The Buffalo Bills have a 15-12-2 record against the spread as favorites in the regular season against the NFC since 2017.
| TEAM | DATE | ATS | TM | OPP | RESULT | SPREAD | ATS DIFF | O/U | O/U DIFF | TD | 1DWN | OFF | OPP OFF | 3DWN% | 4DWN% | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | Bills | 10/22/2017 | 0-0-1 | -165 | vs | +155 | W 30-27 | -3 | 0 (P) | 46.5 | +10.5 (O) | 3 | 23 | 434 | 447 | 62.5 | |||
| 2 | | Bills | 12/16/2018 | 0-1 | -145 | vs | +135 | W 14-13 | -2.5 | -1.5 (N) | 39.5 | -12.5 (U) | 2 | 20 | 312 | 313 | 25.0 | 50.0 | ||
| 3 | | Bills | 9/15/2019 | 1-0 | -125 | @ | +102 | W 28-14 | -1.5 | +12.5 (Y) | 43.5 | -1.5 (U) | 4 | 24 | 388 | 370 | 38.5 | |||
| 4 | | Bills | 10/27/2019 | 0-1 | -115 | vs | -105 | L 13-31 | -1 | -19 (N) | 39.5 | +4.5 (O) | 2 | 16 | 253 | 371 | 40.0 | 0.0 | ||
| 5 | | Bills | 11/3/2019 | 1-0 | -568 | vs | +419 | W 24-9 | -10.5 | +4.5 (Y) | 37 | -4 (U) | 3 | 18 | 268 | 243 | 50.0 | 50.0 | ||
| 6 | | Bills | 9/27/2020 | 1-0 | -124 | vs | +105 | W 35-32 | -1.5 | +1.5 (Y) | 46.5 | +20.5 (O) | 5 | 23 | 375 | 478 | 50.0 | 100.0 | ||
| 7 | | Bills | 9/26/2021 | 1-0 | -346 | vs | +270 | W 43-21 | -7 | +15 (Y) | 45.5 | +18.5 (O) | 5 | 29 | 481 | 290 | 60.0 | 0.0 | ||
| 8 | | Bills | 11/25/2021 | 1-0 | -302 | @ | +239 | W 31-6 | -7 | +18 (Y) | 45 | -8 (U) | 4 | 21 | 361 | 190 | 61.5 | 100.0 | ||
| 9 | | Bills | 12/19/2021 | 1-0 | -834 | vs | +557 | W 31-14 | -14.5 | +2.5 (Y) | 43 | +2 (O) | 4 | 21 | 312 | 275 | 42.9 | 100.0 | ||
| 10 | | Bills | 1/2/2022 | 0-0-1 | -947 | vs | +625 | W 29-15 | -14 | 0 (P) | 46 | -2 (U) | 4 | 28 | 351 | 265 | 58.3 | 100.0 | ||
| 11 | | Bills | 9/8/2022 | 1-0 | -131 | @ | +110 | W 31-10 | -2.5 | +18.5 (Y) | 52 | -11 (U) | 4 | 23 | 413 | 243 | 90.0 | |||
| 12 | | Bills | 10/30/2022 | 0-1 | -502 | vs | +381 | W 27-17 | -10.5 | -0.5 (N) | 47 | -3 (U) | 3 | 20 | 369 | 398 | 28.6 | |||
| 13 | | Bills | 11/13/2022 | 0-1 | -274 | vs | +222 | L 30-33 | -6.5 | -9.5 (N) | 46.5 | +16.5 (O) | 3 | 29 | 486 | 481 | 53.8 | 0.0 | ||
| 14 | | Bills | 11/24/2022 | 0-1 | -433 | @ | +338 | W 28-25 | -9.5 | -6.5 (N) | 54.5 | -1.5 (U) | 3 | 28 | 401 | 326 | 58.3 | |||
| 15 | | Bills | 12/24/2022 | 1-0 | -398 | @ | +312 | W 35-13 | -8 | +14 (Y) | 40.5 | +7.5 (O) | 5 | 20 | 426 | 209 | 54.5 | 100.0 | ||
| 16 | | Bills | 9/24/2023 | 1-0 | -235 | @ | +194 | W 37-3 | -5 | +29 (Y) | 44 | -4 (U) | 4 | 20 | 386 | 230 | 60.0 | 0.0 | ||
| 17 | | Bills | 10/15/2023 | 0-1 | -1216 | vs | +750 | W 14-9 | -15 | -10 (N) | 43.5 | -20.5 (U) | 2 | 22 | 297 | 317 | 50.0 | |||
| 18 | | Bills | 10/26/2023 | 0-1 | -516 | vs | +384 | W 24-18 | -10 | -4 (N) | 43 | -1 (U) | 3 | 25 | 427 | 302 | 53.8 | 0.0 | ||
