The Arizona Cardinals are 26-32-2 against the spread against the 49ers all-time.

	TEAM	DATE	ATS	TM			OPP		RESULT	SPREAD	ATS DIFF	O/U	O/U DIFF	TD	1DWN	OFF	OPP OFF	3DWN%	4DWN%
1	Cardinals	12/2/1979	0-1	STL		vs	SF		W 13-10	-6	-3 (N)	43	-20 (U)	2	16	286	290
2	Cardinals	9/14/1980	0-0-1	STL		@	SF		L 21-24	+3	0 (P)	42	+3 (O)	3	21	342	392
3	Cardinals	11/21/1982	0-1	STL		vs	SF		L 20-31	+4	-7 (N)	36	+15 (O)	2	15	254	448
4	Cardinals	9/18/1983	0-1	STL		vs	SF		L 27-42	+3.5	-11.5 (N)	45.5	+23.5 (O)	3	22	385	527
5	Cardinals	11/9/1986	0-1	STL		@	SF		L 17-43	+11	-15 (N)	40.5	+19.5 (O)	2	22	364	460
6	Cardinals	10/18/1987		STL		@	SF		L 28-34					4	18	324	448
7	Cardinals	11/6/1988	1-0	PHX		vs	SF		W 24-23	+3.5	+4.5 (Y)	45	+2 (O)	3	21	355	357
8	Cardinals	11/17/1991	1-0	PHX		@	SF		L 10-14	+11.5	+7.5 (Y)	32	-8 (U)	1	13	176	257	20.0	0.0
9	Cardinals	11/1/1992	1-0	PHX		vs	SF		W 24-14	+13	+23 (Y)	43.5	-5.5 (U)	3	21	342	330	68.8
10	Cardinals	10/24/1993	0-1	PHX		@	SF		L 14-28	+11.5	-2.5 (N)	43	-1 (U)	2	25	429	428	58.8	66.7
11	Cardinals	9/27/1999	0-1	ARI		vs	SF		L 10-24	+2.5	-11.5 (N)	46	-12 (U)	1	20	250	322	30.8	100.0
12	Cardinals	10/1/2000	0-1	ARI		@	SF		L 20-27	+3.5	-3.5 (N)	47	0 (P)	2	16	365	345	23.1	66.7
13	Cardinals	10/27/2002	0-1	ARI		@	SF		L 28-38	+8	-2 (N)	40.5	+25.5 (O)	4	23	420	357	75.0	100.0
14	Cardinals	12/21/2002	1-0	ARI		vs	SF		L 14-17	+3.5	+0.5 (Y)	41	-10 (U)	2	14	184	358	53.8
15	Cardinals	10/26/2003	1-0	ARI		vs	SF		W 16-13	+7	+10 (Y)	41	-12 (U)	1	18	314	255	40.0
16	Cardinals	12/7/2003	0-1	ARI		@	SF		L 14-50	+10	-26 (N)	41	+23 (O)	2	18	210	496	21.4	66.7
17	Cardinals	10/10/2004	0-1	ARI		@	SF		L 28-31	+1	-2 (N)	36.5	+22.5 (O)	4	19	320	448	35.7	100.0
18	Cardinals	12/12/2004	0-1	ARI		vs	SF		L 28-31	-7	-10 (N)	36	+23 (O)	3	25	374	352	43.8
19	Cardinals	10/2/2005	1-0	ARI		vs	SF		W 31-14	-2.5	+14.5 (Y)	43.5	+1.5 (O)	2	24	463	168	42.1
20	Cardinals	12/4/2005	1-0	ARI		@	SF		W 17-10	-3	+4 (Y)	44.5	-17.5 (U)	1	18	404	220	31.3	0.0
21	Cardinals	9/10/2006	0-1	ARI	-550	vs	SF	+400	W 34-27	-8	-1 (N)	43	+18 (O)	4	23	367	393	50.0
22	Cardinals	12/24/2006	1-0	ARI	+165	@	SF	-185	W 26-20	+4	+10 (Y)	45	+1 (O)	2	21	372	223	50.0	100.0
23	Cardinals	9/10/2007	0-0-1	ARI	+170	@	SF	-195	L 17-20	+3	0 (P)	45	-8 (U)	2	20	261	194	40.0
24	Cardinals	11/25/2007	0-1	ARI	-625	vs	SF	+450	L 31-37	-10.5	-16.5 (N)	37.5	+30.5 (O)	4	25	552	374	28.6	100.0
25	Cardinals	9/7/2008	1-0	ARI	-135	@	SF	+115	W 23-13	-2.5	+7.5 (Y)	41.5	-5.5 (U)	2	18	285	291	31.3	66.7
	Average		0.7											2.3	19.6	338.3	349.7
	Total		26-32-2											143	1,197	20,639	21,333

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StatMuse has team, game-level data for spread records going back to the 1979 season.

