LeSean McCoy gained the most scrimmage yards for the Bills in a Week-2 game in 2018, with 68 yards versus the Chargers on September 16, 2018.
| NAME | YDS | DATE | TM | OPP | RUSH YDS | ATT | YPC | RUSH TD | REC YDS | REC | TRG | AVG | REC TD | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | L. McCoy | 68 | 9/16/2018 | vs | 39 | 9 | 4.3 | 0 | 29 | 4 | 4 | 7.3 | 0 | ||
| 2 |  | Z. Jones | 63 | 9/16/2018 | vs | 0 | 0 | 0 | 63 | 2 | 3 | 31.5 | 0 | |||
| 3 |  | C. Ivory | 37 | 9/16/2018 | vs | 7 | 2 | 3.5 | 1 | 30 | 1 | 2 | 30.0 | 0 | ||
| 4 |  | J. Allen | 32 | 9/16/2018 | vs | 32 | 8 | 4.0 | 0 | 0 | 0 | 0 | 0 | |||
| 5 | | R. Foster | 30 | 9/16/2018 | vs | 0 | 0 | 0 | 30 | 2 | 3 | 15.0 | 0 | |||
| 6 | | C. Clay | 29 | 9/16/2018 | vs | 0 | 0 | 0 | 29 | 2 | 3 | 14.5 | 0 | |||
| 7 | | P. DiMarco | 24 | 9/16/2018 | vs | 0 | 0 | 0 | 24 | 1 | 1 | 24.0 | 0 | |||
| 8 | | K. Benjamin | 19 | 9/16/2018 | vs | 0 | 0 | 0 | 19 | 2 | 3 | 9.5 | 1 | |||
| 9 | | M. Murphy | 13 | 9/16/2018 | vs | 6 | 3 | 2.0 | 0 | 7 | 1 | 5 | 7.0 | 0 | ||
| 10 | | L. Thomas | 7 | 9/16/2018 | vs | 0 | 0 | 0 | 7 | 1 | 1 | 7.0 | 0 | |||
| 11 | | J. Croom | 7 | 9/16/2018 | vs | 0 | 0 | 0 | 7 | 2 | 4 | 3.5 | 0 |
More Bills Stats
Team Leaders 
PASS
3,668
Allen
RUSH
1,621
Cook
REC
719
Shakir
Team Rankings
PPG
28.3
4th
OPP PPG
21.5
12th
RUSH YDS/G
159.6
1st
PASS YDS/G
234.2
13th
NFL 2025 Leaders
NFL 2025 Rankings
NFL Fantasy 2025
NFL 2025 Betting
NFL 2025 Standings
| AFC East | W | L | T | PCT |
|---|---|---|---|---|
 Patriots - y | 14 | 3 | 0 | .824 |
 Bills - w | 12 | 5 | 0 | .706 |
 Dolphins - e | 7 | 10 | 0 | .412 |
 Jets - e | 3 | 14 | 0 | .176 |
| AFC North | W | L | T | PCT |
 Steelers - y | 10 | 7 | 0 | .588 |
 Ravens - e | 8 | 9 | 0 | .471 |
 Bengals - e | 6 | 11 | 0 | .353 |
 Browns - e | 5 | 12 | 0 | .294 |
| AFC South | W | L | T | PCT |
 Jaguars - y | 13 | 4 | 0 | .765 |
 Texans - w | 12 | 5 | 0 | .706 |
 Colts - e | 8 | 9 | 0 | .471 |
 Titans - e | 3 | 14 | 0 | .176 |
| AFC West | W | L | T | PCT |
 Broncos - z* | 14 | 3 | 0 | .824 |
 Chargers - w | 11 | 6 | 0 | .647 |
 Chiefs - e | 6 | 11 | 0 | .353 |
 Raiders - e | 3 | 14 | 0 | .176 |
| NFC East | W | L | T | PCT |
|---|---|---|---|---|
 Eagles - y | 11 | 6 | 0 | .647 |
 Cowboys - e | 7 | 9 | 1 | .441 |
 Commanders - e | 5 | 12 | 0 | .294 |
 Giants - e | 4 | 13 | 0 | .235 |
| NFC North | W | L | T | PCT |
 Bears - y | 11 | 6 | 0 | .647 |
 Packers - w | 9 | 7 | 1 | .559 |
 Vikings - e | 9 | 8 | 0 | .529 |
 Lions - e | 9 | 8 | 0 | .529 |
| NFC South | W | L | T | PCT |
 Panthers - y | 8 | 9 | 0 | .471 |
 Buccaneers - e | 8 | 9 | 0 | .471 |
 Falcons - e | 8 | 9 | 0 | .471 |
 Saints - e | 6 | 11 | 0 | .353 |
| NFC West | W | L | T | PCT |
 Seahawks - z* | 14 | 3 | 0 | .824 |
 Rams - w | 12 | 5 | 0 | .706 |
 49ers - w | 12 | 5 | 0 | .706 |
 Cardinals - e | 3 | 14 | 0 | .176 |
