439 | 20.0 | 0.0 | ||
| 9 | | Bills | 11/15/2009 | 0-1 | +300 | @ | -360 | L 17-41 | +8 | -16 (N) | 40.5 | +17.5 (O) | 2 | 14 | 296 | 378 | 35.7 | 0.0 | ||
| 10 | | Bills | 11/22/2009 | 1-0 | +310 | @ | -375 | L 15-18 | +8.5 | +5.5 (Y) | 43 | -10 (U) | 1 | 14 | 343 | 310 | 27.3 | 0.0 | ||
| 11 | | Bills | 11/4/2012 | 0-1 | +450 | @ | -600 | L 9-21 | +11 | -1 (N) | 48 | -18 (U) | 0 | 17 | 304 | 374 | 18.2 | 100.0 | ||
| 12 | | Bills | 11/25/2012 | 0-1 | +115 | @ | -135 | L 13-20 | +2 | -5 (N) | 51 | -18 (U) | 1 | 16 | 304 | 312 | 30.8 | |||
| 13 | | Bills | 9/28/2014 | 0-1 | +130 | @ | -150 | L 17-23 | +3 | -3 (N) | 44 | -4 (U) | 2 | 17 | 316 | 301 | 31.3 | |||
| 14 | | Bills | 9/13/2015 | 1-0 | -105 | vs | -115 | W 27-14 | +1 | +14 (Y) | 44 | -3 (U) | 3 | 15 | 342 | 304 | 38.5 | |||
| 15 | | Bills | 1/7/2018 | 1-0 | +355 | @ | -400 | L 3-10 | +8.5 | +1.5 (Y) | 40 | -27 (U) | 0 | 20 | 263 | 230 | 38.9 | 100.0 | ||
| 16 | | Bills | 10/7/2018 | 1-0 | +248 | vs | -270 | W 13-12 | +6.5 | +7.5 (Y) | 38 | -13 (U) | 1 | 18 | 223 | 221 | 30.8 | 66.7 | ||
| 17 | | Bills | 10/14/2018 | 1-0 | +405 | @ | -455 | L 13-20 | +10 | +3 (Y) | 40.5 | -7.5 (U) | 1 | 12 | 229 | 216 | 40.0 | |||
| 18 | | Bills | 10/21/2018 | 0-1 | +260 | @ | -290 | L 5-37 | +7 | -25 (N) | 43.5 | -1.5 (U) | 0 | 15 | 303 | 376 | 22.2 | 0.0 | ||
| 19 | | Bills | 11/25/2018 | 1-0 | +147 | vs | -157 | W 24-21 | +3 | +6 (Y) | 36.5 | +8.5 (O) | 3 | 18 | 327 | 333 | 20.0 | |||
| 20 | | Bills | 10/6/2019 | 1-0 | +126 | @ | -153 | W 14-7 | +2.5 | +9.5 (Y) | 39.5 | -18.5 (U) | 2 | 18 | 313 | 252 | 30.8 | 50.0 | ||
| 21 | | Bills | 1/4/2020 | 0-1 | +121 | @ | -146 | L 19-22 | +2.5 | -0.5 (N) | 43 | -2 (U) | 1 | 24 | 425 | 360 | 52.4 | 0.0 | ||
| 22 | | Bills | 10/6/2024 | 0-1 | +103 | @ | -122 | L 20-23 | +1.5 | -1.5 (N) | 48 | -5 (U) | 2 | 16 | 276 | 425 | 21.4 | 100.0 | ||
| 23 | | Bills | 1/11/2026 | 1-0 | +106 | @ | -126 | W 27-24 | +1.5 | +4.5 (Y) | 51.5 | -0.5 (U) | 3 | 20 | 340 | 359 | 50.0 | 100.0 | ||
| Average | 2.6 | 1.7 | 16.1 | 289.8 | 331.5 | 34.1 | 0.0 | |||||||||||||
| Total | 13-9-1 | 39 | 370 | 6,665 | 7,625 | 34.1 | 65.2 |
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More Bills Stats
Team Leaders 
PASS
1,039
Allen
RUSH
421
Cook
REC
270
Kincaid
Team Rankings
PPG
31.8
2nd
OPP PPG
26.8
25th
RUSH YDS/G
139.0
6th
PASS YDS/G
259.8
10th
Patriots
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Dolphins
LV
BAL
MIN
NFL 2026 Leaders
NFL 2026 Rankings
NFL Fantasy 2026
NFL 2026 Betting
NFL 2026 Standings
| NFC East | W | L | T | PCT |
|---|---|---|---|---|
3 | 1 | 1 | .700 | |
2 | 3 | 0 | .400 | |
2 | 3 | 0 | .400 | |
1 | 3 | 1 | .300 | |
| NFC North | W | L | T | PCT |
5 | 0 | 0 | 1.000 | |
3 | 2 | 0 | .600 | |
3 | 2 | 0 | .600 | |
3 | 2 | 0 | .600 | |
| NFC South | W | L | T | PCT |
2 | 2 | 0 | .500 | |
2 | 3 | 0 | .400 | |
1 | 4 | 0 | .200 | |
1 | 4 | 0 | .200 | |
| NFC West | W | L | T | PCT |
5 | 0 | 0 | 1.000 | |
3 | 2 | 0 | .600 | |
2 | 2 | 0 | .500 | |
1 | 4 | 0 | .200 |
Giants
Eagles
Cowboys
Commanders
Packers
Lions
Bears
Panthers
Falcons
Buccaneers
Saints
49ers
Seahawks
Rams
Cardinals| AFC East | W | L | T | PCT |
|---|---|---|---|---|
3 | 1 | 0 | .750 | |
3 | 2 | 0 | .600 | |
2 | 3 | 0 | .400 | |
0 | 5 | 0 | .000 | |
| AFC North | W | L | T | PCT |
4 | 1 | 0 | .800 | |
3 | 2 | 0 | .600 | |
3 | 2 | 0 | .600 | |
3 | 2 | 0 | .600 | |
| AFC South | W | L | T | PCT |
4 | 1 | 0 | .800 | |
2 | 3 | 0 | .400 | |
1 | 4 | 0 | .200 | |
0 | 5 | 0 | .000 | |
| AFC West | W | L | T | PCT |
4 | 0 | 0 | 1.000 | |
3 | 2 | 0 | .600 | |
3 | 2 | 0 | .600 | |
0 | 5 | 0 | .000 |
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Steelers
Bengals
Chiefs
Broncos
Chargers