The Buffalo Bills have a 5-1 record as favorites against the Lions in the regular season and playoffs at home all-time.
| TEAM | DATE | REC | TM | OPP | RESULT | W% | TD | 1DWN | OFF | OPP OFF | 3DWN% | 4DWN% | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | Bills | 12/22/1991 | 0-1 | vs | L 14-17 | .000 | 2 | 14 | 275 | 356 | 25.0 | 0.0 | ||
| 2 | | Bills | 10/5/1997 | 1-0 | vs | W 22-13 | 1.000 | 2 | 10 | 266 | 309 | 18.2 | |||
| 3 | | Bills | 10/27/2002 | 1-0 | vs | W 24-17 | 1.000 | 3 | 23 | 343 | 282 | 42.9 | 100.0 | ||
| 4 | | Bills | 11/14/2010 | 1-0 | vs | W 14-12 | 1.000 | 2 | 12 | 288 | 390 | 33.3 | 0.0 | ||
| 5 | | Bills | 12/16/2018 | 1-0 | vs | W 14-13 | 1.000 | 2 | 20 | 312 | 313 | 25.0 | 50.0 | ||
| 6 | | Bills | 9/17/2026 | 1-0 | vs | W 41-31 | 1.000 | 6 | 34 | 446 | 355 | 75.0 | |||
| Average | .833 | 2.8 | 18.8 | 321.7 | 334.2 | 36.8 | 0.1 | ||||||||
| Total | 5-1 | .833 | 17 | 113 | 1,930 | 2,005 | 36.8 | 40.0 |
BUF
DETMore NFL News
Dak Prescott throws 3 TD passes, Javonte Williams runs for 155 yards as Cowboys beat Eagles 38-21
Ja'Marr Chase's halftime talk sparks Bengals' comeback win over Ravens
Raiders coach Klint Kubiak shuts down QB talk. Kirk Cousins remains the starter
Saints enter a pivotal 'self-scout' week as they try to avoid a 6th straight non-playoff season
Banged-up 49ers limp into their bye week after a 29-20 loss to the Falcons
Lions' Dan Campbell says his trust in Jared Goff enabled him to take a huge 4th-down gamble
More Bills Stats
Team Leaders 
PASS
1,504
Allen
RUSH
627
Cook
REC
315
Kincaid
Team Rankings
PPG
32.8
1st
OPP PPG
28.5
30th
RUSH YDS/G
148.8
2nd
PASS YDS/G
250.7
11th
Patriots
Jets
Dolphins
BAL
MIN
KC
NFL 2026 Leaders
NFL 2026 Rankings
NFL Fantasy 2026
NFL 2026 Betting
NFL 2026 Standings
| NFC East | W | L | T | PCT |
|---|---|---|---|---|
4 | 2 | 1 | .643 | |
3 | 4 | 0 | .429 | |
2 | 5 | 0 | .286 | |
1 | 4 | 1 | .250 | |
| NFC North | W | L | T | PCT |
6 | 0 | 0 | 1.000 | |
5 | 2 | 0 | .714 | |
4 | 2 | 0 | .667 | |
4 | 3 | 0 | .571 | |
| NFC South | W | L | T | PCT |
3 | 3 | 0 | .500 | |
3 | 4 | 0 | .429 | |
2 | 5 | 0 | .286 | |
2 | 5 | 0 | .286 | |
| NFC West | W | L | T | PCT |
6 | 1 | 0 | .857 | |
4 | 3 | 0 | .571 | |
3 | 4 | 0 | .429 | |
2 | 5 | 0 | .286 |
Giants
Cowboys
Eagles
Commanders
Bears
Packers
Panthers
Falcons
Buccaneers
Saints
49ers
Seahawks
Rams
Cardinals| AFC East | W | L | T | PCT |
|---|---|---|---|---|
5 | 1 | 0 | .833 | |
4 | 3 | 0 | .571 | |
2 | 5 | 0 | .286 | |
1 | 5 | 0 | .167 | |
| AFC North | W | L | T | PCT |
5 | 2 | 0 | .714 | |
5 | 2 | 0 | .714 | |
4 | 2 | 0 | .667 | |
4 | 3 | 0 | .571 | |
| AFC South | W | L | T | PCT |
4 | 2 | 0 | .667 | |
2 | 5 | 0 | .286 | |
2 | 5 | 0 | .286 | |
1 | 6 | 0 | .143 | |
| AFC West | W | L | T | PCT |
5 | 1 | 0 | .833 | |
5 | 2 | 0 | .714 | |
3 | 4 | 0 | .429 | |
0 | 6 | 0 | .000 |
Browns
Steelers
Bengals
Jaguars
Colts
Texans
Titans
Broncos
Raiders
Chargers