Between August 30, 2016 and August 30, 2026, the Buffalo Bills have had their lowest point differential in a home game versus the Saints on November 12, 2017, with a -37-point differential.
Interpreted as:
bills largest home loss in a regular-season game last 10 years| TEAM | DIFF | DATE | TM | OPP | RESULT | TD | 1DWN | OFF | OPP OFF | 3DWN% | 4DWN% | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | Bills | -37 | 11/12/2017 | vs | L 10-47 | 1 | 10 | 198 | 482 | 18.2 | 0.0 | ||
| 2 | | Bills | -32 | 11/4/2018 | vs | L 9-41 | 1 | 22 | 264 | 190 | 33.3 | 33.3 | ||
| 3 | | Bills | -26 | 11/21/2021 | vs | L 15-41 | 2 | 19 | 311 | 370 | 50.0 | |||
| 4 | | Bills | -20 | 12/3/2017 | vs | L 3-23 | 0 | 16 | 268 | 435 | 38.5 | 0.0 | ||
| 5 | | Bills | -19 | 10/29/2018 | vs | L 6-25 | 0 | 16 | 333 | 387 | 28.6 | 0.0 | ||
| 6 | | Bills | -18 | 10/27/2019 | vs | L 13-31 | 2 | 16 | 253 | 371 | 40.0 | 0.0 | ||
| 7 | | Bills | -16 | 10/30/2016 | vs | L 25-41 | 3 | 25 | 376 | 357 | 30.8 | 50.0 | ||
| 8 | | Bills | -11 | 9/16/2018 | vs | L 20-31 | 2 | 17 | 293 | 349 | 35.7 | |||
| 9 | | Bills | -9 | 10/19/2020 | vs | L 17-26 | 2 | 20 | 206 | 466 | 44.4 | |||
| 10 | | Bills | -7 | 9/12/2021 | vs | L 16-23 | 1 | 22 | 371 | 252 | 44.4 | 33.3 | ||
| 11 | | Bills | -7 | 12/29/2019 | vs | L 6-13 | 0 | 17 | 309 | 271 | 28.6 | |||
| 12 | | Bills | -7 | 12/8/2019 | vs | L 17-24 | 1 | 16 | 209 | 257 | 23.5 | 0.0 | ||
| 13 | | Bills | -7 | 12/11/2016 | vs | L 20-27 | 3 | 14 | 275 | 460 | 33.3 | |||
| 14 | | Bills | -6 | 9/29/2019 | vs | L 10-16 | 1 | 23 | 375 | 224 | 15.4 | 50.0 | ||
| 15 | | Bills | -6 | 9/15/2016 | vs | L 31-37 | 4 | 16 | 393 | 493 | 30.0 | 50.0 | ||
| 16 | | Bills | -5 | 10/8/2023 | vs | L 20-25 | 3 | 18 | 388 | 474 | 41.7 | |||
| 17 | | Bills | -4 | 12/6/2021 | vs | L 10-14 | 1 | 16 | 230 | 241 | 30.8 | 0.0 | ||
| 18 | | Bills | -4 | 12/9/2018 | vs | L 23-27 | 2 | 24 | 368 | 248 | 50.0 | |||
| 19 | | Bills | -3 | 10/5/2025 | vs | L 20-23 | 2 | 25 | 363 | 338 | 55.6 | |||
| 20 | | Bills | -3 | 11/13/2022 | vs | L 30-33 | 3 | 29 | 486 | 481 | 53.8 | 0.0 | ||
| 21 | | Bills | -3 | 12/24/2016 | vs | L 31-34 | 4 | 30 | 589 | 494 | 44.4 | 50.0 | ||
| 22 | | Bills | -2 | 11/13/2023 | vs | L 22-24 | 3 | 18 | 369 | 300 | 37.5 | 0.0 | ||
| 23 | | Bills | -1 | 12/28/2025 | vs | L 12-13 | 2 | 20 | 331 | 190 | 40.0 | 66.7 |
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More Bills Stats
Team Leaders 
PASS
3,668
Allen
RUSH
1,621
Cook
REC
719
Shakir
Team Rankings
PPG
28.3
4th
OPP PPG
21.5
12th
RUSH YDS/G
159.6
1st
PASS YDS/G
234.2
13th
NFL 2025 Leaders
NFL 2025 Rankings
NFL Fantasy 2025
NFL 2025 Betting
NFL 2025 Standings
| AFC East | W | L | T | PCT |
|---|---|---|---|---|
 Patriots - y | 14 | 3 | 0 | .824 |
 Bills - w | 12 | 5 | 0 | .706 |
 Dolphins - e | 7 | 10 | 0 | .412 |
 Jets - e | 3 | 14 | 0 | .176 |
| AFC North | W | L | T | PCT |
 Steelers - y | 10 | 7 | 0 | .588 |
 Ravens - e | 8 | 9 | 0 | .471 |
 Bengals - e | 6 | 11 | 0 | .353 |
 Browns - e | 5 | 12 | 0 | .294 |
| AFC South | W | L | T | PCT |
 Jaguars - y | 13 | 4 | 0 | .765 |
 Texans - w | 12 | 5 | 0 | .706 |
 Colts - e | 8 | 9 | 0 | .471 |
 Titans - e | 3 | 14 | 0 | .176 |
| AFC West | W | L | T | PCT |
 Broncos - z* | 14 | 3 | 0 | .824 |
 Chargers - w | 11 | 6 | 0 | .647 |
 Chiefs - e | 6 | 11 | 0 | .353 |
 Raiders - e | 3 | 14 | 0 | .176 |
| NFC East | W | L | T | PCT |
|---|---|---|---|---|
 Eagles - y | 11 | 6 | 0 | .647 |
 Cowboys - e | 7 | 9 | 1 | .441 |
 Commanders - e | 5 | 12 | 0 | .294 |
 Giants - e | 4 | 13 | 0 | .235 |
| NFC North | W | L | T | PCT |
 Bears - y | 11 | 6 | 0 | .647 |
 Packers - w | 9 | 7 | 1 | .559 |
 Vikings - e | 9 | 8 | 0 | .529 |
 Lions - e | 9 | 8 | 0 | .529 |
| NFC South | W | L | T | PCT |
 Panthers - y | 8 | 9 | 0 | .471 |
 Buccaneers - e | 8 | 9 | 0 | .471 |
 Falcons - e | 8 | 9 | 0 | .471 |
 Saints - e | 6 | 11 | 0 | .353 |
| NFC West | W | L | T | PCT |
 Seahawks - z* | 14 | 3 | 0 | .824 |
 Rams - w | 12 | 5 | 0 | .706 |
 49ers - w | 12 | 5 | 0 | .706 |
 Cardinals - e | 3 | 14 | 0 | .176 |