| 19 | | Bills | 12/17/2023 | 1-0 | -139 | vs | +117 | W 31-10 | -2.5 | +18.5 (Y) | 49 | -8 (U) | 4 | 28 | 351 | 195 | 55.6 | |||
| 20 | | Bills | 9/8/2024 | 0-1 | -308 | vs | +246 | W 34-28 | -6.5 | -0.5 (N) | 45.5 | +16.5 (O) | 4 | 23 | 352 | 270 | 33.3 | 100.0 | ||
| 21 | | Bills | 10/27/2024 | 1-0 | -163 | @ | +137 | W 31-10 | -3 | +18 (Y) | 45.5 | -4.5 (U) | 4 | 29 | 445 | 233 | 53.3 | 100.0 | ||
| 22 | | Bills | 12/1/2024 | 1-0 | -330 | vs | +265 | W 35-10 | -6.5 | +18.5 (Y) | 45.5 | -0.5 (U) | 5 | 20 | 372 | 239 | 50.0 | 100.0 | ||
| 23 | | Bills | 12/8/2024 | 0-1 | -191 | @ | +158 | L 42-44 | -3.5 | -5.5 (N) | 50 | +36 (O) | 6 | 25 | 445 | 457 | 55.6 | |||
| 24 | | Bills | 9/28/2025 | 0-1 | -1389 | vs | +833 | W 31-19 | -14.5 | -2.5 (N) | 48.5 | +1.5 (O) | 4 | 20 | 356 | 298 | 30.0 | 0.0 | ||
| 25 | | Bills | 10/13/2025 | 0-1 | -203 | @ | +169 | L 14-24 | -3.5 | -13.5 (N) | 49.5 | -11.5 (U) | 2 | 17 | 291 | 443 | 22.2 | 0.0 | ||
| Average | 1.9 | 3.8 | 23.0 | 377.7 | 311.7 | 51.1 | 0.0 | |||||||||||||
| Total | 15-12-2 | 111 | 668 | 10,953 | 9,039 | 51.1 | 53.8 | |||||||||||||
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PASS
786
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346
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REC
263
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33.7
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26.0
21st
RUSH YDS/G
155.0
4th
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262.0
10th
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| NFC East | W | L | T | PCT |
|---|---|---|---|---|
2 | 0 | 0 | 1.000 | |
2 | 1 | 0 | .667 | |
1 | 2 | 0 | .333 | |
1 | 2 | 0 | .333 | |
| NFC North | W | L | T | PCT |
3 | 0 | 0 | 1.000 | |
2 | 1 | 0 | .667 | |
1 | 1 | 0 | .500 | |
1 | 2 | 0 | .333 | |
| NFC South | W | L | T | PCT |
1 | 2 | 0 | .333 | |
1 | 2 | 0 | .333 | |
1 | 2 | 0 | .333 | |
0 | 3 | 0 | .000 | |
| NFC West | W | L | T | PCT |
3 | 0 | 0 | 1.000 | |
2 | 1 | 0 | .667 | |
1 | 2 | 0 | .333 | |
1 | 2 | 0 | .333 |
Bears| AFC East | W | L | T | PCT |
|---|---|---|---|---|
3 | 0 | 0 | 1.000 | |
1 | 2 | 0 | .333 | |
1 | 2 | 0 | .333 | |
0 | 3 | 0 | .000 | |
| AFC North | W | L | T | PCT |
2 | 1 | 0 | .667 | |
2 | 1 | 0 | .667 | |
2 | 1 | 0 | .667 | |
2 | 1 | 0 | .667 | |
| AFC South | W | L | T | PCT |
2 | 1 | 0 | .667 | |
1 | 2 | 0 | .333 | |
0 | 3 | 0 | .000 | |
0 | 3 | 0 | .000 | |
| AFC West | W | L | T | PCT |
3 | 0 | 0 | 1.000 | |
3 | 0 | 0 | 1.000 | |
2 | 1 | 0 | .667 | |
0 | 3 | 0 | .000 |
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