The Buffalo Bills have a 2-3 record against the spread in Week 1 between December 8, 2020 and December 8, 2025.
| TEAM | DATE | ATS | TM | OPP | RESULT | SPREAD | ATS DIFF | O/U | O/U DIFF | TD | 1DWN | OFF | OPP OFF | 3DWN% | 4DWN% | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 |  | Bills | 9/12/2021 | 0-1 |  BUF | -286 | vs |  PIT | +229 | L 16-23 | -6.5 | -13.5 (N) | 48.5 | -9.5 (U) | 1 | 22 | 371 | 252 | 44.4 | 33.3 |
| 2 | | Bills | 9/8/2022 | 1-0 | BUF | -131 | @ |  LAR | +110 | W 31-10 | -2.5 | +18.5 (Y) | 52 | -11 (U) | 4 | 23 | 413 | 243 | 90.0 | |
| 3 | | Bills | 9/11/2023 | 0-1 | BUF | -137 | @ |  NYJ | +116 | L 16-22 | -2.5 | -8.5 (N) | 44.5 | -6.5 (U) | 1 | 19 | 314 | 289 | 38.5 | |
| 4 | | Bills | 9/8/2024 | 0-1 | BUF | -308 | vs |  ARI | +246 | W 34-28 | -6.5 | -0.5 (N) | 45.5 | +16.5 (O) | 4 | 23 | 352 | 270 | 33.3 | 100.0 |
| 5 | | Bills | 9/7/2025 | 1-0 | BUF | +102 | vs |  BAL | -122 | W 41-40 | +1.5 | +2.5 (Y) | 52.5 | +28.5 (O) | 5 | 29 | 497 | 432 | 46.7 | 100.0 |
| Average | 8.0 | 3.0 | 23.2 | 389.4 | 297.2 | 49.2 | 22.2 | |||||||||||||
| Total | 2-3 | 15 | 116 | 1,947 | 1,486 | 49.2 | 66.7 |
StatMuse has team, game-level data for spread records going back to the 1979 season.
More Bills Stats
Team Rankings
PPG
28.9
5th
OPP PPG
22.5
14th
RUSH YDS/G
157.8
1st
PASS YDS/G
241.3
12th
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