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More Cardinals Stats

Team Leaders

PASS

1,110

Brissett

RUSH

245

Love

REC

308

McBride

Team Rankings

PPG

21.6

22nd

OPP PPG

32.4

32nd

RUSH YDS/G

91.6

23rd

PASS YDS/G

223.4

19th

2026 Division Standings

TEAM	W	L	PCT
49ers	5	0	1.000
Seahawks	3	2	.600
Rams	2	2	.500
Cardinals	1	4	.200

Schedule

DATE	MATCHUP			TIME (ET)
Sun 10/18	ARI	@	LAR	4:05 PM
Sun 10/25	DEN	@	ARI	4:05 PM
Sun 11/1	ARI	@	DAL	1:00 PM
Sun 11/8	ARI	@	SEA	4:25 PM
Sun 11/15	LAR	@	ARI	4:05 PM

Last Game

Lions

3 - 2

Final

Cardinals

1 - 4

Sun 11 Oct 2026

NFL 2026 Leaders

Pass Yards Leaders

1,485

Goff

1,408

Love

1,402

Stroud

Rush Yards Leaders

537

Walker

504

Gibbs

494

Robinson

Rec Yards Leaders

583

Smith-Njigba

537

Olave

507

Lamb

Pass TD Leaders

13

Purdy

12

Goff

12

Cousins

Rush TD Leaders

7

Gibbs

7

Allen

7

Henry

Rec TD Leaders

7

Smith-Njigba

6

Watson

5

St. Brown

QB Rating Leaders

119.6

Jackson

119.3

Purdy

111.3

Goff

Sack Leaders

7.5

Anderson

6.0

Rousseau

5.5

Turner

NFL 2026 Rankings

PPG Rankings

32.8

31.8

30.8

30.3

29.5

29.0

Opp PPG Rankings

12.8

14.0

18.6

18.8

19.2

Total Yards Rankings

417.0

412.0

405.8

395.0

393.8

392.4

Rush Yards Rankings

181.0

173.2

162.3

153.5

139.6

139.0

Pass Yards Rankings

317.0

300.5

297.0

281.6

280.4

276.2

Sack Leaders

20.0

18.0

17.0

16.0

NFL Fantasy 2026

Fantasy RB Rankings

126.7

Gibbs

98.1

Walker

91.4

Robinson

Fantasy WR Rankings

102.5

Smith-Njigba

83.4

Watson

76.1

Lamb

Fantasy TE Rankings

52.4

Likely

50.8

Kittle

49.6

LaPorta

Fantasy K Rankings

75

Shrader

68

Reichard

54

McPherson

NFL 2026 Betting

Best Record ATS

4-1

3-1

3-1-1

Worst Record ATS

0-4-1

1-4

1-3

1-3-1

NFL 2026 Standings

NFC East	W	L	T	PCT
Giants	3	1	1	.700
Eagles	2	3	0	.400
Cowboys	2	3	0	.400
Commanders	1	3	1	.300
NFC North	W	L	T	PCT
Vikings	5	0	0	1.000
Packers	3	2	0	.600
Lions	3	2	0	.600
Bears	3	2	0	.600
NFC South	W	L	T	PCT
Panthers	2	2	0	.500
Falcons	2	2	0	.500
Buccaneers	1	4	0	.200
Saints	1	4	0	.200
NFC West	W	L	T	PCT
49ers	5	0	0	1.000
Seahawks	3	2	0	.600
Rams	2	2	0	.500
Cardinals	1	4	0	.200

AFC East	W	L	T	PCT
Bills	3	1	0	.750
Patriots	3	2	0	.600
Jets	2	3	0	.400
Dolphins	0	5	0	.000
AFC North	W	L	T	PCT
Ravens	3	1	0	.750
Browns	3	2	0	.600
Steelers	3	2	0	.600
Bengals	3	2	0	.600
AFC South	W	L	T	PCT
Jaguars	4	1	0	.800
Colts	2	3	0	.400
Texans	1	4	0	.200
Titans	0	5	0	.000
AFC West	W	L	T	PCT
Chiefs	4	0	0	1.000
Broncos	3	2	0	.600
Raiders	3	2	0	.600
Chargers	0	5	0	.000