The Buffalo Bills have a 16-20-1 record against the spread as favorites in the regular season and playoffs against the AFC on the road since 2014.
| TEAM | DATE | ATS | TM | OPP | RESULT | SPREAD | ATS DIFF | O/U | O/U DIFF | TD | 1DWN | OFF | OPP OFF | 3DWN% | 4DWN% | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | Bills | 12/21/2014 | 0-1 | -280 | @ | +240 | L 24-26 | -7 | -9 (N) | 42 | +8 (O) | 3 | 15 | 321 | 347 | 26.7 | |||
| 2 | | Bills | 10/11/2015 | 0-0-1 | -115 | @ | -105 | W 14-13 | -1 | 0 (P) | 43 | -16 (U) | 2 | 13 | 209 | 276 | 33.3 | |||
| 3 | | Bills | 10/25/2015 | 0-1 | -200 | @ | +160 | L 31-34 | -4 | -7 (N) | 42 | +23 (O) | 3 | 26 | 375 | 295 | 25.0 | 0.0 | ||
| 4 | | Bills | 10/23/2016 | 0-1 | -140 | @ | +120 | L 25-28 | -2.5 | -5.5 (N) | 46 | +7 (O) | 3 | 16 | 267 | 454 | 23.1 | |||
| 5 | | Bills | 1/1/2017 | 0-1 | -222 | @ | +180 | L 10-30 | -4.5 | -24.5 (N) | 43 | -3 (U) | 1 | 14 | 230 | 329 | 37.5 | 0.0 | ||
| 6 | | Bills | 11/2/2017 | 0-1 | -170 | @ | +160 | L 21-34 | -3 | -16 (N) | 42 | +13 (O) | 3 | 21 | 307 | 331 | 37.5 | 0.0 | ||
| 7 | | Bills | 12/31/2017 | 1-0 | -135 | @ | +125 | W 22-16 | -2.5 | +3.5 (Y) | 41.5 | -3.5 (U) | 2 | 23 | 312 | 356 | 41.7 | |||
| 8 | | Bills | 11/17/2019 | 1-0 | -352 | @ | +274 | W 37-20 | -7 | +10 (Y) | 41.5 | +15.5 (O) | 4 | 22 | 424 | 303 | 35.7 | 100.0 | ||
| 9 | | Bills | 9/20/2020 | 0-1 | -229 | @ | +192 | W 31-28 | -5.5 | -2.5 (N) | 42 | +17 (O) | 4 | 23 | 523 | 410 | 50.0 | |||
| 10 | | Bills | 10/4/2020 | 1-0 | -178 | @ | +148 | W 30-23 | -3.5 | +3.5 (Y) | 52.5 | +0.5 (O) | 4 | 21 | 337 | 383 | 53.8 | 100.0 | ||
| 11 | | Bills | 10/13/2020 | 0-1 | -166 | @ | +141 | L 16-42 | -3 | -29 (N) | 52 | +6 (O) | 2 | 23 | 370 | 334 | 76.5 | |||
| 12 | | Bills | 10/25/2020 | 0-1 | -415 | @ | +330 | W 18-10 | -9.5 | -1.5 (N) | 46.5 | -18.5 (U) | 0 | 26 | 422 | 191 | 27.3 | |||
| 13 | | Bills | 12/19/2020 | 1-0 | -249 | @ | +209 | W 48-19 | -6 | +23 (Y) | 48.5 | +18.5 (O) | 6 | 29 | 534 | 255 | 69.2 | 0.0 | ||
| 14 | | Bills | 12/28/2020 | 1-0 | -349 | @ | +275 | W 38-9 | -7 | +22 (Y) | 47 | 0 (P) | 5 | 31 | 474 | 201 | 41.7 | 100.0 | ||
| 15 | | Bills | 9/19/2021 | 1-0 | -188 | @ | +159 | W 35-0 | -3.5 | +31.5 (Y) | 48 | -13 (U) | 5 | 21 | 314 | 216 | 53.8 | 100.0 | ||
| 16 | | Bills | 10/18/2021 | 0-1 | -270 | @ | +218 | L 31-34 | -6 | -9 (N) | 53.5 | +11.5 (O) | 3 | 28 | 417 | 362 | 53.8 | 0.0 | ||
| 17 | | Bills | 11/7/2021 | 0-1 | -1144 | @ | +704 | L 6-9 | -14.5 | -17.5 (N) | 48.5 | -33.5 (U) | 0 | 17 | 301 | 218 | 40.0 | 0.0 | ||
| 18 | | Bills | 11/14/2021 | 1-0 | -777 | @ | +533 | W 45-17 | -13.5 | +14.5 (Y) | 48.5 | +13.5 (O) | 6 | 26 | 489 | 366 | 57.1 | |||
| 19 | | Bills | 9/25/2022 | 0-1 | -206 | @ | +171 | L 19-21 | -4.5 | -6.5 (N) | 54.5 | -14.5 (U) | 2 | 31 | 497 | 212 | 61.1 | 66.7 | ||
