The Buffalo Bills have a record of 97-92-5 against the spread in the regular season against the AFC since 2010.
| TEAM | DATE | ATS | TM | OPP | RESULT | SPREAD | ATS DIFF | O/U | O/U DIFF | TD | 1DWN | OFF | OPP OFF | 3DWN% | 4DWN% | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | Bills | 9/12/2010 | 0-1 | +150 | vs | -170 | L 10-15 | +3 | -2 (N) | 39.5 | -14.5 (U) | 1 | 9 | 166 | 296 | 21.4 | 33.3 | ||
| 2 | | Bills | 9/26/2010 | 1-0 | +725 | @ | -1050 | L 30-38 | +14.5 | +6.5 (Y) | 42.5 | +25.5 (O) | 3 | 19 | 374 | 445 | 50.0 | |||
| 3 | | Bills | 10/3/2010 | 0-1 | +210 | vs | -250 | L 14-38 | +5.5 | -18.5 (N) | 36.5 | +15.5 (O) | 2 | 12 | 223 | 444 | 0.0 | 100.0 | ||
| 4 | | Bills | 10/10/2010 | 0-1 | -140 | vs | +120 | L 26-36 | -1 | -11 (N) | 41 | +21 (O) | 3 | 17 | 306 | 381 | 27.3 | 0.0 | ||
| 5 | | Bills | 10/24/2010 | 1-0 | +500 | @ | -700 | L 34-37 | +12.5 | +9.5 (Y) | 39.5 | +31.5 (O) | 4 | 27 | 514 | 364 | 64.7 | 50.0 | ||
| 6 | | Bills | 10/31/2010 | 1-0 | +265 | @ | -325 | L 10-13 | +7 | +4 (Y) | 45.5 | -22.5 (U) | 1 | 23 | 328 | 414 | 47.8 | 50.0 | ||
| 7 | | Bills | 11/21/2010 | 1-0 | +185 | @ | -225 | W 49-31 | +5.5 | +23.5 (Y) | 41.5 | +38.5 (O) | 7 | 23 | 449 | 361 | 50.0 | 100.0 | ||
| 8 | | Bills | 11/28/2010 | 1-0 | +250 | vs | -300 | L 16-19 | +6.5 | +3.5 (Y) | 43.5 | -8.5 (U) | 1 | 19 | 329 | 426 | 30.8 | 100.0 | ||
| 9 | | Bills | 12/12/2010 | 1-0 | -110 | vs | -110 | W 13-6 | -1 | +6 (Y) | 39 | -20 (U) | 1 | 19 | 323 | 187 | 35.7 | 50.0 | ||
| 10 | | Bills | 12/19/2010 | 1-0 | +210 | @ | -250 | W 17-14 | +5.5 | +8.5 (Y) | 40 | -9 (U) | 2 | 15 | 282 | 326 | 33.3 | 100.0 | ||
| 11 | | Bills | 12/26/2010 | 0-1 | +290 | vs | -350 | L 3-34 | +7 | -24 (N) | 45 | -8 (U) | 0 | 16 | 369 | 348 | 30.0 | 33.3 | ||
| 12 | | Bills | 1/2/2011 | 0-1 | +100 | @ | -120 | L 7-38 | +1 | -30 (N) | 38 | +7 (O) | 1 | 6 | 162 | 388 | 33.3 | |||
| 13 | | Bills | 9/11/2011 | 1-0 | +180 | @ | -210 | W 41-7 | +4 | +38 (Y) | 40 | +8 (O) | 5 | 23 | 364 | 213 | 50.0 | |||
| 14 | | Bills | 9/18/2011 | 0-1 | -200 | vs | +175 | W 38-35 | -4 | -1 (N) | 41 | +32 (O) | 5 | 34 | 481 | 454 | 36.4 | 100.0 | ||
| 15 | | Bills | 9/25/2011 | 1-0 | +280 | vs | -340 | W 34-31 | +7 | +10 (Y) | 54 | +11 (O) | 4 | 24 | 448 | 495 | 36.4 | 0.0 | ||
| 16 | | Bills | 10/2/2011 | 0-1 | -155 | @ | +135 | L 20-23 | -3 | -6 (N) | 43 | 0 (P) | 2 | 12 | 273 | 458 | 28.6 | |||
| 17 | | Bills | 11/6/2011 | 0-1 | -135 | vs | +115 | L 11-27 | -2.5 | -18.5 (N) | 45 | -7 (U) | 1 | 14 | 287 | 348 | 27.3 | 33.3 | ||
| 18 | | Bills | 11/20/2011 | 0-1 | +130 | @ | -150 | L 8-35 | +3 | -24 (N) | 43.5 | -0.5 (U) | 0 | 14 | 245 | 242 | 0.0 | 0.0 | ||
| 19 | | Bills | 11/27/2011 | 1-0 | +400 | @ | -500 | L 24-28 | +9.5 | +5.5 (Y) | 42.5 | +9.5 (O) | 3 | 21 | 336 | 318 | 40.0 | 0.0 | ||
| 20 | | Bills | 12/4/2011 | 0-1 | -120 | vs | +100 | L 17-23 | -1 | -7 (N) | 42.5 | -2.5 (U) | 2 | 18 | 386 | 317 | 43.8 | 50.0 | ||
