The 2022 running backs for the Bills included Isaiah Bowser, James Cook III, Reggie Gilliam, Duke Johnson and Taiwan Jones.
| NO. | NAME | POS | HEIGHT | WEIGHT | DOB | AGE | COLLEGE | ||
|---|---|---|---|---|---|---|---|---|---|
| 1 | 0 |  | I. Bowser | RB | |||||
| 2 | 28 |  | J. Cook III | RB | 5'11" | 190 | 9/25/1999 | 23 | Georgia |
| 3 | 41 | | R. Gilliam | RB | 6'1" | 255 | 8/20/1997 | Toledo | |
| 4 | 22 |  | D. Johnson | RB | 5'9" | 210 | 9/23/1993 | 29 | Miami (FL) |
| 5 | 25 | | T. Jones | RB | 6'0" | 195 | 7/26/1988 | 34 | Eastern Washington |
| 6 | 0 | | N. Miller-Hines | RB | 5'9" | 196 | 11/12/1996 | 26 | North Carolina State |
| 7 | 0 | | J. Mims | RB | 6/16/1999 | Fresno State | |||
| 8 | 20 |  | Z. Moss | RB | 5'10" | 215 | 12/15/1997 | 25 | Utah |
| 9 | 26 |  | D. Singletary | RB | 5'7" | 203 | 9/3/1997 | 25 | Florida Atlantic |
More Bills Stats
Team Leaders 
PASS
3,668
Allen
RUSH
1,621
Cook
REC
719
Shakir
Team Rankings
PPG
28.3
4th
OPP PPG
21.5
12th
RUSH YDS/G
159.6
1st
PASS YDS/G
234.2
13th
NFL 2025 Leaders
NFL 2025 Rankings
NFL Fantasy 2025
NFL 2025 Betting
NFL 2025 Standings
| AFC East | W | L | T | PCT |
|---|---|---|---|---|
 Patriots - y | 14 | 3 | 0 | .824 |
 Bills - w | 12 | 5 | 0 | .706 |
 Dolphins - e | 7 | 10 | 0 | .412 |
 Jets - e | 3 | 14 | 0 | .176 |
| AFC North | W | L | T | PCT |
 Steelers - y | 10 | 7 | 0 | .588 |
 Ravens - e | 8 | 9 | 0 | .471 |
 Bengals - e | 6 | 11 | 0 | .353 |
 Browns - e | 5 | 12 | 0 | .294 |
| AFC South | W | L | T | PCT |
 Jaguars - y | 13 | 4 | 0 | .765 |
 Texans - w | 12 | 5 | 0 | .706 |
 Colts - e | 8 | 9 | 0 | .471 |
 Titans - e | 3 | 14 | 0 | .176 |
| AFC West | W | L | T | PCT |
 Broncos - z* | 14 | 3 | 0 | .824 |
 Chargers - w | 11 | 6 | 0 | .647 |
 Chiefs - e | 6 | 11 | 0 | .353 |
 Raiders - e | 3 | 14 | 0 | .176 |
| NFC East | W | L | T | PCT |
|---|---|---|---|---|
 Eagles - y | 11 | 6 | 0 | .647 |
 Cowboys - e | 7 | 9 | 1 | .441 |
 Commanders - e | 5 | 12 | 0 | .294 |
 Giants - e | 4 | 13 | 0 | .235 |
| NFC North | W | L | T | PCT |
 Bears - y | 11 | 6 | 0 | .647 |
 Packers - w | 9 | 7 | 1 | .559 |
 Vikings - e | 9 | 8 | 0 | .529 |
 Lions - e | 9 | 8 | 0 | .529 |
| NFC South | W | L | T | PCT |
 Panthers - y | 8 | 9 | 0 | .471 |
 Buccaneers - e | 8 | 9 | 0 | .471 |
 Falcons - e | 8 | 9 | 0 | .471 |
 Saints - e | 6 | 11 | 0 | .353 |
| NFC West | W | L | T | PCT |
 Seahawks - z* | 14 | 3 | 0 | .824 |
 Rams - w | 12 | 5 | 0 | .706 |
 49ers - w | 12 | 5 | 0 | .706 |
 Cardinals - e | 3 | 14 | 0 | .176 |