| 20 | | Bills | 10/2/2022 | 0-1 | -173 | @ | +144 | W 23-20 | -3.5 | -0.5 (N) | 50.5 | -7.5 (U) | 2 | 22 | 326 | 296 | 36.4 | 100.0 | ||
| 21 | | Bills | 10/16/2022 | 1-0 | -148 | @ | +124 | W 24-20 | -2.5 | +1.5 (Y) | 54 | -10 (U) | 3 | 26 | 443 | 387 | 36.4 | 33.3 | ||
| 22 | | Bills | 11/6/2022 | 0-1 | -562 | @ | +410 | L 17-20 | -10.5 | -13.5 (N) | 46 | -9 (U) | 2 | 19 | 317 | 310 | 61.5 | 0.0 | ||
| 23 | | Bills | 12/1/2022 | 1-0 | -204 | @ | +170 | W 24-10 | -4 | +10 (Y) | 43.5 | -9.5 (U) | 3 | 22 | 355 | 242 | 60.0 | |||
| 24 | | Bills | 9/11/2023 | 0-1 | -137 | @ | +116 | L 16-22 | -2.5 | -8.5 (N) | 44.5 | -6.5 (U) | 1 | 19 | 314 | 289 | 38.5 | |||
| 25 | | Bills | 10/22/2023 | 0-1 | -402 | @ | +313 | L 25-29 | -7.5 | -11.5 (N) | 41 | +13 (O) | 3 | 24 | 339 | 364 | 41.7 | 66.7 | ||
| Average | 1.2 | 2.9 | 21.7 | 366.3 | 306.7 | 44.7 | 0.0 | |||||||||||||
| Total | 16-20-1 | 108 | 804 | 13,552 | 11,349 | 44.7 | 52.1 | |||||||||||||
BUF
OAK
TEN
JAX
MIA
NYJ
NYJ
DEN
NE
BAL
KCStatMuse has team, game-level data for spread records going back to the 1979 season.
More NFL News
Kellen Moore wants the Saints to turn their focus forward after an emotional collapse
Bengals lament mistakes in all 3 phases that kept them from going 3-0
Raiders off to surprising 3-0 start as unbeaten Chiefs set to visit
Case Keenum starts at quarterback for the Bears against the Eagles
Seahawks regroup after loss, look toward hosting the Chargers on Sunday
Lions look to bring back explosive plays after they were limited in win over Jets
More Bills Stats
Team Leaders 
PASS
786
Allen
RUSH
346
Cook
REC
263
Kincaid
Team Rankings
PPG
33.7
1st
OPP PPG
26.0
21st
RUSH YDS/G
155.0
4th
PASS YDS/G
262.0
10th
Jets
LAR
MIN
NFL 2026 Leaders
NFL 2026 Rankings
NFL Fantasy 2026
NFL 2026 Betting
NFL 2026 Standings
| NFC East | W | L | T | PCT |
|---|---|---|---|---|
2 | 1 | 0 | .667 | |
2 | 1 | 0 | .667 | |
1 | 2 | 0 | .333 | |
1 | 2 | 0 | .333 | |
| NFC North | W | L | T | PCT |
3 | 0 | 0 | 1.000 | |
2 | 1 | 0 | .667 | |
2 | 1 | 0 | .667 | |
1 | 2 | 0 | .333 | |
| NFC South | W | L | T | PCT |
1 | 2 | 0 | .333 | |
1 | 2 | 0 | .333 | |
1 | 2 | 0 | .333 | |
0 | 3 | 0 | .000 | |
| NFC West | W | L | T | PCT |
3 | 0 | 0 | 1.000 | |
2 | 1 | 0 | .667 | |
1 | 2 | 0 | .333 | |
1 | 2 | 0 | .333 |
Eagles
Giants
Cowboys
Commanders
Lions
Bears
Packers
Panthers
Saints
Falcons
Buccaneers
49ers
Seahawks
Cardinals| AFC East | W | L | T | PCT |
|---|---|---|---|---|
3 | 0 | 0 | 1.000 | |
1 | 2 | 0 | .333 | |
1 | 2 | 0 | .333 | |
0 | 3 | 0 | .000 | |
| AFC North | W | L | T | PCT |
2 | 1 | 0 | .667 | |
2 | 1 | 0 | .667 | |
2 | 1 | 0 | .667 | |
2 | 1 | 0 | .667 | |
| AFC South | W | L | T | PCT |
2 | 1 | 0 | .667 | |
1 | 2 | 0 | .333 | |
0 | 3 | 0 | .000 | |
0 | 3 | 0 | .000 | |
| AFC West | W | L | T | PCT |
3 | 0 | 0 | 1.000 | |
3 | 0 | 0 | 1.000 | |
2 | 1 | 0 | .667 | |
0 | 3 | 0 | .000 |
Steelers
Browns
Bengals
Colts
Texans
Chargers