The Buffalo Bills scored their most points in a Week-10 game with Josh Allen against the Jets on November 14, 2021, with 45 points.
| TEAM | PTS | DATE | TM | OPP | RESULT | PASS TD | RUSH TD | RET TD | TD | FGM | XPM | XP2 | SFTY | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | Bills | 45 | 11/14/2021 |  BUF | @ |  NYJ | W 45-17 | 2 | 4 | 0 | 6 | 1 | 6 | 0 | 0 |
| 2 | | Bills | 30 | 11/10/2024 | BUF | @ |  IND | W 30-20 | 0 | 2 | 1 | 3 | 3 | 3 | 0 | 0 |
| 3 | | Bills | 30 | 11/13/2022 | BUF | vs |  MIN | L 30-33 | 1 | 2 | 0 | 3 | 3 | 3 | 0 | 0 |
| 4 | | Bills | 30 | 11/15/2020 | BUF | @ |  ARI | L 30-32 | 3 | 0 | 0 | 3 | 3 | 3 | 0 | 0 |
| 5 | | Bills | 22 | 11/13/2023 | BUF | vs |  DEN | L 22-24 | 1 | 2 | 0 | 3 | 0 | 2 | 1 | 0 |
| 6 | | Bills | 16 | 11/10/2019 | BUF | @ |  CLE | L 16-19 | 0 | 2 | 0 | 2 | 0 | 2 | 0 | 1 |
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