| 21 | | Bills | 12/11/2011 | 0-1 | +280 | @ | -340 | L 10-37 | +7 | -20 (N) | 48.5 | -1.5 (U) | 1 | 17 | 281 | 366 | 36.4 | 0.0 | ||
| 22 | | Bills | 12/18/2011 | 0-1 | -110 | vs | -110 | L 23-30 | -1 | -8 (N) | 42 | +11 (O) | 3 | 21 | 404 | 448 | 0.0 | 100.0 | ||
| 23 | | Bills | 12/24/2011 | 1-0 | +130 | vs | -150 | W 40-14 | +3 | +29 (Y) | 42.5 | +11.5 (O) | 4 | 14 | 351 | 285 | 16.7 | |||
| 24 | | Bills | 1/1/2012 | 0-1 | +425 | @ | -600 | L 21-49 | +10.5 | -17.5 (N) | 50 | +20 (O) | 3 | 26 | 402 | 480 | 14.3 | 66.7 | ||
| 25 | | Bills | 9/9/2012 | 0-1 | +130 | @ | -150 | L 28-48 | +3 | -17 (N) | 42.5 | +33.5 (O) | 4 | 20 | 390 | 384 | 66.7 | 100.0 | ||
| Average | 0.3 | 2.7 | 20.0 | 348.9 | 325.8 | 40.2 | 0.0 | |||||||||||||
| Total | 97-92-5 | 533 | 3,877 | 67,685 | 63,213 | 40.2 | 50.0 | |||||||||||||
BUF
MIA
NE
NYJ
JAX
BAL
KC
CIN
PIT
CLE
OAK
TEN
SD
DENStatMuse has team, game-level data for spread records going back to the 1979 season.
More NFL News
Patriots hit by another injury blow as Mack Hollins lands on IR ahead of Raiders game
Packers place running back Chris Brooks on injured reserve due to ankle problem
Cardinals WR Marvin Harrison Jr. will be inactive vs. Lions, AP source says as trade rumors swirl
Jets activate wide receiver Tim Patrick off injured reserve ahead of Browns game
Bills coach Joe Brady rules out DT Ed Oliver and WR Joshua Palmer from playing against the LA Rams
It’s special: Philly-style dive bar in London a hit with Eagles fans from US and UK
More Bills Stats
Team Leaders 
PASS
1,039
Allen
RUSH
421
Cook
REC
270
Kincaid
Team Rankings
PPG
31.8
1st
OPP PPG
26.8
25th
RUSH YDS/G
139.0
5th
PASS YDS/G
259.8
9th
Jets
LAR
MIN
NFL 2026 Leaders
NFL 2026 Rankings
NFL Fantasy 2026
NFL 2026 Betting
NFL 2026 Standings
| NFC East | W | L | T | PCT |
|---|---|---|---|---|
3 | 1 | 0 | .750 | |
2 | 2 | 0 | .500 | |
2 | 3 | 0 | .400 | |
1 | 3 | 0 | .250 | |
| NFC North | W | L | T | PCT |
4 | 0 | 0 | 1.000 | |
3 | 1 | 0 | .750 | |
2 | 2 | 0 | .500 | |
2 | 2 | 0 | .500 | |
| NFC South | W | L | T | PCT |
2 | 2 | 0 | .500 | |
2 | 2 | 0 | .500 | |
1 | 3 | 0 | .250 | |
1 | 4 | 0 | .200 | |
| NFC West | W | L | T | PCT |
4 | 0 | 0 | 1.000 | |
3 | 1 | 0 | .750 | |
2 | 2 | 0 | .500 | |
1 | 3 | 0 | .250 |
Giants
Eagles
Cowboys
Commanders
Bears
Lions
Packers
Panthers
Falcons
Saints
Buccaneers
49ers
Seahawks
Cardinals| AFC East | W | L | T | PCT |
|---|---|---|---|---|
3 | 1 | 0 | .750 | |
2 | 2 | 0 | .500 | |
1 | 3 | 0 | .250 | |
0 | 4 | 0 | .000 | |
| AFC North | W | L | T | PCT |
3 | 1 | 0 | .750 | |
3 | 1 | 0 | .750 | |
2 | 2 | 0 | .500 | |
2 | 2 | 0 | .500 | |
| AFC South | W | L | T | PCT |
3 | 1 | 0 | .750 | |
2 | 2 | 0 | .500 | |
0 | 4 | 0 | .000 | |
0 | 4 | 0 | .000 | |
| AFC West | W | L | T | PCT |
4 | 0 | 0 | 1.000 | |
3 | 1 | 0 | .750 | |
2 | 2 | 0 | .500 | |
0 | 4 | 0 | .000 |
Colts
Texans